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Effects of red mold dioscorea on oral carcinogenesis in DMBA-induced hamster animal model.
Food Chem Toxicol. 2011 Jun; 49(6):1292-7.FC

Abstract

Monascus-fermented products offer valuable therapeutic benefits and have been extensively used for centuries in East Asia. Dioscorea has been proved to have anti-cancer effect. The aim of this study is to investigate the anti-tumor ability of the ethanol extract of red mold dioscorea (RMDE) on 7,12-dimethyl-1,2-benz[a]anthracene (DMBA)-induced hamster buccal pouch carcinogenesis. We induced oral squamous cell carcinoma (OSCC) in the buccal pouch of male Syrian golden hamsters by painting with 0.5% DMBA three times a week for 14 weeks. From 9 to 14 weeks, a dose of 50, 100, and 200 mg RMDE per kg body weight were painting with the hamsters for 6 weeks on days alternate to the DMBA application. The results demonstrated that RMDE decreased nitric oxide (NO), reactive oxygen species (ROS), and prostaglandin E(2) (PGE(2)) overexpression in hamster buccal pouches in the DMBA treatment group and increased p53, serum tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) to significantly stimulate caspase-8 and -3 activities, indicating that RMDE reduced oxidative damage causing by DMBA and induced apoptosis in oral cancer cells. Therefore, RMDE may have therapeutic potentials against OSCC.

Authors+Show Affiliations

Department of Biochemical Science and Technology, College of Life Science, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21419818

Citation

Hsu, Wei-Hsuan, et al. "Effects of Red Mold Dioscorea On Oral Carcinogenesis in DMBA-induced Hamster Animal Model." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 49, no. 6, 2011, pp. 1292-7.
Hsu WH, Lee BH, Pan TM. Effects of red mold dioscorea on oral carcinogenesis in DMBA-induced hamster animal model. Food Chem Toxicol. 2011;49(6):1292-7.
Hsu, W. H., Lee, B. H., & Pan, T. M. (2011). Effects of red mold dioscorea on oral carcinogenesis in DMBA-induced hamster animal model. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 49(6), 1292-7. https://doi.org/10.1016/j.fct.2011.03.010
Hsu WH, Lee BH, Pan TM. Effects of Red Mold Dioscorea On Oral Carcinogenesis in DMBA-induced Hamster Animal Model. Food Chem Toxicol. 2011;49(6):1292-7. PubMed PMID: 21419818.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of red mold dioscorea on oral carcinogenesis in DMBA-induced hamster animal model. AU - Hsu,Wei-Hsuan, AU - Lee,Bao-Hong, AU - Pan,Tzu-Ming, Y1 - 2011/03/17/ PY - 2010/03/18/received PY - 2011/02/14/revised PY - 2011/03/10/accepted PY - 2011/3/23/entrez PY - 2011/3/23/pubmed PY - 2011/8/31/medline SP - 1292 EP - 7 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem. Toxicol. VL - 49 IS - 6 N2 - Monascus-fermented products offer valuable therapeutic benefits and have been extensively used for centuries in East Asia. Dioscorea has been proved to have anti-cancer effect. The aim of this study is to investigate the anti-tumor ability of the ethanol extract of red mold dioscorea (RMDE) on 7,12-dimethyl-1,2-benz[a]anthracene (DMBA)-induced hamster buccal pouch carcinogenesis. We induced oral squamous cell carcinoma (OSCC) in the buccal pouch of male Syrian golden hamsters by painting with 0.5% DMBA three times a week for 14 weeks. From 9 to 14 weeks, a dose of 50, 100, and 200 mg RMDE per kg body weight were painting with the hamsters for 6 weeks on days alternate to the DMBA application. The results demonstrated that RMDE decreased nitric oxide (NO), reactive oxygen species (ROS), and prostaglandin E(2) (PGE(2)) overexpression in hamster buccal pouches in the DMBA treatment group and increased p53, serum tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) to significantly stimulate caspase-8 and -3 activities, indicating that RMDE reduced oxidative damage causing by DMBA and induced apoptosis in oral cancer cells. Therefore, RMDE may have therapeutic potentials against OSCC. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/21419818/Effects_of_red_mold_dioscorea_on_oral_carcinogenesis_in_DMBA_induced_hamster_animal_model_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(11)00079-2 DB - PRIME DP - Unbound Medicine ER -