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Vitamin D as a T-cell modulator in multiple sclerosis.
Vitam Horm 2011; 86:401-28VH

Abstract

Vitamin D is a potent immune modulator, keeping the T-cell compartment in a more tolerogenic state. Multiple sclerosis (MS), a disease in which an autoreactive T-cell response contributes to inflammation in the central nervous system, has been associated with vitamin D deficiency. The effects of vitamin D on the immune system are believed to be an important driver of this association. In this chapter, we elaborate on vitamin D as a modulator of the T-cell response. This discussion will be placed in the perspective of MS as a T-cell-mediated disease and in the perspective of the numerous association studies on vitamin D deficiency and multiple health outcomes. We conclude that there is a firm experimental and epidemiological basis supporting the model of vitamin D as a physiological immune modulator, on which intervention studies assessing clinical and immunological outcome measures should be designed.

Authors+Show Affiliations

School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

21419282

Citation

Smolders, Joost, and Jan Damoiseaux. "Vitamin D as a T-cell Modulator in Multiple Sclerosis." Vitamins and Hormones, vol. 86, 2011, pp. 401-28.
Smolders J, Damoiseaux J. Vitamin D as a T-cell modulator in multiple sclerosis. Vitam Horm. 2011;86:401-28.
Smolders, J., & Damoiseaux, J. (2011). Vitamin D as a T-cell modulator in multiple sclerosis. Vitamins and Hormones, 86, pp. 401-28. doi:10.1016/B978-0-12-386960-9.00018-6.
Smolders J, Damoiseaux J. Vitamin D as a T-cell Modulator in Multiple Sclerosis. Vitam Horm. 2011;86:401-28. PubMed PMID: 21419282.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D as a T-cell modulator in multiple sclerosis. AU - Smolders,Joost, AU - Damoiseaux,Jan, PY - 2011/3/23/entrez PY - 2011/3/23/pubmed PY - 2011/7/16/medline SP - 401 EP - 28 JF - Vitamins and hormones JO - Vitam. Horm. VL - 86 N2 - Vitamin D is a potent immune modulator, keeping the T-cell compartment in a more tolerogenic state. Multiple sclerosis (MS), a disease in which an autoreactive T-cell response contributes to inflammation in the central nervous system, has been associated with vitamin D deficiency. The effects of vitamin D on the immune system are believed to be an important driver of this association. In this chapter, we elaborate on vitamin D as a modulator of the T-cell response. This discussion will be placed in the perspective of MS as a T-cell-mediated disease and in the perspective of the numerous association studies on vitamin D deficiency and multiple health outcomes. We conclude that there is a firm experimental and epidemiological basis supporting the model of vitamin D as a physiological immune modulator, on which intervention studies assessing clinical and immunological outcome measures should be designed. SN - 0083-6729 UR - https://www.unboundmedicine.com/medline/citation/21419282/Vitamin_D_as_a_T_cell_modulator_in_multiple_sclerosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/B978-0-12-386960-9.00018-6 DB - PRIME DP - Unbound Medicine ER -