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Intraspinal Ewing's sarcoma/primitive neuroectodermal tumors.
J Clin Neurosci. 2011 May; 18(5):601-6.JC

Abstract

Intraspinal Ewing's sarcoma (ES) and primitive neuroectodermal tumors (PNET) are very rare, and the characteristics and prognoses of the disease remain unclear. We present an illustrative patient with an intradural, extramedullary PNET arising within the cervical spinal canal, with clinical and radiological manifestations of leptomeningeal spread, and review the reports of a further 77 patients with intraspinal ES/PNET. Cox regression analyses showed that tumor location (extradural, intradural) (p=0.002, RR=4.217, 95% confidence interval [CI] 1.668-10.664) and spinal segment location (cervical, thoracic, lumbar, or sacral) (p=0.017, RR=2.040, 95% CI 1.133-3.673) were independent factors in the prognosis of intraspinal ES/PNET. We concluded that a peripheral PNET may originate within the spinal canal and exhibit leptomeningeal spread similar to that seen in central PNET, and that a patient with an intradural ES/PNET high in the spinal canal is more likely to have a poor prognosis.

Authors+Show Affiliations

Department of Neurosurgery, Changzheng Hospital, Neurosurgery Research Institution of Shanghai, 415 Fengyang Street, Huangpu District, Shanghai 200003, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

21414790

Citation

Yan, Yong, et al. "Intraspinal Ewing's Sarcoma/primitive Neuroectodermal Tumors." Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, vol. 18, no. 5, 2011, pp. 601-6.
Yan Y, Xu T, Chen J, et al. Intraspinal Ewing's sarcoma/primitive neuroectodermal tumors. J Clin Neurosci. 2011;18(5):601-6.
Yan, Y., Xu, T., Chen, J., Hu, G., & Lu, Y. (2011). Intraspinal Ewing's sarcoma/primitive neuroectodermal tumors. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, 18(5), 601-6. https://doi.org/10.1016/j.jocn.2010.09.012
Yan Y, et al. Intraspinal Ewing's Sarcoma/primitive Neuroectodermal Tumors. J Clin Neurosci. 2011;18(5):601-6. PubMed PMID: 21414790.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intraspinal Ewing's sarcoma/primitive neuroectodermal tumors. AU - Yan,Yong, AU - Xu,Tao, AU - Chen,Juxiang, AU - Hu,Guohan, AU - Lu,Yicheng, PY - 2010/08/13/received PY - 2010/09/15/revised PY - 2010/09/22/accepted PY - 2011/3/19/entrez PY - 2011/3/19/pubmed PY - 2011/8/9/medline SP - 601 EP - 6 JF - Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia JO - J Clin Neurosci VL - 18 IS - 5 N2 - Intraspinal Ewing's sarcoma (ES) and primitive neuroectodermal tumors (PNET) are very rare, and the characteristics and prognoses of the disease remain unclear. We present an illustrative patient with an intradural, extramedullary PNET arising within the cervical spinal canal, with clinical and radiological manifestations of leptomeningeal spread, and review the reports of a further 77 patients with intraspinal ES/PNET. Cox regression analyses showed that tumor location (extradural, intradural) (p=0.002, RR=4.217, 95% confidence interval [CI] 1.668-10.664) and spinal segment location (cervical, thoracic, lumbar, or sacral) (p=0.017, RR=2.040, 95% CI 1.133-3.673) were independent factors in the prognosis of intraspinal ES/PNET. We concluded that a peripheral PNET may originate within the spinal canal and exhibit leptomeningeal spread similar to that seen in central PNET, and that a patient with an intradural ES/PNET high in the spinal canal is more likely to have a poor prognosis. SN - 1532-2653 UR - https://www.unboundmedicine.com/medline/citation/21414790/Intraspinal_Ewing's_sarcoma/primitive_neuroectodermal_tumors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0967-5868(10)00780-0 DB - PRIME DP - Unbound Medicine ER -