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Synthesis and in vitro microbiological evaluation of novel diethyl 6,6'-(1,4-phenylene)bis(4-aryl-2-oxo-cyclohex-3-enecarboxylates).
J Enzyme Inhib Med Chem. 2011 Aug; 26(4):498-505.JE

Abstract

Novel bis cyclohexenone ester derivatives 14-19 were synthesized and characterized by their spectral data. In vitro microbiological evaluations were carried out for all the novel compounds 14-19 against clinically isolated bacterial and fungal strains. Compounds 15, 16, 18 against Staphylococcus aureus, 14, 15 against β-Haemolytic streptococcus, 15, 19 against Micrococcus luteus, 17, 18 against Salmonella typhii, 14, 17 against Shigella flexneri, 15 against Escherichia coli, 16 against Pseudomonas aeruginosa, 15, 18, 19 against Klebsiella pneumonia exhibited potent antibacterial activity at an minimum inhibitory concentration (MIC) value of 6.25 μg/ml, whereas compound 16 against Aspergillus flavus, 17 against A. niger, 16, 18 against Mucor indicus, 15, 17-19 against Microsporum gypseum revealed excellent antifungal activity at an MIC value of 6.25 μg/ml.

Authors+Show Affiliations

Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University, Annamalainagar-608 002, Tamil Nadu, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21417963

Citation

Kanagarajan, V, et al. "Synthesis and in Vitro Microbiological Evaluation of Novel Diethyl 6,6'-(1,4-phenylene)bis(4-aryl-2-oxo-cyclohex-3-enecarboxylates)." Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 26, no. 4, 2011, pp. 498-505.
Kanagarajan V, Ezhilarasi MR, Gopalakrishnan M. Synthesis and in vitro microbiological evaluation of novel diethyl 6,6'-(1,4-phenylene)bis(4-aryl-2-oxo-cyclohex-3-enecarboxylates). J Enzyme Inhib Med Chem. 2011;26(4):498-505.
Kanagarajan, V., Ezhilarasi, M. R., & Gopalakrishnan, M. (2011). Synthesis and in vitro microbiological evaluation of novel diethyl 6,6'-(1,4-phenylene)bis(4-aryl-2-oxo-cyclohex-3-enecarboxylates). Journal of Enzyme Inhibition and Medicinal Chemistry, 26(4), 498-505. https://doi.org/10.3109/14756366.2010.530263
Kanagarajan V, Ezhilarasi MR, Gopalakrishnan M. Synthesis and in Vitro Microbiological Evaluation of Novel Diethyl 6,6'-(1,4-phenylene)bis(4-aryl-2-oxo-cyclohex-3-enecarboxylates). J Enzyme Inhib Med Chem. 2011;26(4):498-505. PubMed PMID: 21417963.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis and in vitro microbiological evaluation of novel diethyl 6,6'-(1,4-phenylene)bis(4-aryl-2-oxo-cyclohex-3-enecarboxylates). AU - Kanagarajan,V, AU - Ezhilarasi,M R, AU - Gopalakrishnan,M, Y1 - 2011/03/22/ PY - 2011/3/23/entrez PY - 2011/3/23/pubmed PY - 2011/12/31/medline SP - 498 EP - 505 JF - Journal of enzyme inhibition and medicinal chemistry JO - J Enzyme Inhib Med Chem VL - 26 IS - 4 N2 - Novel bis cyclohexenone ester derivatives 14-19 were synthesized and characterized by their spectral data. In vitro microbiological evaluations were carried out for all the novel compounds 14-19 against clinically isolated bacterial and fungal strains. Compounds 15, 16, 18 against Staphylococcus aureus, 14, 15 against β-Haemolytic streptococcus, 15, 19 against Micrococcus luteus, 17, 18 against Salmonella typhii, 14, 17 against Shigella flexneri, 15 against Escherichia coli, 16 against Pseudomonas aeruginosa, 15, 18, 19 against Klebsiella pneumonia exhibited potent antibacterial activity at an minimum inhibitory concentration (MIC) value of 6.25 μg/ml, whereas compound 16 against Aspergillus flavus, 17 against A. niger, 16, 18 against Mucor indicus, 15, 17-19 against Microsporum gypseum revealed excellent antifungal activity at an MIC value of 6.25 μg/ml. SN - 1475-6374 UR - https://www.unboundmedicine.com/medline/citation/21417963/Synthesis_and_in_vitro_microbiological_evaluation_of_novel_diethyl_66'__14_phenylene_bis_4_aryl_2_oxo_cyclohex_3_enecarboxylates__ L2 - https://www.tandfonline.com/doi/full/10.3109/14756366.2010.530263 DB - PRIME DP - Unbound Medicine ER -