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Serotonin-1A receptors in the dorsal periaqueductal gray matter mediate the panicolytic-like effect of pindolol and paroxetine combination in the elevated T-maze.
Neurosci Lett 2011; 495(1):63-6NL

Abstract

The β-adrenergic blocker and 5-HT(1A) receptor antagonist pindolol has been combined with selective serotonin reuptake inhibitors (SSRIs) in patients with depressive and anxiety disorders to shorten the onset of the clinical action and/or increase the proportion of responders. The results of a previous study have shown that pindolol potentiates the panicolytic effect of paroxetine in rats submitted to the elevated T-maze (ETM). Since reported evidence has implicated the 5-HT(1A) receptors of the dorsal periaqueductal gray matter (DPAG) in the panicolytic effect of antidepressants, rats treated with pindolol (5.0mg/kg, i.p.) and paroxetine (1.5mg/kg, i.p.) received a previous intra-DPAG injection of the selective 5-HT(1A) antagonist, WAY-100635 (0.4 μg) and were submitted to the ETM. Pretreatment with WAY-100635 reversed the increase in escape latency, a panicolytic effect, determined by the pindolol-paroxetine combination. These results implicate the 5-HT(1A) receptors of the DPAG in the panicolytic effect of the pindolol-paroxetine combination administered systemically. They also give further preclinical support for the use of this drug combination in the treatment of panic disorder.

Authors+Show Affiliations

Department of Pharmacology and Therapeutic, State University of Maringá, Av. Colombo, 5790 - Jardim Universitário, CEP: 87020900 Maringá, PR, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21421022

Citation

Sela, Vânia Ramos, et al. "Serotonin-1A Receptors in the Dorsal Periaqueductal Gray Matter Mediate the Panicolytic-like Effect of Pindolol and Paroxetine Combination in the Elevated T-maze." Neuroscience Letters, vol. 495, no. 1, 2011, pp. 63-6.
Sela VR, Biesdorf C, Ramos DH, et al. Serotonin-1A receptors in the dorsal periaqueductal gray matter mediate the panicolytic-like effect of pindolol and paroxetine combination in the elevated T-maze. Neurosci Lett. 2011;495(1):63-6.
Sela, V. R., Biesdorf, C., Ramos, D. H., Zangrossi, H., Graeff, F. G., & Audi, E. A. (2011). Serotonin-1A receptors in the dorsal periaqueductal gray matter mediate the panicolytic-like effect of pindolol and paroxetine combination in the elevated T-maze. Neuroscience Letters, 495(1), pp. 63-6. doi:10.1016/j.neulet.2011.03.040.
Sela VR, et al. Serotonin-1A Receptors in the Dorsal Periaqueductal Gray Matter Mediate the Panicolytic-like Effect of Pindolol and Paroxetine Combination in the Elevated T-maze. Neurosci Lett. 2011 May 9;495(1):63-6. PubMed PMID: 21421022.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serotonin-1A receptors in the dorsal periaqueductal gray matter mediate the panicolytic-like effect of pindolol and paroxetine combination in the elevated T-maze. AU - Sela,Vânia Ramos, AU - Biesdorf,Carla, AU - Ramos,Diego Henrique, AU - Zangrossi,Hélio,Jr AU - Graeff,Frederico Guilherme, AU - Audi,Elisabeth Aparecida, Y1 - 2011/03/21/ PY - 2010/12/22/received PY - 2011/03/09/revised PY - 2011/03/13/accepted PY - 2011/3/23/entrez PY - 2011/3/23/pubmed PY - 2011/9/14/medline SP - 63 EP - 6 JF - Neuroscience letters JO - Neurosci. Lett. VL - 495 IS - 1 N2 - The β-adrenergic blocker and 5-HT(1A) receptor antagonist pindolol has been combined with selective serotonin reuptake inhibitors (SSRIs) in patients with depressive and anxiety disorders to shorten the onset of the clinical action and/or increase the proportion of responders. The results of a previous study have shown that pindolol potentiates the panicolytic effect of paroxetine in rats submitted to the elevated T-maze (ETM). Since reported evidence has implicated the 5-HT(1A) receptors of the dorsal periaqueductal gray matter (DPAG) in the panicolytic effect of antidepressants, rats treated with pindolol (5.0mg/kg, i.p.) and paroxetine (1.5mg/kg, i.p.) received a previous intra-DPAG injection of the selective 5-HT(1A) antagonist, WAY-100635 (0.4 μg) and were submitted to the ETM. Pretreatment with WAY-100635 reversed the increase in escape latency, a panicolytic effect, determined by the pindolol-paroxetine combination. These results implicate the 5-HT(1A) receptors of the DPAG in the panicolytic effect of the pindolol-paroxetine combination administered systemically. They also give further preclinical support for the use of this drug combination in the treatment of panic disorder. SN - 1872-7972 UR - https://www.unboundmedicine.com/medline/citation/21421022/Serotonin_1A_receptors_in_the_dorsal_periaqueductal_gray_matter_mediate_the_panicolytic_like_effect_of_pindolol_and_paroxetine_combination_in_the_elevated_T_maze_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(11)00332-6 DB - PRIME DP - Unbound Medicine ER -