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Donor cell-derived leukemias/myelodysplastic neoplasms in allogeneic hematopoietic stem cell transplant recipients: a clinicopathologic study of 10 cases and a comprehensive review of the literature.
Am J Clin Pathol. 2011 Apr; 135(4):525-40.AJ

Abstract

We report 10 cases of donor cell leukemia (DCL). All cases except the case of chronic lymphocytic leukemia had anemia, neutropenia, and/or thrombocytopenia when DCL was diagnosed. Eight cases with sex-mismatched hematopoietic stem cell transplant (HCT) showed donor gonosomal complements, suggesting DCL. Clonal cytogenetic abnormalities were detected in 8 cases: 6 were monosomy 7/del(7q). In all 10 cases, engraftment studies confirmed donor cell origin. Retrospective fluorescence in situ hybridization in archived donor cells in 4 cases showed a low level of abnormalities in 2. Of 7 patients with clinical follow-up of 5 months or more, 1 (with acute myeloid leukemia) died of disease; 6 are alive, including 1 with myelodysplastic syndrome with spontaneous remission. Similar to reported cases, we found disproportional sex-mismatched HCTs, suggesting probable underdetection of DCL in sex-matched HCTs. The latency between HCT and DCL ranged from 1 to 193 months (median, 24 months), in keeping with the literature. Analyzing our cases, pooled with reported cases, with survival models showed much shorter latency for malignancy as primary disease, for T-cell large granular lymphocyte leukemia as type of DCL, and for umbilical cord blood as stem cell source.

Authors+Show Affiliations

Dept of Pathology, Duke University Medical Center, Durham, NC, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

21411775

Citation

Wang, Endi, et al. "Donor Cell-derived Leukemias/myelodysplastic Neoplasms in Allogeneic Hematopoietic Stem Cell Transplant Recipients: a Clinicopathologic Study of 10 Cases and a Comprehensive Review of the Literature." American Journal of Clinical Pathology, vol. 135, no. 4, 2011, pp. 525-40.
Wang E, Hutchinson CB, Huang Q, et al. Donor cell-derived leukemias/myelodysplastic neoplasms in allogeneic hematopoietic stem cell transplant recipients: a clinicopathologic study of 10 cases and a comprehensive review of the literature. Am J Clin Pathol. 2011;135(4):525-40.
Wang, E., Hutchinson, C. B., Huang, Q., Lu, C. M., Crow, J., Wang, F. F., Sebastian, S., Rehder, C., Lagoo, A., Horwitz, M., Rizzieri, D., Yu, J., Goodman, B., Datto, M., & Buckley, P. (2011). Donor cell-derived leukemias/myelodysplastic neoplasms in allogeneic hematopoietic stem cell transplant recipients: a clinicopathologic study of 10 cases and a comprehensive review of the literature. American Journal of Clinical Pathology, 135(4), 525-40. https://doi.org/10.1309/AJCPPJUQ9DNR1GHP
Wang E, et al. Donor Cell-derived Leukemias/myelodysplastic Neoplasms in Allogeneic Hematopoietic Stem Cell Transplant Recipients: a Clinicopathologic Study of 10 Cases and a Comprehensive Review of the Literature. Am J Clin Pathol. 2011;135(4):525-40. PubMed PMID: 21411775.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Donor cell-derived leukemias/myelodysplastic neoplasms in allogeneic hematopoietic stem cell transplant recipients: a clinicopathologic study of 10 cases and a comprehensive review of the literature. AU - Wang,Endi, AU - Hutchinson,Charles Blake, AU - Huang,Qin, AU - Lu,Chuanyi Mark, AU - Crow,Jennifer, AU - Wang,Frances F, AU - Sebastian,Siby, AU - Rehder,Catherine, AU - Lagoo,Anand, AU - Horwitz,Mitchell, AU - Rizzieri,David, AU - Yu,Jingwei, AU - Goodman,Barbara, AU - Datto,Michael, AU - Buckley,Patrick, PY - 2011/3/18/entrez PY - 2011/3/18/pubmed PY - 2011/5/13/medline SP - 525 EP - 40 JF - American journal of clinical pathology JO - Am J Clin Pathol VL - 135 IS - 4 N2 - We report 10 cases of donor cell leukemia (DCL). All cases except the case of chronic lymphocytic leukemia had anemia, neutropenia, and/or thrombocytopenia when DCL was diagnosed. Eight cases with sex-mismatched hematopoietic stem cell transplant (HCT) showed donor gonosomal complements, suggesting DCL. Clonal cytogenetic abnormalities were detected in 8 cases: 6 were monosomy 7/del(7q). In all 10 cases, engraftment studies confirmed donor cell origin. Retrospective fluorescence in situ hybridization in archived donor cells in 4 cases showed a low level of abnormalities in 2. Of 7 patients with clinical follow-up of 5 months or more, 1 (with acute myeloid leukemia) died of disease; 6 are alive, including 1 with myelodysplastic syndrome with spontaneous remission. Similar to reported cases, we found disproportional sex-mismatched HCTs, suggesting probable underdetection of DCL in sex-matched HCTs. The latency between HCT and DCL ranged from 1 to 193 months (median, 24 months), in keeping with the literature. Analyzing our cases, pooled with reported cases, with survival models showed much shorter latency for malignancy as primary disease, for T-cell large granular lymphocyte leukemia as type of DCL, and for umbilical cord blood as stem cell source. SN - 1943-7722 UR - https://www.unboundmedicine.com/medline/citation/21411775/Donor_cell_derived_leukemias/myelodysplastic_neoplasms_in_allogeneic_hematopoietic_stem_cell_transplant_recipients:_a_clinicopathologic_study_of_10_cases_and_a_comprehensive_review_of_the_literature_ L2 - https://academic.oup.com/ajcp/article-lookup/doi/10.1309/AJCPPJUQ9DNR1GHP DB - PRIME DP - Unbound Medicine ER -