Type your tag names separated by a space and hit enter

Identification of cannabinoid type 1 receptor in dog hair follicles.

Abstract

In veterinary medicine, there is an increasing interest in the study of the endo-cannabinoid system and the possible use of the cannabinoids for the treatment of several diseases. Cannabinoid receptors (CB) are widely distributed in human and laboratory animal tissues, justifying the involvement of the endo-cannabinoid system in a great number of metabolic ways. Since there are no data regarding cannabinoid receptors in hair follicles of domestic animals, we investigated the presence and localization of CB1 receptor in dog hair follicles. By using a goat anti-CB1 polyclonal antibody, we observed CB1 receptor in the proximal part of both primary and secondary hair follicles. Staining was localized in the inner root sheath cells. We suppose that the endo-cannabinoid system is involved in the molecular mechanisms regulating hair follicle activity in dog. The identification of CB1 receptor at the level of the inner root sheath may help in the understanding of hair follicle biology and the possibility that cannabinoid molecules could be considered as suitable therapeutic tools in dog.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Sezione di Anatomia Veterinaria, Dipartimento di Scienze Biopatologiche ed Igiene delle Produzioni Animali e Alimentari, Perugia, Italy. fmercati@yahoo.it

    , , ,

    Source

    Acta histochemica 114:1 2012 Jan pg 68-71

    MeSH

    Animals
    Dogs
    Female
    Hair Follicle
    Male
    Receptor, Cannabinoid, CB1

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    21414652

    Citation

    * When formatting your citation, note that all book, journal, and database titles should be italicized* Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Identification of cannabinoid type 1 receptor in dog hair follicles. AU - Mercati,Francesca, AU - Dall'Aglio,Cecilia, AU - Pascucci,Luisa, AU - Boiti,Cristiano, AU - Ceccarelli,Piero, Y1 - 2011/03/16/ PY - 2010/12/16/received PY - 2011/01/21/revised PY - 2011/01/23/accepted PY - 2011/3/19/entrez PY - 2011/3/19/pubmed PY - 2012/8/21/medline SP - 68 EP - 71 JF - Acta histochemica JO - Acta Histochem. VL - 114 IS - 1 N2 - In veterinary medicine, there is an increasing interest in the study of the endo-cannabinoid system and the possible use of the cannabinoids for the treatment of several diseases. Cannabinoid receptors (CB) are widely distributed in human and laboratory animal tissues, justifying the involvement of the endo-cannabinoid system in a great number of metabolic ways. Since there are no data regarding cannabinoid receptors in hair follicles of domestic animals, we investigated the presence and localization of CB1 receptor in dog hair follicles. By using a goat anti-CB1 polyclonal antibody, we observed CB1 receptor in the proximal part of both primary and secondary hair follicles. Staining was localized in the inner root sheath cells. We suppose that the endo-cannabinoid system is involved in the molecular mechanisms regulating hair follicle activity in dog. The identification of CB1 receptor at the level of the inner root sheath may help in the understanding of hair follicle biology and the possibility that cannabinoid molecules could be considered as suitable therapeutic tools in dog. SN - 1618-0372 UR - https://www.unboundmedicine.com/medline/citation/21414652/abstract/Identification_of_cannabinoid_type_1_receptor_in_dog_hair_follicles_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0065-1281(11)00033-X DB - PRIME DP - Unbound Medicine ER -