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Hip circumference is associated with the risk of premenopausal ER-/PR- breast cancer.

Abstract

OBJECTIVE

We evaluated the relationship between hip and waist circumferences (HCs, WCs), waist-to-hip ratio, height, weight and body mass index (BMI) and breast cancer risk according to menopausal status of women and cancer hormone receptor status.

DESIGN

We used data from the French E3N longitudinal prospective cohort.

SUBJECTS

In the total population of 63 726 women who were analyzed, 1887 breast cancer cases were diagnosed during follow-up.

RESULTS

Among postmenopausal women, the risk of ER+/PR+ breast cancer increased with increasing weight, BMI, and both HCs and WCs, although these two associations disappeared after adjustment for BMI. No association was seen with ER-/PR- breast cancers. Among premenopausal women, among the different factors studied, HC only (no association was observed for any of the different factors studied except for HC) was associated with an increased risk of ER+/PR+ breast cancer after adjustment for BMI (hazard ratio (HR)=1.65; (1.04-2.62) when comparing the highest to lowest tertile; P-trend across tertiles=0.03) and of ER-/PR- breast cancer both before and after adjustment for BMI (HR=2.85 (1.33-6.13); P-trend <0.01, and HR=3.13 (1.19-8.27) P-trend =0.02, respectively). In the latter group, the association with HC was observed whatever the WC (HR=2.81 (1.18-6.70) and HR=2.79 (1.16-6.76) in women with high HC/low WC and high HC/high WC, respectively).

CONCLUSION

The increase in risk of premenopausal breast cancer associated with large HC for both ER+/PR+ and ER-/PR- subtypes may provide insight into a specific risk factor for premenopausal breast cancer.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    INSERM (Institut National de Santé et de Recherche Médicale), Center for Research in Epidemiology and Population Health, Villejuif Cedex, France.

    , , , , ,

    Source

    MeSH

    Adult
    Aged
    Biomarkers, Tumor
    Body Fat Distribution
    Body Mass Index
    Breast Neoplasms
    Cohort Studies
    Female
    France
    Humans
    Longitudinal Studies
    Middle Aged
    Obesity
    Odds Ratio
    Premenopause
    Prospective Studies
    Receptors, Estrogen
    Receptors, Progesterone
    Risk Assessment
    Risk Factors
    Surveys and Questionnaires
    Waist-Hip Ratio

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21427693

    Citation

    Fagherazzi, G, et al. "Hip Circumference Is Associated With the Risk of Premenopausal ER-/PR- Breast Cancer." International Journal of Obesity (2005), vol. 36, no. 3, 2012, pp. 431-9.
    Fagherazzi G, Chabbert-Buffet N, Fabre A, et al. Hip circumference is associated with the risk of premenopausal ER-/PR- breast cancer. Int J Obes (Lond). 2012;36(3):431-9.
    Fagherazzi, G., Chabbert-Buffet, N., Fabre, A., Guillas, G., Boutron-Ruault, M. C., Mesrine, S., & Clavel-Chapelon, F. (2012). Hip circumference is associated with the risk of premenopausal ER-/PR- breast cancer. International Journal of Obesity (2005), 36(3), pp. 431-9. doi:10.1038/ijo.2011.66.
    Fagherazzi G, et al. Hip Circumference Is Associated With the Risk of Premenopausal ER-/PR- Breast Cancer. Int J Obes (Lond). 2012;36(3):431-9. PubMed PMID: 21427693.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Hip circumference is associated with the risk of premenopausal ER-/PR- breast cancer. AU - Fagherazzi,G, AU - Chabbert-Buffet,N, AU - Fabre,A, AU - Guillas,G, AU - Boutron-Ruault,M-C, AU - Mesrine,S, AU - Clavel-Chapelon,F, Y1 - 2011/03/22/ PY - 2011/3/24/entrez PY - 2011/3/24/pubmed PY - 2012/6/20/medline SP - 431 EP - 9 JF - International journal of obesity (2005) JO - Int J Obes (Lond) VL - 36 IS - 3 N2 - OBJECTIVE: We evaluated the relationship between hip and waist circumferences (HCs, WCs), waist-to-hip ratio, height, weight and body mass index (BMI) and breast cancer risk according to menopausal status of women and cancer hormone receptor status. DESIGN: We used data from the French E3N longitudinal prospective cohort. SUBJECTS: In the total population of 63 726 women who were analyzed, 1887 breast cancer cases were diagnosed during follow-up. RESULTS: Among postmenopausal women, the risk of ER+/PR+ breast cancer increased with increasing weight, BMI, and both HCs and WCs, although these two associations disappeared after adjustment for BMI. No association was seen with ER-/PR- breast cancers. Among premenopausal women, among the different factors studied, HC only (no association was observed for any of the different factors studied except for HC) was associated with an increased risk of ER+/PR+ breast cancer after adjustment for BMI (hazard ratio (HR)=1.65; (1.04-2.62) when comparing the highest to lowest tertile; P-trend across tertiles=0.03) and of ER-/PR- breast cancer both before and after adjustment for BMI (HR=2.85 (1.33-6.13); P-trend <0.01, and HR=3.13 (1.19-8.27) P-trend =0.02, respectively). In the latter group, the association with HC was observed whatever the WC (HR=2.81 (1.18-6.70) and HR=2.79 (1.16-6.76) in women with high HC/low WC and high HC/high WC, respectively). CONCLUSION: The increase in risk of premenopausal breast cancer associated with large HC for both ER+/PR+ and ER-/PR- subtypes may provide insight into a specific risk factor for premenopausal breast cancer. SN - 1476-5497 UR - https://www.unboundmedicine.com/medline/citation/21427693/Hip_circumference_is_associated_with_the_risk_of_premenopausal_ER_/PR__breast_cancer_ L2 - http://dx.doi.org/10.1038/ijo.2011.66 DB - PRIME DP - Unbound Medicine ER -