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[Antimicrobial susceptibility of clinical isolates of aerobic Gram-positive cocci and anaerobic bacteria in 2006].
Jpn J Antibiot. 2010 Dec; 63(6):431-56.JJ

Abstract

The activity of antibacterial agents against aerobic Gram-positive cocci (26 species, 1022 strains) and anaerobic bacteria (23 species, 184 strains) isolated from clinical specimens in 2006 at 16 clinical facilities in Japan were studied using either broth microdilution or agar dilution method. The ratio of methicillin-resistant strains among Staphylococcus aureus and Staphylococcus epidermidis was 53.0% and 65.8%, suggesting that resistant strains were isolated at high frequency. Vancomycin (VCM) and quinupristin/dalfopristin (QPR/DPR) had good antibacterial activity against methicillin-resistant S. aureus and methicillin-resistant S. epidermidis, with MIC90s of < or = 2 micrcog/mL. The ratio of penicillin (PC) intermediate and resistant strains classified by mutations of PC-binding proteins among Streptococcus pneumoniae was 87.6%. Ceftriaxone, cefpirome, cefepime, carbapenem antibiotics, VCM, teicoplanin, linezolid(LZD) and QPR/DPR had MIC90s of < or = 1 microg/mL against PC-intermediate and resistant S. pneumoniae strains. Against all strains of Enterococcus faecalis and Enterococcus faecium, the MICs of VCM and TEIC were under 2 microg/mL, and no resistant strain was detected, suggesting that these agents had excellent activities against these species. 10.9% of E. faecalis strains or 3.5% of E. faecium strains showed intermediate or resistant to LZD. 24.4% of E. faecium strains showed intermediate or resistant to QPR/DPR. Against all strains of Clostridium difficile, the MIC of VCM were under 1 microg/mL, suggesting that VCM had excellent activity against C. difficile. Carbapenems showed good activity against Peptococcaceae, Bacteroides spp., and Prevotella spp. However since several strains of Bacteroides fragilis showed resistant to carbapenems and the susceptibility of this species should be well-focused in the future.

Authors+Show Affiliations

Developmental Research Laboratories, Shionogi & Co., Ltd., 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

jpn

PubMed ID

21425596

Citation

Yamaguchi, Takahiro, et al. "[Antimicrobial Susceptibility of Clinical Isolates of Aerobic Gram-positive Cocci and Anaerobic Bacteria in 2006]." The Japanese Journal of Antibiotics, vol. 63, no. 6, 2010, pp. 431-56.
Yamaguchi T, Yoshida I, Itoh Y, et al. [Antimicrobial susceptibility of clinical isolates of aerobic Gram-positive cocci and anaerobic bacteria in 2006]. Jpn J Antibiot. 2010;63(6):431-56.
Yamaguchi, T., Yoshida, I., Itoh, Y., Tachibana, M., Takahashi, C., Kaku, M., Kanemitsu, K., Okada, M., Horikawa, Y., Shiotani, J., Kino, H., Ono, Y., Baba, H., Matsuo, S., Asari, S., Toyokawa, M., Matsuoka, K., Kusano, N., Nose, M., ... Yamano, Y. (2010). [Antimicrobial susceptibility of clinical isolates of aerobic Gram-positive cocci and anaerobic bacteria in 2006]. The Japanese Journal of Antibiotics, 63(6), 431-56.
Yamaguchi T, et al. [Antimicrobial Susceptibility of Clinical Isolates of Aerobic Gram-positive Cocci and Anaerobic Bacteria in 2006]. Jpn J Antibiot. 2010;63(6):431-56. PubMed PMID: 21425596.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Antimicrobial susceptibility of clinical isolates of aerobic Gram-positive cocci and anaerobic bacteria in 2006]. AU - Yamaguchi,Takahiro, AU - Yoshida,Isamu, AU - Itoh,Yoshihisa, AU - Tachibana,Mineji, AU - Takahashi,Choichiro, AU - Kaku,Mitsuo, AU - Kanemitsu,Keiji, AU - Okada,Masahiko, AU - Horikawa,Yoshinori, AU - Shiotani,Joji, AU - Kino,Hiroyoshi, AU - Ono,Yuka, AU - Baba,Hisashi, AU - Matsuo,Shuji, AU - Asari,Seishi, AU - Toyokawa,Masahiro, AU - Matsuoka,Kimiko, AU - Kusano,Nobuchika, AU - Nose,Motoko, AU - Murase,Mitsuharu, AU - Miyamoto,Hitoshi, AU - Saikawa,Tetsunori, AU - Hiramatsu,Kazufumi, AU - Kohno,Shigeru, AU - Yanagihara,Katsunori, AU - Yamane,Nobuhisa, AU - Nakasone,Isamu, AU - Maki,Hideki, AU - Yamano,Yoshinori, PY - 2011/3/24/entrez PY - 2011/3/24/pubmed PY - 2011/5/27/medline SP - 431 EP - 56 JF - The Japanese journal of antibiotics JO - Jpn J Antibiot VL - 63 IS - 6 N2 - The activity of antibacterial agents against aerobic Gram-positive cocci (26 species, 1022 strains) and anaerobic bacteria (23 species, 184 strains) isolated from clinical specimens in 2006 at 16 clinical facilities in Japan were studied using either broth microdilution or agar dilution method. The ratio of methicillin-resistant strains among Staphylococcus aureus and Staphylococcus epidermidis was 53.0% and 65.8%, suggesting that resistant strains were isolated at high frequency. Vancomycin (VCM) and quinupristin/dalfopristin (QPR/DPR) had good antibacterial activity against methicillin-resistant S. aureus and methicillin-resistant S. epidermidis, with MIC90s of < or = 2 micrcog/mL. The ratio of penicillin (PC) intermediate and resistant strains classified by mutations of PC-binding proteins among Streptococcus pneumoniae was 87.6%. Ceftriaxone, cefpirome, cefepime, carbapenem antibiotics, VCM, teicoplanin, linezolid(LZD) and QPR/DPR had MIC90s of < or = 1 microg/mL against PC-intermediate and resistant S. pneumoniae strains. Against all strains of Enterococcus faecalis and Enterococcus faecium, the MICs of VCM and TEIC were under 2 microg/mL, and no resistant strain was detected, suggesting that these agents had excellent activities against these species. 10.9% of E. faecalis strains or 3.5% of E. faecium strains showed intermediate or resistant to LZD. 24.4% of E. faecium strains showed intermediate or resistant to QPR/DPR. Against all strains of Clostridium difficile, the MIC of VCM were under 1 microg/mL, suggesting that VCM had excellent activity against C. difficile. Carbapenems showed good activity against Peptococcaceae, Bacteroides spp., and Prevotella spp. However since several strains of Bacteroides fragilis showed resistant to carbapenems and the susceptibility of this species should be well-focused in the future. SN - 0368-2781 UR - https://www.unboundmedicine.com/medline/citation/21425596/[Antimicrobial_susceptibility_of_clinical_isolates_of_aerobic_Gram_positive_cocci_and_anaerobic_bacteria_in_2006]_ L2 - https://medlineplus.gov/antibiotics.html DB - PRIME DP - Unbound Medicine ER -