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A novel approach reveals that zinc oxide nanoparticles are bioavailable and toxic after dietary exposures.
Nanotoxicology. 2011 Mar; 5(1):79-90.N

Abstract

If engineered nanomaterials are released into the environment, some are likely to end up associated with the food of animals due to aggregation and sorption processes. However, few studies have considered dietary exposure of nanomaterials. Here we show that zinc (Zn) from isotopically modified (67)ZnO particles is efficiently assimilated by freshwater snails when ingested with food. The (67)Zn from nano-sized (67)ZnO appears as bioavailable as (67)Zn internalized by diatoms. Apparent agglomeration of the zinc oxide (ZnO) particles did not reduce bioavailability, nor preclude toxicity. In the diet, ZnO nanoparticles damage digestion: snails ate less, defecated less and inefficiently processed the ingested food when exposed to high concentrations of ZnO. It was not clear whether the toxicity was due to the high Zn dose achieved with nanoparticles or to the ZnO nanoparticles themselves. Further study of exposure from nanoparticles in food would greatly benefit assessment of ecological and human health risks.

Authors+Show Affiliations

U.S. Geological Survey, Menlo Park, California 94025, USA. mcroteau@usgs.govNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

21417690

Citation

Croteau, Marie-Noële, et al. "A Novel Approach Reveals That Zinc Oxide Nanoparticles Are Bioavailable and Toxic After Dietary Exposures." Nanotoxicology, vol. 5, no. 1, 2011, pp. 79-90.
Croteau MN, Dybowska AD, Luoma SN, et al. A novel approach reveals that zinc oxide nanoparticles are bioavailable and toxic after dietary exposures. Nanotoxicology. 2011;5(1):79-90.
Croteau, M. N., Dybowska, A. D., Luoma, S. N., & Valsami-Jones, E. (2011). A novel approach reveals that zinc oxide nanoparticles are bioavailable and toxic after dietary exposures. Nanotoxicology, 5(1), 79-90. https://doi.org/10.3109/17435390.2010.501914
Croteau MN, et al. A Novel Approach Reveals That Zinc Oxide Nanoparticles Are Bioavailable and Toxic After Dietary Exposures. Nanotoxicology. 2011;5(1):79-90. PubMed PMID: 21417690.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A novel approach reveals that zinc oxide nanoparticles are bioavailable and toxic after dietary exposures. AU - Croteau,Marie-Noële, AU - Dybowska,Agnieszka D, AU - Luoma,Samuel N, AU - Valsami-Jones,Eugenia, Y1 - 2010/07/15/ PY - 2011/3/23/entrez PY - 2011/3/23/pubmed PY - 2011/7/6/medline SP - 79 EP - 90 JF - Nanotoxicology JO - Nanotoxicology VL - 5 IS - 1 N2 - If engineered nanomaterials are released into the environment, some are likely to end up associated with the food of animals due to aggregation and sorption processes. However, few studies have considered dietary exposure of nanomaterials. Here we show that zinc (Zn) from isotopically modified (67)ZnO particles is efficiently assimilated by freshwater snails when ingested with food. The (67)Zn from nano-sized (67)ZnO appears as bioavailable as (67)Zn internalized by diatoms. Apparent agglomeration of the zinc oxide (ZnO) particles did not reduce bioavailability, nor preclude toxicity. In the diet, ZnO nanoparticles damage digestion: snails ate less, defecated less and inefficiently processed the ingested food when exposed to high concentrations of ZnO. It was not clear whether the toxicity was due to the high Zn dose achieved with nanoparticles or to the ZnO nanoparticles themselves. Further study of exposure from nanoparticles in food would greatly benefit assessment of ecological and human health risks. SN - 1743-5404 UR - https://www.unboundmedicine.com/medline/citation/21417690/A_novel_approach_reveals_that_zinc_oxide_nanoparticles_are_bioavailable_and_toxic_after_dietary_exposures_ L2 - https://www.tandfonline.com/doi/full/10.3109/17435390.2010.501914 DB - PRIME DP - Unbound Medicine ER -