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Dietary supplementation with dried plum prevents ovariectomy-induced bone loss while modulating the immune response in C57BL/6J mice.
J Nutr Biochem. 2012 Jan; 23(1):60-8.JN

Abstract

This study was designed to investigate the effects of dried plum on the changes in bone metabolism and the immune response associated with ovarian hormone deficiency. Adult female C57BL/6J mice were either sham-operated (Sham) and fed AIN-93 diet (control) or ovariectomized (OVX) and fed a control diet with 0%, 5%, 15% or 25% dried plum (w/w), corresponding to control, low- (LDP), medium- (MDP) and high (HDP)-dose dried plum. Four weeks of HDP supplementation prevented the decrease in spine bone mineral density and content induced by OVX. The OVX compromise in trabecular bone of the vertebra and proximal tibia was prevented by the higher doses of dried plum, and in the vertebra these effects resulted in greater (P<.05) bone strength and stiffness. In the bone marrow, OVX suppressed granulocyte and committed monocyte populations and increased the lymphoblast population, but the MDP and HDP restored these myeloid and lymphoid populations to the level of the Sham. Dried plum also suppressed lymphocyte tumor necrosis factor (TNF)-α production ex vivo by splenocytes, in response to concanavalin (Con) A stimulation. These data indicate that dried plum's positive effects on bone structural and biomechanical properties coincide with the restoration of certain bone marrow myeloid and lymphoid populations, and suppressed splenocyte activation occurring with ovarian hormone deficiency.

Authors+Show Affiliations

Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74078, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21414765

Citation

Rendina, Elizabeth, et al. "Dietary Supplementation With Dried Plum Prevents Ovariectomy-induced Bone Loss While Modulating the Immune Response in C57BL/6J Mice." The Journal of Nutritional Biochemistry, vol. 23, no. 1, 2012, pp. 60-8.
Rendina E, Lim YF, Marlow D, et al. Dietary supplementation with dried plum prevents ovariectomy-induced bone loss while modulating the immune response in C57BL/6J mice. J Nutr Biochem. 2012;23(1):60-8.
Rendina, E., Lim, Y. F., Marlow, D., Wang, Y., Clarke, S. L., Kuvibidila, S., Lucas, E. A., & Smith, B. J. (2012). Dietary supplementation with dried plum prevents ovariectomy-induced bone loss while modulating the immune response in C57BL/6J mice. The Journal of Nutritional Biochemistry, 23(1), 60-8. https://doi.org/10.1016/j.jnutbio.2010.10.010
Rendina E, et al. Dietary Supplementation With Dried Plum Prevents Ovariectomy-induced Bone Loss While Modulating the Immune Response in C57BL/6J Mice. J Nutr Biochem. 2012;23(1):60-8. PubMed PMID: 21414765.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary supplementation with dried plum prevents ovariectomy-induced bone loss while modulating the immune response in C57BL/6J mice. AU - Rendina,Elizabeth, AU - Lim,Yin F, AU - Marlow,Denver, AU - Wang,Yan, AU - Clarke,Stephen L, AU - Kuvibidila,Solo, AU - Lucas,Edralin A, AU - Smith,Brenda J, Y1 - 2011/03/16/ PY - 2010/03/12/received PY - 2010/07/13/revised PY - 2010/10/12/accepted PY - 2011/3/19/entrez PY - 2011/3/19/pubmed PY - 2012/6/20/medline SP - 60 EP - 8 JF - The Journal of nutritional biochemistry JO - J. Nutr. Biochem. VL - 23 IS - 1 N2 - This study was designed to investigate the effects of dried plum on the changes in bone metabolism and the immune response associated with ovarian hormone deficiency. Adult female C57BL/6J mice were either sham-operated (Sham) and fed AIN-93 diet (control) or ovariectomized (OVX) and fed a control diet with 0%, 5%, 15% or 25% dried plum (w/w), corresponding to control, low- (LDP), medium- (MDP) and high (HDP)-dose dried plum. Four weeks of HDP supplementation prevented the decrease in spine bone mineral density and content induced by OVX. The OVX compromise in trabecular bone of the vertebra and proximal tibia was prevented by the higher doses of dried plum, and in the vertebra these effects resulted in greater (P<.05) bone strength and stiffness. In the bone marrow, OVX suppressed granulocyte and committed monocyte populations and increased the lymphoblast population, but the MDP and HDP restored these myeloid and lymphoid populations to the level of the Sham. Dried plum also suppressed lymphocyte tumor necrosis factor (TNF)-α production ex vivo by splenocytes, in response to concanavalin (Con) A stimulation. These data indicate that dried plum's positive effects on bone structural and biomechanical properties coincide with the restoration of certain bone marrow myeloid and lymphoid populations, and suppressed splenocyte activation occurring with ovarian hormone deficiency. SN - 1873-4847 UR - https://www.unboundmedicine.com/medline/citation/21414765/Dietary_supplementation_with_dried_plum_prevents_ovariectomy_induced_bone_loss_while_modulating_the_immune_response_in_C57BL/6J_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0955-2863(10)00265-2 DB - PRIME DP - Unbound Medicine ER -