Tags

Type your tag names separated by a space and hit enter

[Systematic review and meta-analysis of randomized controlled trials of Chinese herbal medicine in the treatment of Sjogren's syndrome].
Zhong Xi Yi Jie He Xue Bao. 2011 Mar; 9(3):257-74.ZX

Abstract

BACKGROUND

Chinese herbal medicine (CHM) has been widely used in the treatment of Sjogren's syndrome. However, there remains no systematic review to assess the effectiveness and safety of CHM.

OBJECTIVE

To assess the effectiveness and safety of CHM in the treatment of Sjogren's syndrome.

SEARCH STRATEGY

Literature was searched from PubMed, the Cochrane Library (Issue 3, 2010), the China National Knowledge Infrastructure Database, the Chongqing VIP Chinese Science and Technology Periodical Database, the Chinese Biomedical Literature Database (SinoMed), Wanfang Data and the Traditional Chinese Medical Periodical Literature Database. The time limitation ran from the commencement of each database to October 15, 2010.

INCLUSION CRITERIA

Randomized controlled trials (RCTs) testing CHM alone or in combination with Western medicine (WM) against WM or placebo used alone were included.

DATA EXTRACTION AND ANALYSIS

Two authors collected data independently. The assessment of methodological quality was based on the Cochrane handbook and the data were analyzed by using RevMan 5.0.17 software. Heterogeneity of the included studies was tested and use of statistical model was based on the heterogeneity. The efficacy measure was relative risk (RR) or mean difference with a 95% confidence interval (CI).

RESULTS

A total of 52 RCTs involving 3 886 patients were included. The included trials were all of low quality. CHM was superior in improving clinical symptoms to WM, with statistical significance between the groups (RR:1.36; 95% CI: 1.24-1.49); CHM plus WM was better than WM used alone (RR: 1.38; 95% CI:1.30-1.46). CHM improved lacrimal gland function more effectively than WM, with statistical significance between the groups (RR:2.12; 95% CI:1.06-3.18); CHM plus WM was better than WM used alone (RR:1.90; 95% CI: 0.99-2.81). CHM was superior to WM in the improvement of erythrocyte sedimentation rate (RR:-9.63; 95% CI:-15.73--3.52), and CHM plus WM was also more effective than WM used alone (RR:-8.42; 95% CI:-14.71--2.13). However, there was no statistical difference between groups in other immune index (C-reactive protein, rheumatoid factor, IgG, IgA and IgM). The reported adverse effects of CHM were mainly gastrointestinal symptoms, such as diarrhea. The incidence of adverse effects of WM was higher than that of CHM.

CONCLUSION

CHM appears to improve the symptoms of Sjogren's syndrome. However, due to the low quality of included studies, further well-designed multicenter and large-scale RCTs are still needed to evaluate the beneficial effects of CHM.

Authors+Show Affiliations

Center for Evidence-based Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

chi

PubMed ID

21419078

Citation

Luo, Hui, et al. "[Systematic Review and Meta-analysis of Randomized Controlled Trials of Chinese Herbal Medicine in the Treatment of Sjogren's Syndrome]." Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine, vol. 9, no. 3, 2011, pp. 257-74.
Luo H, Han M, Liu JP. [Systematic review and meta-analysis of randomized controlled trials of Chinese herbal medicine in the treatment of Sjogren's syndrome]. Zhong Xi Yi Jie He Xue Bao. 2011;9(3):257-74.
Luo, H., Han, M., & Liu, J. P. (2011). [Systematic review and meta-analysis of randomized controlled trials of Chinese herbal medicine in the treatment of Sjogren's syndrome]. Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine, 9(3), 257-74.
Luo H, Han M, Liu JP. [Systematic Review and Meta-analysis of Randomized Controlled Trials of Chinese Herbal Medicine in the Treatment of Sjogren's Syndrome]. Zhong Xi Yi Jie He Xue Bao. 2011;9(3):257-74. PubMed PMID: 21419078.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Systematic review and meta-analysis of randomized controlled trials of Chinese herbal medicine in the treatment of Sjogren's syndrome]. AU - Luo,Hui, AU - Han,Mei, AU - Liu,Jian-Ping, PY - 2011/3/23/entrez PY - 2011/3/23/pubmed PY - 2012/3/13/medline SP - 257 EP - 74 JF - Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine JO - Zhong Xi Yi Jie He Xue Bao VL - 9 IS - 3 N2 - BACKGROUND: Chinese herbal medicine (CHM) has been widely used in the treatment of Sjogren's syndrome. However, there remains no systematic review to assess the effectiveness and safety of CHM. OBJECTIVE: To assess the effectiveness and safety of CHM in the treatment of Sjogren's syndrome. SEARCH STRATEGY: Literature was searched from PubMed, the Cochrane Library (Issue 3, 2010), the China National Knowledge Infrastructure Database, the Chongqing VIP Chinese Science and Technology Periodical Database, the Chinese Biomedical Literature Database (SinoMed), Wanfang Data and the Traditional Chinese Medical Periodical Literature Database. The time limitation ran from the commencement of each database to October 15, 2010. INCLUSION CRITERIA: Randomized controlled trials (RCTs) testing CHM alone or in combination with Western medicine (WM) against WM or placebo used alone were included. DATA EXTRACTION AND ANALYSIS: Two authors collected data independently. The assessment of methodological quality was based on the Cochrane handbook and the data were analyzed by using RevMan 5.0.17 software. Heterogeneity of the included studies was tested and use of statistical model was based on the heterogeneity. The efficacy measure was relative risk (RR) or mean difference with a 95% confidence interval (CI). RESULTS: A total of 52 RCTs involving 3 886 patients were included. The included trials were all of low quality. CHM was superior in improving clinical symptoms to WM, with statistical significance between the groups (RR:1.36; 95% CI: 1.24-1.49); CHM plus WM was better than WM used alone (RR: 1.38; 95% CI:1.30-1.46). CHM improved lacrimal gland function more effectively than WM, with statistical significance between the groups (RR:2.12; 95% CI:1.06-3.18); CHM plus WM was better than WM used alone (RR:1.90; 95% CI: 0.99-2.81). CHM was superior to WM in the improvement of erythrocyte sedimentation rate (RR:-9.63; 95% CI:-15.73--3.52), and CHM plus WM was also more effective than WM used alone (RR:-8.42; 95% CI:-14.71--2.13). However, there was no statistical difference between groups in other immune index (C-reactive protein, rheumatoid factor, IgG, IgA and IgM). The reported adverse effects of CHM were mainly gastrointestinal symptoms, such as diarrhea. The incidence of adverse effects of WM was higher than that of CHM. CONCLUSION: CHM appears to improve the symptoms of Sjogren's syndrome. However, due to the low quality of included studies, further well-designed multicenter and large-scale RCTs are still needed to evaluate the beneficial effects of CHM. SN - 1672-1977 UR - https://www.unboundmedicine.com/medline/citation/21419078/[Systematic_review_and_meta_analysis_of_randomized_controlled_trials_of_Chinese_herbal_medicine_in_the_treatment_of_Sjogren's_syndrome]_ L2 - https://medlineplus.gov/herbalmedicine.html DB - PRIME DP - Unbound Medicine ER -