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Effect of conjugated estrogen versus conjugated estrogen associated with medroxyprogesterone acetate in postmenopausal women on internal carotid artery pulsatility index: a randomized pilot study.
J Obstet Gynaecol Res. 2011 Jul; 37(7):815-8.JO

Abstract

AIM

To compare the effect of conjugated estrogen (CEE) versus conjugated estrogen and medroxyprogesterone acetate (MPA) therapy on internal carotid artery pulsatility index (PI) in postmenopausal women.

MATERIAL & METHODS

In the prospective, randomized, single-blinded comparative study, postmenopausal women meeting the inclusion criteria were randomized into one of two groups: CEE group (CEE 0.625 mg/day), or CEE + MPA group (CEE 0.625 mg/day plus MPA 2.5 mg/day). Patients were submitted to blood tests (total cholesterol, high-density lipoprotein cholesterol, triglycerides and total glucose) and to color Doppler ultrasound of the internal carotid artery to assess PI at the beginning of the study. Ultrasound was repeated after 16 weeks of treatment. Statistical analysis was performed using Student's t-test or two-way analysis of variance for repeated measures. Data were considered to be significant at P < 0.05.

RESULTS

Seventy-five postmenopausal women (age 53.3 ± 5.5 years) were included in the study. There was a statistically significant reduction in PI in both groups after 16 weeks of hormonal treatment. However, there was no difference between the two groups (group 1: 0.8960 to 0.8450; group 2: 0.9048 to 0.8426).

CONCLUSION

The use of CEE and CEE associated with MPA during 16 weeks led to an improvement in internal carotid flow as measured by PI, with no difference between the treatments.

Authors+Show Affiliations

Postgraduate Program in Medical Sciences, Department of Gynecology and Obstetrics, Clinical Hospital of Porto Alegre, Porto Alegre, RS, Brazil. mceleste@ufrgs.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

21410828

Citation

Wender, Maria C O., et al. "Effect of Conjugated Estrogen Versus Conjugated Estrogen Associated With Medroxyprogesterone Acetate in Postmenopausal Women On Internal Carotid Artery Pulsatility Index: a Randomized Pilot Study." The Journal of Obstetrics and Gynaecology Research, vol. 37, no. 7, 2011, pp. 815-8.
Wender MC, Vigo F, Oliveira PP, et al. Effect of conjugated estrogen versus conjugated estrogen associated with medroxyprogesterone acetate in postmenopausal women on internal carotid artery pulsatility index: a randomized pilot study. J Obstet Gynaecol Res. 2011;37(7):815-8.
Wender, M. C., Vigo, F., Oliveira, P. P., Bittellbrun, F., Furtado, A. P., Schvartzman, L., Capp, E., & de Freitas, F. M. (2011). Effect of conjugated estrogen versus conjugated estrogen associated with medroxyprogesterone acetate in postmenopausal women on internal carotid artery pulsatility index: a randomized pilot study. The Journal of Obstetrics and Gynaecology Research, 37(7), 815-8. https://doi.org/10.1111/j.1447-0756.2010.01441.x
Wender MC, et al. Effect of Conjugated Estrogen Versus Conjugated Estrogen Associated With Medroxyprogesterone Acetate in Postmenopausal Women On Internal Carotid Artery Pulsatility Index: a Randomized Pilot Study. J Obstet Gynaecol Res. 2011;37(7):815-8. PubMed PMID: 21410828.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of conjugated estrogen versus conjugated estrogen associated with medroxyprogesterone acetate in postmenopausal women on internal carotid artery pulsatility index: a randomized pilot study. AU - Wender,Maria C O, AU - Vigo,Francieli, AU - Oliveira,Patricia P, AU - Bittellbrun,Fernando, AU - Furtado,Alvaro P A, AU - Schvartzman,Luiza, AU - Capp,Edison, AU - de Freitas,Fernando Monteiro, Y1 - 2011/03/16/ PY - 2011/3/18/entrez PY - 2011/3/18/pubmed PY - 2012/1/21/medline SP - 815 EP - 8 JF - The journal of obstetrics and gynaecology research JO - J Obstet Gynaecol Res VL - 37 IS - 7 N2 - AIM: To compare the effect of conjugated estrogen (CEE) versus conjugated estrogen and medroxyprogesterone acetate (MPA) therapy on internal carotid artery pulsatility index (PI) in postmenopausal women. MATERIAL & METHODS: In the prospective, randomized, single-blinded comparative study, postmenopausal women meeting the inclusion criteria were randomized into one of two groups: CEE group (CEE 0.625 mg/day), or CEE + MPA group (CEE 0.625 mg/day plus MPA 2.5 mg/day). Patients were submitted to blood tests (total cholesterol, high-density lipoprotein cholesterol, triglycerides and total glucose) and to color Doppler ultrasound of the internal carotid artery to assess PI at the beginning of the study. Ultrasound was repeated after 16 weeks of treatment. Statistical analysis was performed using Student's t-test or two-way analysis of variance for repeated measures. Data were considered to be significant at P < 0.05. RESULTS: Seventy-five postmenopausal women (age 53.3 ± 5.5 years) were included in the study. There was a statistically significant reduction in PI in both groups after 16 weeks of hormonal treatment. However, there was no difference between the two groups (group 1: 0.8960 to 0.8450; group 2: 0.9048 to 0.8426). CONCLUSION: The use of CEE and CEE associated with MPA during 16 weeks led to an improvement in internal carotid flow as measured by PI, with no difference between the treatments. SN - 1447-0756 UR - https://www.unboundmedicine.com/medline/citation/21410828/Effect_of_conjugated_estrogen_versus_conjugated_estrogen_associated_with_medroxyprogesterone_acetate_in_postmenopausal_women_on_internal_carotid_artery_pulsatility_index:_a_randomized_pilot_study_ L2 - https://doi.org/10.1111/j.1447-0756.2010.01441.x DB - PRIME DP - Unbound Medicine ER -