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Insulin resistance is not strictly associated with energy intake or dietary macronutrient composition in women with polycystic ovary syndrome.
Nutr Res. 2011 Feb; 31(2):97-103.NR

Abstract

Polycystic ovary syndrome (PCOS) is a heterogeneous disorder characterized by hyperandrogenism and chronic anovulation. Around 60% of PCOS patients are obese. Weight loss has consistently been shown to improve the clinical status of women with PCOS. We hypothesized that dietary factors are associated with the hormonal and metabolic abnormalities of PCOS. This case-control study included 43 women with PCOS and 37 ovulatory, nonhirsute controls matched to the study group by body mass index. Age ranged from 14 to 38 years. Both groups underwent anthropometric, laboratory, and nutritional assessment. End points included diet composition, body fat, and hormonal and metabolic variables related to insulin resistance. The groups had similar intake of energy, carbohydrate (53.51% ± 8.36% vs 51.83% ± 10.06%), protein (15% [12-18] vs 16% [13-19]), and total fat (30.51% ± 7.90% vs 30.80% ± 7.97%). Total body fat, sum of trunk skinfold measurements, and waist circumference were higher in the PCOS group (P < .05). Sex hormone-binding globulin was lower in PCOS patients than in controls, whereas total testosterone, free androgen index, postprandial glucose, fasting and postprandial insulin, homeostatic model assessment index, triglycerides, and total and low-density lipoprotein cholesterol (P < .050) were higher. Homeostatic model assessment index was correlated with central obesity in PCOS patients and controls alike. No association was detected between androgen status and macronutrient intake. In conclusion, central obesity and insulin resistance were not strictly associated with energy intake or dietary macronutrient composition in women with PCOS.

Authors+Show Affiliations

Gynecological Endocrinology Unit, Division of Endocrinology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21419313

Citation

Toscani, Mariana K., et al. "Insulin Resistance Is Not Strictly Associated With Energy Intake or Dietary Macronutrient Composition in Women With Polycystic Ovary Syndrome." Nutrition Research (New York, N.Y.), vol. 31, no. 2, 2011, pp. 97-103.
Toscani MK, Mario FM, Radavelli-Bagatini S, et al. Insulin resistance is not strictly associated with energy intake or dietary macronutrient composition in women with polycystic ovary syndrome. Nutr Res. 2011;31(2):97-103.
Toscani, M. K., Mario, F. M., Radavelli-Bagatini, S., & Spritzer, P. M. (2011). Insulin resistance is not strictly associated with energy intake or dietary macronutrient composition in women with polycystic ovary syndrome. Nutrition Research (New York, N.Y.), 31(2), 97-103. https://doi.org/10.1016/j.nutres.2011.01.009
Toscani MK, et al. Insulin Resistance Is Not Strictly Associated With Energy Intake or Dietary Macronutrient Composition in Women With Polycystic Ovary Syndrome. Nutr Res. 2011;31(2):97-103. PubMed PMID: 21419313.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insulin resistance is not strictly associated with energy intake or dietary macronutrient composition in women with polycystic ovary syndrome. AU - Toscani,Mariana K, AU - Mario,Fernanda M, AU - Radavelli-Bagatini,Simone, AU - Spritzer,Poli Mara, PY - 2010/07/28/received PY - 2010/12/29/revised PY - 2011/01/24/accepted PY - 2011/3/23/entrez PY - 2011/3/23/pubmed PY - 2011/8/16/medline SP - 97 EP - 103 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 31 IS - 2 N2 - Polycystic ovary syndrome (PCOS) is a heterogeneous disorder characterized by hyperandrogenism and chronic anovulation. Around 60% of PCOS patients are obese. Weight loss has consistently been shown to improve the clinical status of women with PCOS. We hypothesized that dietary factors are associated with the hormonal and metabolic abnormalities of PCOS. This case-control study included 43 women with PCOS and 37 ovulatory, nonhirsute controls matched to the study group by body mass index. Age ranged from 14 to 38 years. Both groups underwent anthropometric, laboratory, and nutritional assessment. End points included diet composition, body fat, and hormonal and metabolic variables related to insulin resistance. The groups had similar intake of energy, carbohydrate (53.51% ± 8.36% vs 51.83% ± 10.06%), protein (15% [12-18] vs 16% [13-19]), and total fat (30.51% ± 7.90% vs 30.80% ± 7.97%). Total body fat, sum of trunk skinfold measurements, and waist circumference were higher in the PCOS group (P < .05). Sex hormone-binding globulin was lower in PCOS patients than in controls, whereas total testosterone, free androgen index, postprandial glucose, fasting and postprandial insulin, homeostatic model assessment index, triglycerides, and total and low-density lipoprotein cholesterol (P < .050) were higher. Homeostatic model assessment index was correlated with central obesity in PCOS patients and controls alike. No association was detected between androgen status and macronutrient intake. In conclusion, central obesity and insulin resistance were not strictly associated with energy intake or dietary macronutrient composition in women with PCOS. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/21419313/Insulin_resistance_is_not_strictly_associated_with_energy_intake_or_dietary_macronutrient_composition_in_women_with_polycystic_ovary_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(11)00017-0 DB - PRIME DP - Unbound Medicine ER -