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Intake of high-intensity sweeteners alters the ability of sweet taste to signal caloric consequences: implications for the learned control of energy and body weight regulation.

Abstract

Recent results from both human epidemiological and experimental studies with animals suggest that intake of noncaloric sweeteners may promote, rather than protect against, weight gain and other disturbances of energy regulation. However, without a viable mechanism to explain how consumption of noncaloric sweeteners can increase energy intake and body weight, the persuasiveness of such results has been limited. Using a rat model, the present research showed that intake of noncaloric sweeteners reduces the effectiveness of learned associations between sweet tastes and postingestive caloric outcomes (Experiment 1) and that interfering with this association may impair the ability of rats to regulate their intake of sweet, but not nonsweet, high-fat and high-calorie food (Experiment 2). The results support the hypothesis that consuming noncaloric sweeteners may promote excessive intake and body weight gain by weakening a predictive relationship between sweet taste and the caloric consequences of eating.

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  • Authors+Show Affiliations

    ,

    Department of Psychological Sciences, Purdue University, West Lafayette, IN 47907, USA. tdavidso@purdue.edu

    , ,

    Source

    MeSH

    Animals
    Body Weight
    Eating
    Energy Intake
    Energy Metabolism
    Food Preferences
    Male
    Rats
    Rats, Sprague-Dawley
    Sweetening Agents
    Weight Gain

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    21424985

    Citation

    Davidson, Terry L., et al. "Intake of High-intensity Sweeteners Alters the Ability of Sweet Taste to Signal Caloric Consequences: Implications for the Learned Control of Energy and Body Weight Regulation." Quarterly Journal of Experimental Psychology (2006), vol. 64, no. 7, 2011, pp. 1430-41.
    Davidson TL, Martin AA, Clark K, et al. Intake of high-intensity sweeteners alters the ability of sweet taste to signal caloric consequences: implications for the learned control of energy and body weight regulation. Q J Exp Psychol (Hove). 2011;64(7):1430-41.
    Davidson, T. L., Martin, A. A., Clark, K., & Swithers, S. E. (2011). Intake of high-intensity sweeteners alters the ability of sweet taste to signal caloric consequences: implications for the learned control of energy and body weight regulation. Quarterly Journal of Experimental Psychology (2006), 64(7), pp. 1430-41. doi:10.1080/17470218.2011.552729.
    Davidson TL, et al. Intake of High-intensity Sweeteners Alters the Ability of Sweet Taste to Signal Caloric Consequences: Implications for the Learned Control of Energy and Body Weight Regulation. Q J Exp Psychol (Hove). 2011;64(7):1430-41. PubMed PMID: 21424985.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Intake of high-intensity sweeteners alters the ability of sweet taste to signal caloric consequences: implications for the learned control of energy and body weight regulation. AU - Davidson,Terry L, AU - Martin,Ashley A, AU - Clark,Kiely, AU - Swithers,Susan E, PY - 2011/3/23/entrez PY - 2011/3/23/pubmed PY - 2011/11/16/medline SP - 1430 EP - 41 JF - Quarterly journal of experimental psychology (2006) JO - Q J Exp Psychol (Hove) VL - 64 IS - 7 N2 - Recent results from both human epidemiological and experimental studies with animals suggest that intake of noncaloric sweeteners may promote, rather than protect against, weight gain and other disturbances of energy regulation. However, without a viable mechanism to explain how consumption of noncaloric sweeteners can increase energy intake and body weight, the persuasiveness of such results has been limited. Using a rat model, the present research showed that intake of noncaloric sweeteners reduces the effectiveness of learned associations between sweet tastes and postingestive caloric outcomes (Experiment 1) and that interfering with this association may impair the ability of rats to regulate their intake of sweet, but not nonsweet, high-fat and high-calorie food (Experiment 2). The results support the hypothesis that consuming noncaloric sweeteners may promote excessive intake and body weight gain by weakening a predictive relationship between sweet taste and the caloric consequences of eating. SN - 1747-0226 UR - https://www.unboundmedicine.com/medline/citation/21424985/Intake_of_high_intensity_sweeteners_alters_the_ability_of_sweet_taste_to_signal_caloric_consequences:_implications_for_the_learned_control_of_energy_and_body_weight_regulation_ L2 - http://journals.sagepub.com/doi/full/10.1080/17470218.2011.552729?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -