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The effects of cannabis use on neurocognition in schizophrenia: a meta-analysis.

Abstract

Patients with schizophrenia frequently report cannabis use, yet its effects on neurocognitive functioning in this population are still unclear. This meta-analysis was conducted to determine the magnitude of effect of cannabis consumption on cognition in schizophrenia without the confounding effects of other co-morbid substance use disorders. Eight studies met inclusion criteria yielding a total sample of 942. Three hundred and fifty six of these participants were cannabis users with schizophrenia, and 586 were patients with no cannabis use. Neuropsychological tests were grouped into seven domains (general cognitive ability and intelligence; selective, sustained and divided attention; executive abilities; working memory and learning; retrieval and recognition; receptive and expressive language abilities and visuo-spatial and construction abilities). Effect sizes were computed for each cognitive domain between cannabis-using patients and patients with no history of cannabis use. Effect size differences in cognitive performance in the schizophrenia group as a function of cannabis use were in the small to medium range, denoting superior performance in cannabis-using patients. Explanations for these findings are discussed and suggestions for future research in this area are recommended.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    The Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada. rachel_rabin@camh.net

    ,

    Source

    Schizophrenia research 128:1-3 2011 May pg 111-6

    MeSH

    Adult
    Cognition Disorders
    Female
    Humans
    Male
    Marijuana Abuse
    Meta-Analysis as Topic
    Neuropsychological Tests
    Schizophrenia
    Schizophrenic Psychology

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    21420282

    Citation

    Rabin, Rachel A., et al. "The Effects of Cannabis Use On Neurocognition in Schizophrenia: a Meta-analysis." Schizophrenia Research, vol. 128, no. 1-3, 2011, pp. 111-6.
    Rabin RA, Zakzanis KK, George TP. The effects of cannabis use on neurocognition in schizophrenia: a meta-analysis. Schizophr Res. 2011;128(1-3):111-6.
    Rabin, R. A., Zakzanis, K. K., & George, T. P. (2011). The effects of cannabis use on neurocognition in schizophrenia: a meta-analysis. Schizophrenia Research, 128(1-3), pp. 111-6. doi:10.1016/j.schres.2011.02.017.
    Rabin RA, Zakzanis KK, George TP. The Effects of Cannabis Use On Neurocognition in Schizophrenia: a Meta-analysis. Schizophr Res. 2011;128(1-3):111-6. PubMed PMID: 21420282.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The effects of cannabis use on neurocognition in schizophrenia: a meta-analysis. AU - Rabin,Rachel A, AU - Zakzanis,Konstantine K, AU - George,Tony P, Y1 - 2011/03/21/ PY - 2010/10/25/received PY - 2011/02/11/revised PY - 2011/02/16/accepted PY - 2011/3/23/entrez PY - 2011/3/23/pubmed PY - 2011/8/25/medline SP - 111 EP - 6 JF - Schizophrenia research JO - Schizophr. Res. VL - 128 IS - 1-3 N2 - Patients with schizophrenia frequently report cannabis use, yet its effects on neurocognitive functioning in this population are still unclear. This meta-analysis was conducted to determine the magnitude of effect of cannabis consumption on cognition in schizophrenia without the confounding effects of other co-morbid substance use disorders. Eight studies met inclusion criteria yielding a total sample of 942. Three hundred and fifty six of these participants were cannabis users with schizophrenia, and 586 were patients with no cannabis use. Neuropsychological tests were grouped into seven domains (general cognitive ability and intelligence; selective, sustained and divided attention; executive abilities; working memory and learning; retrieval and recognition; receptive and expressive language abilities and visuo-spatial and construction abilities). Effect sizes were computed for each cognitive domain between cannabis-using patients and patients with no history of cannabis use. Effect size differences in cognitive performance in the schizophrenia group as a function of cannabis use were in the small to medium range, denoting superior performance in cannabis-using patients. Explanations for these findings are discussed and suggestions for future research in this area are recommended. SN - 1573-2509 UR - https://www.unboundmedicine.com/medline/citation/21420282/The_effects_of_cannabis_use_on_neurocognition_in_schizophrenia:_a_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0920-9964(11)00137-X DB - PRIME DP - Unbound Medicine ER -