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Microbial transformation of diosgenin by filamentous fungus Cunninghamella echinulata.
J Asian Nat Prod Res. 2011 Mar; 13(3):270-5.JA

Abstract

Microbial transformation of diosgenin (1) by suspended-cell cultures of the filamentous fungus Cunninghamella echinulata CGMCC 3.2000 was investigated. Incubation of the substrate diosgenin (1) with this fungus led to the isolation of three products: two known compounds, (25R)-spirost-5-en-3β,7β,12β-triol and (25R)-spirost-5-en-3β,7β,11α-triol, and a new compound (25R)-spirost-5-en-3β,7α,11α-triol. The structural elucidations of the three compounds were achieved mainly by the MS, 1D and 2D NMR spectroscopic methods and comparison with known compounds. C. echinulata CGMCC 3.2000 has not been used before in the biotransformation of diosgenin.

Authors+Show Affiliations

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21409691

Citation

Xiao, Xiao, et al. "Microbial Transformation of Diosgenin By Filamentous Fungus Cunninghamella Echinulata." Journal of Asian Natural Products Research, vol. 13, no. 3, 2011, pp. 270-5.
Xiao X, Liu XK, Fu SB, et al. Microbial transformation of diosgenin by filamentous fungus Cunninghamella echinulata. J Asian Nat Prod Res. 2011;13(3):270-5.
Xiao, X., Liu, X. K., Fu, S. B., & Sun, D. A. (2011). Microbial transformation of diosgenin by filamentous fungus Cunninghamella echinulata. Journal of Asian Natural Products Research, 13(3), 270-5. https://doi.org/10.1080/10286020.2010.551117
Xiao X, et al. Microbial Transformation of Diosgenin By Filamentous Fungus Cunninghamella Echinulata. J Asian Nat Prod Res. 2011;13(3):270-5. PubMed PMID: 21409691.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microbial transformation of diosgenin by filamentous fungus Cunninghamella echinulata. AU - Xiao,Xiao, AU - Liu,Xi-Kui, AU - Fu,Shao-Bin, AU - Sun,Di-An, PY - 2011/3/17/entrez PY - 2011/3/17/pubmed PY - 2011/5/19/medline SP - 270 EP - 5 JF - Journal of Asian natural products research JO - J Asian Nat Prod Res VL - 13 IS - 3 N2 - Microbial transformation of diosgenin (1) by suspended-cell cultures of the filamentous fungus Cunninghamella echinulata CGMCC 3.2000 was investigated. Incubation of the substrate diosgenin (1) with this fungus led to the isolation of three products: two known compounds, (25R)-spirost-5-en-3β,7β,12β-triol and (25R)-spirost-5-en-3β,7β,11α-triol, and a new compound (25R)-spirost-5-en-3β,7α,11α-triol. The structural elucidations of the three compounds were achieved mainly by the MS, 1D and 2D NMR spectroscopic methods and comparison with known compounds. C. echinulata CGMCC 3.2000 has not been used before in the biotransformation of diosgenin. SN - 1477-2213 UR - https://www.unboundmedicine.com/medline/citation/21409691/Microbial_transformation_of_diosgenin_by_filamentous_fungus_Cunninghamella_echinulata_ L2 - http://www.tandfonline.com/doi/full/10.1080/10286020.2010.551117 DB - PRIME DP - Unbound Medicine ER -