Tags

Type your tag names separated by a space and hit enter

Quetiapine, olanzapine and haloperidol affect human plasma lipid peroxidation in vitro.
Neuropsychobiology 2011; 63(4):197-201N

Abstract

OBJECTIVE

Oxidative injury in schizophrenia may be caused not only by pathophysiological processes but partly also by treatment with antipsychotics. The purpose of the present study was to examine and to compare the effects of quetiapine (QUE), olanzapine (OLA) and haloperidol (HAL), at final concentrations corresponding to doses used for treatment of acute episodes of schizophrenia, on plasma lipid peroxidation in vitro, measured by the level of thiobarbituric acid-reactive substances (TBARS).

METHODS

Blood from 30 healthy volunteers was collected into ACD (citric acid/citrate/dextrose) solution. The drugs in form of active substances were dissolved in 0.01% dimethyl sulfoxide, added to plasma at the final concentrations [QUE (175 and 275 ng/ml), OLA (20 and 40 ng/ml), HAL (4 and 20 ng/ml)] and incubated for 1 and 24 h at 37 °C. The level of TBARS was measured spectrophotometrically (according to the Rice-Evans method, 1991).

RESULTS

The comparative study in vitro showed that QUE causes a decrease in the TBARS level in plasma, whereas HAL increases the plasma TBARS level. After 24 h of incubation of plasma with QUE or HAL (at lower and higher concentrations),thedifferences in TBARS levels between the drugs were significant (p = 5.9 × 10⁻⁴, p = 2.2 × 10⁻⁵, respectively).

CONCLUSION

QUE and OLA, contrary to the prooxidative action of HAL, did not induce oxidative stress; moreover, QUE has antioxidant properties.

Authors+Show Affiliations

Department of Affective and Psychotic Disorders, Medical University of Lodz, Lodz, Poland. tzn_lodz @ post.plNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21422766

Citation

Dietrich-Muszalska, Anna, et al. "Quetiapine, Olanzapine and Haloperidol Affect Human Plasma Lipid Peroxidation in Vitro." Neuropsychobiology, vol. 63, no. 4, 2011, pp. 197-201.
Dietrich-Muszalska A, Kontek B, Rabe-Jabłońska J. Quetiapine, olanzapine and haloperidol affect human plasma lipid peroxidation in vitro. Neuropsychobiology. 2011;63(4):197-201.
Dietrich-Muszalska, A., Kontek, B., & Rabe-Jabłońska, J. (2011). Quetiapine, olanzapine and haloperidol affect human plasma lipid peroxidation in vitro. Neuropsychobiology, 63(4), pp. 197-201. doi:10.1159/000321623.
Dietrich-Muszalska A, Kontek B, Rabe-Jabłońska J. Quetiapine, Olanzapine and Haloperidol Affect Human Plasma Lipid Peroxidation in Vitro. Neuropsychobiology. 2011;63(4):197-201. PubMed PMID: 21422766.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quetiapine, olanzapine and haloperidol affect human plasma lipid peroxidation in vitro. AU - Dietrich-Muszalska,Anna, AU - Kontek,Bogdan, AU - Rabe-Jabłońska,Jolanta, Y1 - 2011/03/22/ PY - 2009/05/01/received PY - 2010/09/27/accepted PY - 2011/3/23/entrez PY - 2011/3/23/pubmed PY - 2011/9/14/medline SP - 197 EP - 201 JF - Neuropsychobiology JO - Neuropsychobiology VL - 63 IS - 4 N2 - OBJECTIVE: Oxidative injury in schizophrenia may be caused not only by pathophysiological processes but partly also by treatment with antipsychotics. The purpose of the present study was to examine and to compare the effects of quetiapine (QUE), olanzapine (OLA) and haloperidol (HAL), at final concentrations corresponding to doses used for treatment of acute episodes of schizophrenia, on plasma lipid peroxidation in vitro, measured by the level of thiobarbituric acid-reactive substances (TBARS). METHODS: Blood from 30 healthy volunteers was collected into ACD (citric acid/citrate/dextrose) solution. The drugs in form of active substances were dissolved in 0.01% dimethyl sulfoxide, added to plasma at the final concentrations [QUE (175 and 275 ng/ml), OLA (20 and 40 ng/ml), HAL (4 and 20 ng/ml)] and incubated for 1 and 24 h at 37 °C. The level of TBARS was measured spectrophotometrically (according to the Rice-Evans method, 1991). RESULTS: The comparative study in vitro showed that QUE causes a decrease in the TBARS level in plasma, whereas HAL increases the plasma TBARS level. After 24 h of incubation of plasma with QUE or HAL (at lower and higher concentrations),thedifferences in TBARS levels between the drugs were significant (p = 5.9 × 10⁻⁴, p = 2.2 × 10⁻⁵, respectively). CONCLUSION: QUE and OLA, contrary to the prooxidative action of HAL, did not induce oxidative stress; moreover, QUE has antioxidant properties. SN - 1423-0224 UR - https://www.unboundmedicine.com/medline/citation/21422766/Quetiapine_olanzapine_and_haloperidol_affect_human_plasma_lipid_peroxidation_in_vitro_ L2 - https://www.karger.com?DOI=10.1159/000321623 DB - PRIME DP - Unbound Medicine ER -