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The effects of oleuropein aglycone, an olive oil compound, in a mouse model of carrageenan-induced pleurisy.
Clin Nutr. 2011 Aug; 30(4):533-40.CN

Abstract

BACKGROUND & AIMS

Several olive oil phenolic compounds, such us oleuropein have attracted considerable attention because of their antioxidant activity, anti-atherosclerotic and anti-inflammatory properties. The aim of this study was to investigate the effects of oleuropein aglycone, a hydrolysis product of oleuropein, in a mouse model of carrageenan-induced pleurisy.

METHODS

Mice were anaesthetized and subjected to a skin incision at the level of the left sixth intercostals space. The underlying muscle was dissected and saline or saline containing 2% λ-carrageenan was injected into the pleural cavity.

RESULTS

Injection of carrageenan elicited an acute inflammatory response characterized by: infiltration of neutrophils in lung tissues (P < 0.01 versus sham. P < 0.01 versus carrageenan) and subsequent lipid peroxidation (P < 0.01 versus sham. P < 0.01 versus carrageenan), increased production of tumor necrosis factor-α and interleukin-1β (P < 0.01 versus sham. P < 0.01 versus carrageenan), increased expression of adhesion molecules, increased synthesis of nitric oxide (P < 0.01 versus sham. P < 0.01 versus carrageenan), nitrotyrosine and poly-ADP-ribose (P < 0.01 versus sham. P < 0.01 versus carrageenan). Administration of oleuropein aglycone 30 min after the challenge with carrageenan, caused a significant reduction of all the parameters of inflammation measured.

CONCLUSIONS

Thus, we propose that olive oil phenolic constituents may be useful in the treatment of various inflammatory diseases.

Authors+Show Affiliations

Department of Clinical and Experimental Medicine, School of Medicine, University of Messina, Via C. Valeria, Gazzi 98100 Messina, Italy. danielaimp@hotmail.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21411195

Citation

Impellizzeri, Daniela, et al. "The Effects of Oleuropein Aglycone, an Olive Oil Compound, in a Mouse Model of Carrageenan-induced Pleurisy." Clinical Nutrition (Edinburgh, Scotland), vol. 30, no. 4, 2011, pp. 533-40.
Impellizzeri D, Esposito E, Mazzon E, et al. The effects of oleuropein aglycone, an olive oil compound, in a mouse model of carrageenan-induced pleurisy. Clin Nutr. 2011;30(4):533-40.
Impellizzeri, D., Esposito, E., Mazzon, E., Paterniti, I., Di Paola, R., Bramanti, P., Morittu, V. M., Procopio, A., Britti, D., & Cuzzocrea, S. (2011). The effects of oleuropein aglycone, an olive oil compound, in a mouse model of carrageenan-induced pleurisy. Clinical Nutrition (Edinburgh, Scotland), 30(4), 533-40. https://doi.org/10.1016/j.clnu.2011.02.004
Impellizzeri D, et al. The Effects of Oleuropein Aglycone, an Olive Oil Compound, in a Mouse Model of Carrageenan-induced Pleurisy. Clin Nutr. 2011;30(4):533-40. PubMed PMID: 21411195.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of oleuropein aglycone, an olive oil compound, in a mouse model of carrageenan-induced pleurisy. AU - Impellizzeri,Daniela, AU - Esposito,Emanuela, AU - Mazzon,Emanuela, AU - Paterniti,Irene, AU - Di Paola,Rosanna, AU - Bramanti,Placido, AU - Morittu,Valeria Maria, AU - Procopio,Antonio, AU - Britti,Domenico, AU - Cuzzocrea,Salvatore, Y1 - 2011/03/15/ PY - 2010/12/20/received PY - 2011/01/27/revised PY - 2011/02/12/accepted PY - 2011/3/18/entrez PY - 2011/3/18/pubmed PY - 2011/12/16/medline SP - 533 EP - 40 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 30 IS - 4 N2 - BACKGROUND & AIMS: Several olive oil phenolic compounds, such us oleuropein have attracted considerable attention because of their antioxidant activity, anti-atherosclerotic and anti-inflammatory properties. The aim of this study was to investigate the effects of oleuropein aglycone, a hydrolysis product of oleuropein, in a mouse model of carrageenan-induced pleurisy. METHODS: Mice were anaesthetized and subjected to a skin incision at the level of the left sixth intercostals space. The underlying muscle was dissected and saline or saline containing 2% λ-carrageenan was injected into the pleural cavity. RESULTS: Injection of carrageenan elicited an acute inflammatory response characterized by: infiltration of neutrophils in lung tissues (P < 0.01 versus sham. P < 0.01 versus carrageenan) and subsequent lipid peroxidation (P < 0.01 versus sham. P < 0.01 versus carrageenan), increased production of tumor necrosis factor-α and interleukin-1β (P < 0.01 versus sham. P < 0.01 versus carrageenan), increased expression of adhesion molecules, increased synthesis of nitric oxide (P < 0.01 versus sham. P < 0.01 versus carrageenan), nitrotyrosine and poly-ADP-ribose (P < 0.01 versus sham. P < 0.01 versus carrageenan). Administration of oleuropein aglycone 30 min after the challenge with carrageenan, caused a significant reduction of all the parameters of inflammation measured. CONCLUSIONS: Thus, we propose that olive oil phenolic constituents may be useful in the treatment of various inflammatory diseases. SN - 1532-1983 UR - https://www.unboundmedicine.com/medline/citation/21411195/The_effects_of_oleuropein_aglycone_an_olive_oil_compound_in_a_mouse_model_of_carrageenan_induced_pleurisy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(11)00036-7 DB - PRIME DP - Unbound Medicine ER -