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Outcomes of endoscopic transpapillary gallbladder stenting for symptomatic gallbladder diseases: a multicenter prospective follow-up study.
Endoscopy. 2011 Aug; 43(8):702-8.E

Abstract

BACKGROUND AND STUDY AIMS

Endoscopic transpapillary gallbladder drainage for symptomatic gallbladder disease is a safe and effective bridge therapy in patients at high risk for surgery or who have terminal liver disease and are awaiting transplantation. However, there are few reports on long-term results in terms of stent patency and clinical course. Our study was designed to investigate the long-term patency and clinical course after endoscopic transpapillary gallbladder stenting (ETGS) in patients with symptomatic gallbladder disease.

PATIENTS AND METHODS

A total of 29 patients who were unsuitable for cholecystectomy underwent ETGS from June 2006 to March 2010 using a 7-Fr double-pigtail stent between the gallbladder and the duodenum. Their clinical progress, adverse events, and stent patency after ETGS were recorded prospectively in two tertiary referral centers.

RESULTS

Technically, ETGS was successful in 23 (79.3%) of the 29 patients. The mean procedure time was 22.4 ± 11.5 min. Postprocedure adverse events were mild pancreatitis (8.7%) and cholestasis (8.7%), all of which resolved with conservative management. During the follow-up period (median 586 days, range 11-1403 days), 20 patients were analyzed as per protocol, and scheduled follow-up was performed. Late adverse events developed in four patients (20%), including distal migration (n = 2), cholangitis (n = 1), and recurrent biliary pain (n = 1). The remaining 16 patients were followed for more than 12 months (nine patients were followed for more than 24 months). Median stent patency was 760 days, as determined by the Kaplan-Meier method.

CONCLUSIONS

As a primary therapy, ETGS is technically feasible and effective in patients who are unsuitable for cholecystectomy. ETGS may also provide long-term stent patency without the need for scheduled stent exchanges.

Authors+Show Affiliations

Department of Internal Medicine, Soon chun Hyang University College of Medicine, Cheonan Hospital, Cheonan, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study

Language

eng

PubMed ID

21425042

Citation

Lee, T H., et al. "Outcomes of Endoscopic Transpapillary Gallbladder Stenting for Symptomatic Gallbladder Diseases: a Multicenter Prospective Follow-up Study." Endoscopy, vol. 43, no. 8, 2011, pp. 702-8.
Lee TH, Park DH, Lee SS, et al. Outcomes of endoscopic transpapillary gallbladder stenting for symptomatic gallbladder diseases: a multicenter prospective follow-up study. Endoscopy. 2011;43(8):702-8.
Lee, T. H., Park, D. H., Lee, S. S., Seo, D. W., Park, S. H., Lee, S. K., Kim, M. H., & Kim, S. J. (2011). Outcomes of endoscopic transpapillary gallbladder stenting for symptomatic gallbladder diseases: a multicenter prospective follow-up study. Endoscopy, 43(8), 702-8. https://doi.org/10.1055/s-0030-1256226
Lee TH, et al. Outcomes of Endoscopic Transpapillary Gallbladder Stenting for Symptomatic Gallbladder Diseases: a Multicenter Prospective Follow-up Study. Endoscopy. 2011;43(8):702-8. PubMed PMID: 21425042.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Outcomes of endoscopic transpapillary gallbladder stenting for symptomatic gallbladder diseases: a multicenter prospective follow-up study. AU - Lee,T H, AU - Park,D H, AU - Lee,S S, AU - Seo,D W, AU - Park,S H, AU - Lee,S K, AU - Kim,M H, AU - Kim,S J, Y1 - 2011/03/21/ PY - 2011/3/23/entrez PY - 2011/3/23/pubmed PY - 2012/1/11/medline SP - 702 EP - 8 JF - Endoscopy JO - Endoscopy VL - 43 IS - 8 N2 - BACKGROUND AND STUDY AIMS: Endoscopic transpapillary gallbladder drainage for symptomatic gallbladder disease is a safe and effective bridge therapy in patients at high risk for surgery or who have terminal liver disease and are awaiting transplantation. However, there are few reports on long-term results in terms of stent patency and clinical course. Our study was designed to investigate the long-term patency and clinical course after endoscopic transpapillary gallbladder stenting (ETGS) in patients with symptomatic gallbladder disease. PATIENTS AND METHODS: A total of 29 patients who were unsuitable for cholecystectomy underwent ETGS from June 2006 to March 2010 using a 7-Fr double-pigtail stent between the gallbladder and the duodenum. Their clinical progress, adverse events, and stent patency after ETGS were recorded prospectively in two tertiary referral centers. RESULTS: Technically, ETGS was successful in 23 (79.3%) of the 29 patients. The mean procedure time was 22.4 ± 11.5 min. Postprocedure adverse events were mild pancreatitis (8.7%) and cholestasis (8.7%), all of which resolved with conservative management. During the follow-up period (median 586 days, range 11-1403 days), 20 patients were analyzed as per protocol, and scheduled follow-up was performed. Late adverse events developed in four patients (20%), including distal migration (n = 2), cholangitis (n = 1), and recurrent biliary pain (n = 1). The remaining 16 patients were followed for more than 12 months (nine patients were followed for more than 24 months). Median stent patency was 760 days, as determined by the Kaplan-Meier method. CONCLUSIONS: As a primary therapy, ETGS is technically feasible and effective in patients who are unsuitable for cholecystectomy. ETGS may also provide long-term stent patency without the need for scheduled stent exchanges. SN - 1438-8812 UR - https://www.unboundmedicine.com/medline/citation/21425042/Outcomes_of_endoscopic_transpapillary_gallbladder_stenting_for_symptomatic_gallbladder_diseases:_a_multicenter_prospective_follow_up_study_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0030-1256226 DB - PRIME DP - Unbound Medicine ER -