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Hemodynamic alterations in cirrhosis and portal hypertension.
Korean J Hepatol. 2010 Dec; 16(4):347-52.KJ

Abstract

Portal hypertension (PHT) is associated with hemodynamic changes in intrahepatic, systemic, and portosystemic collateral circulation. Increased intrahepatic resistance and hyperdynamic circulatory alterations with expansion of collateral circulation play a central role in the pathogenesis of PHT. PHT is also characterized by changes in vascular structure, termed vascular remodeling, which is an adaptive response of the vessel wall that occurs in response to chronic changes in the environment such as shear stress. Angiogenesis, the formation of new blood vessels, also occurs with PHT related in particular to the expansion of portosystemic collateral circulation. The complementary processes of vasoreactivity, vascular remodeling, and angiogenesis represent important targets for the treatment of portal hypertension. Systemic and splanchnic vasodilatation can induce hyperdynamic circulation which is related with multi-organ failure such as hepatorenal syndrome and cirrhotic cadiomyopathy.

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Authors+Show Affiliations

Kim MY
Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
Baik SK
No affiliation info available
Lee SS
No affiliation info available

MeSH

Collateral CirculationEndothelial CellsHemodynamicsHepatic Stellate CellsHypertension, PortalLiver CirculationLiver CirrhosisSplanchnic Circulation

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

21415576

Citation

Kim, Moon Young, et al. "Hemodynamic Alterations in Cirrhosis and Portal Hypertension." The Korean Journal of Hepatology, vol. 16, no. 4, 2010, pp. 347-52.
Kim MY, Baik SK, Lee SS. Hemodynamic alterations in cirrhosis and portal hypertension. Korean J Hepatol. 2010;16(4):347-52.
Kim, M. Y., Baik, S. K., & Lee, S. S. (2010). Hemodynamic alterations in cirrhosis and portal hypertension. The Korean Journal of Hepatology, 16(4), 347-52. https://doi.org/10.3350/kjhep.2010.16.4.347
Kim MY, Baik SK, Lee SS. Hemodynamic Alterations in Cirrhosis and Portal Hypertension. Korean J Hepatol. 2010;16(4):347-52. PubMed PMID: 21415576.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hemodynamic alterations in cirrhosis and portal hypertension. AU - Kim,Moon Young, AU - Baik,Soon Koo, AU - Lee,Samuel S, PY - 2011/3/19/entrez PY - 2011/3/19/pubmed PY - 2011/6/29/medline SP - 347 EP - 52 JF - The Korean journal of hepatology JO - Korean J Hepatol VL - 16 IS - 4 N2 - Portal hypertension (PHT) is associated with hemodynamic changes in intrahepatic, systemic, and portosystemic collateral circulation. Increased intrahepatic resistance and hyperdynamic circulatory alterations with expansion of collateral circulation play a central role in the pathogenesis of PHT. PHT is also characterized by changes in vascular structure, termed vascular remodeling, which is an adaptive response of the vessel wall that occurs in response to chronic changes in the environment such as shear stress. Angiogenesis, the formation of new blood vessels, also occurs with PHT related in particular to the expansion of portosystemic collateral circulation. The complementary processes of vasoreactivity, vascular remodeling, and angiogenesis represent important targets for the treatment of portal hypertension. Systemic and splanchnic vasodilatation can induce hyperdynamic circulation which is related with multi-organ failure such as hepatorenal syndrome and cirrhotic cadiomyopathy. SN - 1738-222X UR - https://www.unboundmedicine.com/medline/citation/21415576/Hemodynamic_alterations_in_cirrhosis_and_portal_hypertension_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21415576/ DB - PRIME DP - Unbound Medicine ER -