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Anti-inflammatory activity of Lychnophora passerina, Asteraceae (Brazilian "Arnica").
J Ethnopharmacol. 2011 May 17; 135(2):393-8.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Lychnophora passerina (Asteraceae), popularly known as "arnica," is used to treat inflammation, pain, rheumatism, contusions, bruises and insect bites in Brazilian traditional medicine.

MATERIALS AND METHODS

The anti-inflammatory activity of crude ethanolic extract of aerial parts of L. passerina and its ethyl acetate and methanolic fractions had their abilities to modulate the production of NO, TNF-α and IL-10 inflammatory mediators in LPS/IFN-γ-stimulated J774.A1 macrophages evaluated. Moreover, the crude ethanolic extract and derived fractions were also in vivo assayed by carrageenan-induced paw oedema in mice.

RESULTS

In vitro assays showed remarkable anti-inflammatory activity of L. passerina crude ethanolic extract (EE) and its ethyl acetate (A) and methanolic (M) fractions, through the inhibition of production of NO and TNF-α inflammatory mediators and induction of production of IL-10 anti-inflammatory cytokine. In vivo assays showed anti-inflammatory activity for EE 10% ointment, similar to the standard drug diclofenac gel. The A and M fraction ointments 20% presented anti-inflammatory activity.

CONCLUSION

The results obtained showed that possible anti-inflammatory effects of EE and its A and M fractions may be attributed to inhibition pro-inflammatory cytokines production, TNF-α and NO and to increased IL-10 production. EE, A and M ointments showed topical in vivo anti-inflammatory activity. The in vivo anti-inflammatory activity of EE of L. passerina may be related to synergistic effects of different substances in the crude extract. Therefore, traditional use of aerial parts of L. passerina in the inflammatory conditions could be beneficial to treat topical inflammatory conditions, as evidenced by the present study.

Authors+Show Affiliations

Laboratório de Plantas Medicinais, Escola de Farmácia, Universidade Federal de Ouro Preto, Minas Gerais, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21420480

Citation

Capelari-Oliveira, P, et al. "Anti-inflammatory Activity of Lychnophora Passerina, Asteraceae (Brazilian "Arnica")." Journal of Ethnopharmacology, vol. 135, no. 2, 2011, pp. 393-8.
Capelari-Oliveira P, Paula CA, Rezende SA, et al. Anti-inflammatory activity of Lychnophora passerina, Asteraceae (Brazilian "Arnica"). J Ethnopharmacol. 2011;135(2):393-8.
Capelari-Oliveira, P., Paula, C. A., Rezende, S. A., Campos, F. T., Grabe-Guimarães, A., Lombardi, J. A., & Saúde-Guimarães, D. A. (2011). Anti-inflammatory activity of Lychnophora passerina, Asteraceae (Brazilian "Arnica"). Journal of Ethnopharmacology, 135(2), 393-8. https://doi.org/10.1016/j.jep.2011.03.034
Capelari-Oliveira P, et al. Anti-inflammatory Activity of Lychnophora Passerina, Asteraceae (Brazilian "Arnica"). J Ethnopharmacol. 2011 May 17;135(2):393-8. PubMed PMID: 21420480.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory activity of Lychnophora passerina, Asteraceae (Brazilian "Arnica"). AU - Capelari-Oliveira,P, AU - Paula,C A, AU - Rezende,S A, AU - Campos,F T, AU - Grabe-Guimarães,A, AU - Lombardi,J A, AU - Saúde-Guimarães,D A, Y1 - 2011/03/21/ PY - 2010/12/11/received PY - 2011/02/27/revised PY - 2011/03/12/accepted PY - 2011/3/23/entrez PY - 2011/3/23/pubmed PY - 2011/9/8/medline SP - 393 EP - 8 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 135 IS - 2 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Lychnophora passerina (Asteraceae), popularly known as "arnica," is used to treat inflammation, pain, rheumatism, contusions, bruises and insect bites in Brazilian traditional medicine. MATERIALS AND METHODS: The anti-inflammatory activity of crude ethanolic extract of aerial parts of L. passerina and its ethyl acetate and methanolic fractions had their abilities to modulate the production of NO, TNF-α and IL-10 inflammatory mediators in LPS/IFN-γ-stimulated J774.A1 macrophages evaluated. Moreover, the crude ethanolic extract and derived fractions were also in vivo assayed by carrageenan-induced paw oedema in mice. RESULTS: In vitro assays showed remarkable anti-inflammatory activity of L. passerina crude ethanolic extract (EE) and its ethyl acetate (A) and methanolic (M) fractions, through the inhibition of production of NO and TNF-α inflammatory mediators and induction of production of IL-10 anti-inflammatory cytokine. In vivo assays showed anti-inflammatory activity for EE 10% ointment, similar to the standard drug diclofenac gel. The A and M fraction ointments 20% presented anti-inflammatory activity. CONCLUSION: The results obtained showed that possible anti-inflammatory effects of EE and its A and M fractions may be attributed to inhibition pro-inflammatory cytokines production, TNF-α and NO and to increased IL-10 production. EE, A and M ointments showed topical in vivo anti-inflammatory activity. The in vivo anti-inflammatory activity of EE of L. passerina may be related to synergistic effects of different substances in the crude extract. Therefore, traditional use of aerial parts of L. passerina in the inflammatory conditions could be beneficial to treat topical inflammatory conditions, as evidenced by the present study. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/21420480/Anti_inflammatory_activity_of_Lychnophora_passerina_Asteraceae__Brazilian_"Arnica"__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(11)00170-X DB - PRIME DP - Unbound Medicine ER -