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Loss of the low-frequency component of the global-flash multifocal electroretinogram in primate eyes with experimental glaucoma.
Invest Ophthalmol Vis Sci. 2011 Jun 01; 52(6):3792-804.IO

Abstract

PURPOSE

To study relationships between glaucoma-sensitive components identified with frequency-domain analysis of global-flash multifocal electroretinogram (mfERG), regional retinal nerve fiber layer thickness (RNFLT), and local visual field sensitivity (VS).

METHODS

Eleven macaque monkeys, including four controls and seven with unilateral laser-induced trabecular meshwork scarification and ocular hypertension, were observed with optical coherence tomography (OCT), full-field light-adapted flash ERG, 103-hexagon global-flash mfERG (MFOFO), and static perimetry. The effects of experimental glaucoma on mfERG were assessed in the frequency domain. Relations between root mean square (RMS) amplitude of a glaucoma-sensitive frequency range and peripapillary RNFLT (standard 12° OCT circular scan), and between RMS amplitude and VS were studied.

RESULTS

Experimental glaucoma led to a dramatic and consistent power loss in the low-frequency (<25 Hz) band of mfERG. The RMS of this low-frequency component (LFC) correlated significantly with the regional RNFLT. The r(2) of linear fits was 0.39 (P < 0.001) for cross-sectional group data and 0.60 after correction for intersubject variability. The r(2) of linear fits for longitudinal data from individual animals was as high as 0.78 (P < 0.001). Local LFC RMS amplitude also correlated significantly with interpolated VS for hexagons. The r(2) for exponential fits of hexagon LFC RMS amplitudes (inner three rings) versus VS (dB) was 0.29 to 0.52 (P < 0.001) for the group and up to 0.95 in individuals.

CONCLUSIONS

The significant correlations between regional measures of global-flash mfERG, RNFLT, and VS suggest that LFC RMS amplitude provides a useful index for objective quantification of local RGC function and monitoring of early changes in glaucoma.

Authors+Show Affiliations

College of Optometry, University of Houston, Houston, Texas 77204-2020, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

21421870

Citation

Luo, Xunda, et al. "Loss of the Low-frequency Component of the Global-flash Multifocal Electroretinogram in Primate Eyes With Experimental Glaucoma." Investigative Ophthalmology & Visual Science, vol. 52, no. 6, 2011, pp. 3792-804.
Luo X, Patel NB, Harwerth RS, et al. Loss of the low-frequency component of the global-flash multifocal electroretinogram in primate eyes with experimental glaucoma. Invest Ophthalmol Vis Sci. 2011;52(6):3792-804.
Luo, X., Patel, N. B., Harwerth, R. S., & Frishman, L. J. (2011). Loss of the low-frequency component of the global-flash multifocal electroretinogram in primate eyes with experimental glaucoma. Investigative Ophthalmology & Visual Science, 52(6), 3792-804. https://doi.org/10.1167/iovs.10-6667
Luo X, et al. Loss of the Low-frequency Component of the Global-flash Multifocal Electroretinogram in Primate Eyes With Experimental Glaucoma. Invest Ophthalmol Vis Sci. 2011 Jun 1;52(6):3792-804. PubMed PMID: 21421870.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Loss of the low-frequency component of the global-flash multifocal electroretinogram in primate eyes with experimental glaucoma. AU - Luo,Xunda, AU - Patel,Nimesh B, AU - Harwerth,Ronald S, AU - Frishman,Laura J, Y1 - 2011/06/01/ PY - 2011/3/23/entrez PY - 2011/3/23/pubmed PY - 2011/8/20/medline SP - 3792 EP - 804 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 52 IS - 6 N2 - PURPOSE: To study relationships between glaucoma-sensitive components identified with frequency-domain analysis of global-flash multifocal electroretinogram (mfERG), regional retinal nerve fiber layer thickness (RNFLT), and local visual field sensitivity (VS). METHODS: Eleven macaque monkeys, including four controls and seven with unilateral laser-induced trabecular meshwork scarification and ocular hypertension, were observed with optical coherence tomography (OCT), full-field light-adapted flash ERG, 103-hexagon global-flash mfERG (MFOFO), and static perimetry. The effects of experimental glaucoma on mfERG were assessed in the frequency domain. Relations between root mean square (RMS) amplitude of a glaucoma-sensitive frequency range and peripapillary RNFLT (standard 12° OCT circular scan), and between RMS amplitude and VS were studied. RESULTS: Experimental glaucoma led to a dramatic and consistent power loss in the low-frequency (<25 Hz) band of mfERG. The RMS of this low-frequency component (LFC) correlated significantly with the regional RNFLT. The r(2) of linear fits was 0.39 (P < 0.001) for cross-sectional group data and 0.60 after correction for intersubject variability. The r(2) of linear fits for longitudinal data from individual animals was as high as 0.78 (P < 0.001). Local LFC RMS amplitude also correlated significantly with interpolated VS for hexagons. The r(2) for exponential fits of hexagon LFC RMS amplitudes (inner three rings) versus VS (dB) was 0.29 to 0.52 (P < 0.001) for the group and up to 0.95 in individuals. CONCLUSIONS: The significant correlations between regional measures of global-flash mfERG, RNFLT, and VS suggest that LFC RMS amplitude provides a useful index for objective quantification of local RGC function and monitoring of early changes in glaucoma. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/21421870/Loss_of_the_low_frequency_component_of_the_global_flash_multifocal_electroretinogram_in_primate_eyes_with_experimental_glaucoma_ L2 - https://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.10-6667 DB - PRIME DP - Unbound Medicine ER -