Tags

Type your tag names separated by a space and hit enter

Lipid redistribution by α-linolenic acid-rich chia seed inhibits stearoyl-CoA desaturase-1 and induces cardiac and hepatic protection in diet-induced obese rats.
J Nutr Biochem. 2012 Feb; 23(2):153-62.JN

Abstract

Chia seeds contain the essential fatty acid, α-linolenic acid (ALA). This study has assessed whether chia seeds attenuated the metabolic, cardiovascular and hepatic signs of a high-carbohydrate, high-fat (H) diet [carbohydrates, 52% (wt/wt); fat, 24% (wt/wt) with 25% (wt/vol) fructose in drinking water] in rats. Diets of the treatment groups were supplemented with 5% chia seeds after 8 weeks on H diet for a further 8 weeks. Compared with the H rats, chia seed-supplemented rats had improved insulin sensitivity and glucose tolerance, reduced visceral adiposity, decreased hepatic steatosis and reduced cardiac and hepatic inflammation and fibrosis without changes in plasma lipids or blood pressure. Chia seeds induced lipid redistribution with lipid trafficking away from the visceral fat and liver with an increased accumulation in the heart. The stearoyl-CoA desaturase-1 products were depleted in the heart, liver and the adipose tissue of chia seed-supplemented rats together with an increase in the substrate concentrations. The C18:1trans-7 was preferentially stored in the adipose tissue; the relatively inert C18:1n-9 was stored in sensitive organs such as liver and heart and C18:2n-6, the parent fatty acid of the n-6 pathway, was preferentially metabolized. Thus, chia seeds as a source of ALA induce lipid redistribution associated with cardioprotection and hepatoprotection.

Authors+Show Affiliations

School of Biomedical Sciences, The University of Queensland, Brisbane 4072, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21429727

Citation

Poudyal, Hemant, et al. "Lipid Redistribution By Α-linolenic Acid-rich Chia Seed Inhibits stearoyl-CoA Desaturase-1 and Induces Cardiac and Hepatic Protection in Diet-induced Obese Rats." The Journal of Nutritional Biochemistry, vol. 23, no. 2, 2012, pp. 153-62.
Poudyal H, Panchal SK, Waanders J, et al. Lipid redistribution by α-linolenic acid-rich chia seed inhibits stearoyl-CoA desaturase-1 and induces cardiac and hepatic protection in diet-induced obese rats. J Nutr Biochem. 2012;23(2):153-62.
Poudyal, H., Panchal, S. K., Waanders, J., Ward, L., & Brown, L. (2012). Lipid redistribution by α-linolenic acid-rich chia seed inhibits stearoyl-CoA desaturase-1 and induces cardiac and hepatic protection in diet-induced obese rats. The Journal of Nutritional Biochemistry, 23(2), 153-62. https://doi.org/10.1016/j.jnutbio.2010.11.011
Poudyal H, et al. Lipid Redistribution By Α-linolenic Acid-rich Chia Seed Inhibits stearoyl-CoA Desaturase-1 and Induces Cardiac and Hepatic Protection in Diet-induced Obese Rats. J Nutr Biochem. 2012;23(2):153-62. PubMed PMID: 21429727.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipid redistribution by α-linolenic acid-rich chia seed inhibits stearoyl-CoA desaturase-1 and induces cardiac and hepatic protection in diet-induced obese rats. AU - Poudyal,Hemant, AU - Panchal,Sunil K, AU - Waanders,Jennifer, AU - Ward,Leigh, AU - Brown,Lindsay, Y1 - 2011/03/22/ PY - 2010/09/05/received PY - 2010/10/30/revised PY - 2010/11/09/accepted PY - 2011/3/25/entrez PY - 2011/3/25/pubmed PY - 2012/5/17/medline SP - 153 EP - 62 JF - The Journal of nutritional biochemistry JO - J Nutr Biochem VL - 23 IS - 2 N2 - Chia seeds contain the essential fatty acid, α-linolenic acid (ALA). This study has assessed whether chia seeds attenuated the metabolic, cardiovascular and hepatic signs of a high-carbohydrate, high-fat (H) diet [carbohydrates, 52% (wt/wt); fat, 24% (wt/wt) with 25% (wt/vol) fructose in drinking water] in rats. Diets of the treatment groups were supplemented with 5% chia seeds after 8 weeks on H diet for a further 8 weeks. Compared with the H rats, chia seed-supplemented rats had improved insulin sensitivity and glucose tolerance, reduced visceral adiposity, decreased hepatic steatosis and reduced cardiac and hepatic inflammation and fibrosis without changes in plasma lipids or blood pressure. Chia seeds induced lipid redistribution with lipid trafficking away from the visceral fat and liver with an increased accumulation in the heart. The stearoyl-CoA desaturase-1 products were depleted in the heart, liver and the adipose tissue of chia seed-supplemented rats together with an increase in the substrate concentrations. The C18:1trans-7 was preferentially stored in the adipose tissue; the relatively inert C18:1n-9 was stored in sensitive organs such as liver and heart and C18:2n-6, the parent fatty acid of the n-6 pathway, was preferentially metabolized. Thus, chia seeds as a source of ALA induce lipid redistribution associated with cardioprotection and hepatoprotection. SN - 1873-4847 UR - https://www.unboundmedicine.com/medline/citation/21429727/Lipid_redistribution_by_α_linolenic_acid_rich_chia_seed_inhibits_stearoyl_CoA_desaturase_1_and_induces_cardiac_and_hepatic_protection_in_diet_induced_obese_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0955-2863(11)00008-8 DB - PRIME DP - Unbound Medicine ER -