Tags

Type your tag names separated by a space and hit enter

OxPL/apoB, lipoprotein(a) and OxLDL biomarkers and cardiovascular disease in chronic hemodialysis patients.
J Nephrol 2011 Sep-Oct; 24(5):581-8JN

Abstract

INTRODUCTION

The aim of this study was to assess the correlation between oxidized phospholipids on apolipoprotein B-100 particles (OxPL/ApoB), lipoprotein(a) and low-density lipoprotein (LDL)-producing oxidized phospholipid (OxLDL) biomarkers and cardiovascular disease (CVD) in chronic hemodialysis (HD) patients.

METHODS

In 52 HD patients, we measured OxPL/apoB by antibody E06, IgG/IgM autoantibody titers to copper-oxidized LDL (Cu-OxLDL) and malondialdehyde (MDA)-LDL, IgG/IgM apolipoprotein B-100-immune complexes (IC/apoB), C-reactive protein (CRP) and lipoprotein(a) (Lp(a)). In all patients, the presence of CVD was assessed.

RESULTS

OxPL/ApoB, IC IgG/IgM, MDA-LDL Ig G/IgM, Cu-OxLDL IgG/IgM and Lp(a) levels were similar in patients with and without CVD. At multiple logistic regression analysis, the association between age and CVD was independent (OR=1.078; 95% confidence interval, 1.005-1.157; p=0.03).

CONCLUSION

In HD patients, OxPL/apoB, lipoprotein(a) and OxLDL biomarkers are not associated with CVD.

Authors+Show Affiliations

Hemodialysis Service, Istituto di Clinica Chirurgica, Università Cattolica del Sacro Cuore, Largo A. Gemelli 8, Rome, Italy. maubosso@tin.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21404224

Citation

Bossola, Maurizio, et al. "OxPL/apoB, Lipoprotein(a) and OxLDL Biomarkers and Cardiovascular Disease in Chronic Hemodialysis Patients." Journal of Nephrology, vol. 24, no. 5, 2011, pp. 581-8.
Bossola M, Tazza L, Luciani G, et al. OxPL/apoB, lipoprotein(a) and OxLDL biomarkers and cardiovascular disease in chronic hemodialysis patients. J Nephrol. 2011;24(5):581-8.
Bossola, M., Tazza, L., Luciani, G., Tortorelli, A., & Tsimikas, S. (2011). OxPL/apoB, lipoprotein(a) and OxLDL biomarkers and cardiovascular disease in chronic hemodialysis patients. Journal of Nephrology, 24(5), pp. 581-8. doi:10.5301/JN.2011.6442.
Bossola M, et al. OxPL/apoB, Lipoprotein(a) and OxLDL Biomarkers and Cardiovascular Disease in Chronic Hemodialysis Patients. J Nephrol. 2011;24(5):581-8. PubMed PMID: 21404224.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - OxPL/apoB, lipoprotein(a) and OxLDL biomarkers and cardiovascular disease in chronic hemodialysis patients. AU - Bossola,Maurizio, AU - Tazza,Luigi, AU - Luciani,Giovanna, AU - Tortorelli,Antonio, AU - Tsimikas,Sotirios, PY - 2010/08/25/accepted PY - 2011/3/16/entrez PY - 2011/3/16/pubmed PY - 2012/1/12/medline SP - 581 EP - 8 JF - Journal of nephrology JO - J. Nephrol. VL - 24 IS - 5 N2 - INTRODUCTION: The aim of this study was to assess the correlation between oxidized phospholipids on apolipoprotein B-100 particles (OxPL/ApoB), lipoprotein(a) and low-density lipoprotein (LDL)-producing oxidized phospholipid (OxLDL) biomarkers and cardiovascular disease (CVD) in chronic hemodialysis (HD) patients. METHODS: In 52 HD patients, we measured OxPL/apoB by antibody E06, IgG/IgM autoantibody titers to copper-oxidized LDL (Cu-OxLDL) and malondialdehyde (MDA)-LDL, IgG/IgM apolipoprotein B-100-immune complexes (IC/apoB), C-reactive protein (CRP) and lipoprotein(a) (Lp(a)). In all patients, the presence of CVD was assessed. RESULTS: OxPL/ApoB, IC IgG/IgM, MDA-LDL Ig G/IgM, Cu-OxLDL IgG/IgM and Lp(a) levels were similar in patients with and without CVD. At multiple logistic regression analysis, the association between age and CVD was independent (OR=1.078; 95% confidence interval, 1.005-1.157; p=0.03). CONCLUSION: In HD patients, OxPL/apoB, lipoprotein(a) and OxLDL biomarkers are not associated with CVD. SN - 1724-6059 UR - https://www.unboundmedicine.com/medline/citation/21404224/OxPL/apoB_lipoprotein_a__and_OxLDL_biomarkers_and_cardiovascular_disease_in_chronic_hemodialysis_patients_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=21404224.ui DB - PRIME DP - Unbound Medicine ER -