Tags

Type your tag names separated by a space and hit enter

Associations of obesity with triglycerides and C-reactive protein are attenuated in adults with high red blood cell eicosapentaenoic and docosahexaenoic acids.
Eur J Clin Nutr. 2011 Jul; 65(7):808-17.EJ

Abstract

BACKGROUND

N-3 fatty acids are associated with favorable, and obesity with unfavorable, concentrations of chronic disease risk biomarkers.

OBJECTIVE

We examined whether high eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid intakes, measured as percentages of total red blood cell (RBC) fatty acids, modify associations of obesity with chronic disease risk biomarkers.

METHODS

In a cross-sectional study of 330 Yup'ik Eskimos, generalized additive models (GAM) and linear and quadratic regression models were used to examine associations of BMI with biomarkers across RBC EPA and DHA categories.

RESULTS

Median (5th-95th percentile) RBC EPA and DHA were 2.6% (0.5-5.9%) and 7.3% (3.3-8.9%), respectively. In regression models, associations of BMI with triglycerides, glucose, insulin, C-reactive protein (CRP) and leptin differed significantly by RBC EPA and DHA. The GAM confirmed regression results for triglycerides and CRP: at low RBC EPA and RBC DHA, the predicted increases in triglycerides and CRP concentrations associated with a BMI increase from 25 to 35 were 99.5±45.3 mg/dl (106%) and 137.8±71.0 mg/dl (156%), respectively, for triglycerides and 1.2±0.7 mg/l (61%) and 0.8±1.0 mg/l (35%), respectively, for CRP. At high RBC EPA and RBC DHA, these predicted increases were 13.9±8.1 mg/dl (23%) and 12.0±12.3 mg/dl (18%), respectively, for triglycerides and 0.5±0.5 mg/l (50%) and -0.5±0.6 mg/l (-34%), respectively, for CRP.

CONCLUSIONS

In this population, high RBC EPA and DHA were associated with attenuated dyslipidemia and low-grade systemic inflammation among overweight and obese persons. This may help inform recommendations for n-3 fatty acid intakes in the reduction of obesity-related disease risk.

Authors+Show Affiliations

Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA. zmakhoul@fhcrc.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

21427737

Citation

Makhoul, Z, et al. "Associations of Obesity With Triglycerides and C-reactive Protein Are Attenuated in Adults With High Red Blood Cell Eicosapentaenoic and Docosahexaenoic Acids." European Journal of Clinical Nutrition, vol. 65, no. 7, 2011, pp. 808-17.
Makhoul Z, Kristal AR, Gulati R, et al. Associations of obesity with triglycerides and C-reactive protein are attenuated in adults with high red blood cell eicosapentaenoic and docosahexaenoic acids. Eur J Clin Nutr. 2011;65(7):808-17.
Makhoul, Z., Kristal, A. R., Gulati, R., Luick, B., Bersamin, A., O'Brien, D., Hopkins, S. E., Stephensen, C. B., Stanhope, K. L., Havel, P. J., & Boyer, B. (2011). Associations of obesity with triglycerides and C-reactive protein are attenuated in adults with high red blood cell eicosapentaenoic and docosahexaenoic acids. European Journal of Clinical Nutrition, 65(7), 808-17. https://doi.org/10.1038/ejcn.2011.39
Makhoul Z, et al. Associations of Obesity With Triglycerides and C-reactive Protein Are Attenuated in Adults With High Red Blood Cell Eicosapentaenoic and Docosahexaenoic Acids. Eur J Clin Nutr. 2011;65(7):808-17. PubMed PMID: 21427737.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations of obesity with triglycerides and C-reactive protein are attenuated in adults with high red blood cell eicosapentaenoic and docosahexaenoic acids. AU - Makhoul,Z, AU - Kristal,A R, AU - Gulati,R, AU - Luick,B, AU - Bersamin,A, AU - O'Brien,D, AU - Hopkins,S E, AU - Stephensen,C B, AU - Stanhope,K L, AU - Havel,P J, AU - Boyer,B, Y1 - 2011/03/23/ PY - 2011/3/24/entrez PY - 2011/3/24/pubmed PY - 2011/11/10/medline SP - 808 EP - 17 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 65 IS - 7 N2 - BACKGROUND: N-3 fatty acids are associated with favorable, and obesity with unfavorable, concentrations of chronic disease risk biomarkers. OBJECTIVE: We examined whether high eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid intakes, measured as percentages of total red blood cell (RBC) fatty acids, modify associations of obesity with chronic disease risk biomarkers. METHODS: In a cross-sectional study of 330 Yup'ik Eskimos, generalized additive models (GAM) and linear and quadratic regression models were used to examine associations of BMI with biomarkers across RBC EPA and DHA categories. RESULTS: Median (5th-95th percentile) RBC EPA and DHA were 2.6% (0.5-5.9%) and 7.3% (3.3-8.9%), respectively. In regression models, associations of BMI with triglycerides, glucose, insulin, C-reactive protein (CRP) and leptin differed significantly by RBC EPA and DHA. The GAM confirmed regression results for triglycerides and CRP: at low RBC EPA and RBC DHA, the predicted increases in triglycerides and CRP concentrations associated with a BMI increase from 25 to 35 were 99.5±45.3 mg/dl (106%) and 137.8±71.0 mg/dl (156%), respectively, for triglycerides and 1.2±0.7 mg/l (61%) and 0.8±1.0 mg/l (35%), respectively, for CRP. At high RBC EPA and RBC DHA, these predicted increases were 13.9±8.1 mg/dl (23%) and 12.0±12.3 mg/dl (18%), respectively, for triglycerides and 0.5±0.5 mg/l (50%) and -0.5±0.6 mg/l (-34%), respectively, for CRP. CONCLUSIONS: In this population, high RBC EPA and DHA were associated with attenuated dyslipidemia and low-grade systemic inflammation among overweight and obese persons. This may help inform recommendations for n-3 fatty acid intakes in the reduction of obesity-related disease risk. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/21427737/Associations_of_obesity_with_triglycerides_and_C_reactive_protein_are_attenuated_in_adults_with_high_red_blood_cell_eicosapentaenoic_and_docosahexaenoic_acids_ L2 - https://doi.org/10.1038/ejcn.2011.39 DB - PRIME DP - Unbound Medicine ER -