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TGF-B1 pathway as biological marker of bladder carcinoma schistosomal and non-schistosomal.
Urol Oncol. 2013 Apr; 31(3):372-8.UO

Abstract

OBJECTIVES

Study TGF-β1 pathway in bladder carcinoma.

DESIGN AND METHODS

Eighty-one patients were enrolled: 16 chronic cystitis and 60 malignant bladder lesions; 15 schistosomal squamous cell carcinoma (SQCC), 45 transitional cell carcinoma (TCC). Five healthy individuals served as controls. mTGF-β1, protein, and its receptor expression in urine and bladder tissue were measured using in situ hybridization and immunohistochemical techniques, respectively.

RESULTS

Overexpression of TGF-mRNA in invasive TCC group was compared with superficial TCC, high grade TCC was compared with low grade, and SQCC was compared with TCC. TGF-β1 protein and its receptor I (TGF-βR1) were overexpressed in urine samples in malignant group compared with chronic cystitis and in SQCC group compared with TCC group. TGF-β1 protein and its receptor were significantly increased in schistosomal malignant group compared with non-schistosomal group.

CONCLUSION

Expression of TGF-β1 and TGF-βR1 could be used as biological markers of bladder carcinoma.

Authors+Show Affiliations

Department of Medical Biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt. olfatshaker@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21429769

Citation

Shaker, Olfat, et al. "TGF-B1 Pathway as Biological Marker of Bladder Carcinoma Schistosomal and Non-schistosomal." Urologic Oncology, vol. 31, no. 3, 2013, pp. 372-8.
Shaker O, Hammam O, Wishahi M, et al. TGF-B1 pathway as biological marker of bladder carcinoma schistosomal and non-schistosomal. Urol Oncol. 2013;31(3):372-8.
Shaker, O., Hammam, O., Wishahi, M., & Roshdi, M. (2013). TGF-B1 pathway as biological marker of bladder carcinoma schistosomal and non-schistosomal. Urologic Oncology, 31(3), 372-8. https://doi.org/10.1016/j.urolonc.2011.02.003
Shaker O, et al. TGF-B1 Pathway as Biological Marker of Bladder Carcinoma Schistosomal and Non-schistosomal. Urol Oncol. 2013;31(3):372-8. PubMed PMID: 21429769.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - TGF-B1 pathway as biological marker of bladder carcinoma schistosomal and non-schistosomal. AU - Shaker,Olfat, AU - Hammam,Olfat, AU - Wishahi,Mohamed, AU - Roshdi,Mamdouh, Y1 - 2011/03/23/ PY - 2010/10/01/received PY - 2011/02/06/revised PY - 2011/02/07/accepted PY - 2011/3/25/entrez PY - 2011/3/25/pubmed PY - 2013/9/17/medline SP - 372 EP - 8 JF - Urologic oncology JO - Urol. Oncol. VL - 31 IS - 3 N2 - OBJECTIVES: Study TGF-β1 pathway in bladder carcinoma. DESIGN AND METHODS: Eighty-one patients were enrolled: 16 chronic cystitis and 60 malignant bladder lesions; 15 schistosomal squamous cell carcinoma (SQCC), 45 transitional cell carcinoma (TCC). Five healthy individuals served as controls. mTGF-β1, protein, and its receptor expression in urine and bladder tissue were measured using in situ hybridization and immunohistochemical techniques, respectively. RESULTS: Overexpression of TGF-mRNA in invasive TCC group was compared with superficial TCC, high grade TCC was compared with low grade, and SQCC was compared with TCC. TGF-β1 protein and its receptor I (TGF-βR1) were overexpressed in urine samples in malignant group compared with chronic cystitis and in SQCC group compared with TCC group. TGF-β1 protein and its receptor were significantly increased in schistosomal malignant group compared with non-schistosomal group. CONCLUSION: Expression of TGF-β1 and TGF-βR1 could be used as biological markers of bladder carcinoma. SN - 1873-2496 UR - https://www.unboundmedicine.com/medline/citation/21429769/TGF_B1_pathway_as_biological_marker_of_bladder_carcinoma_schistosomal_and_non_schistosomal_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1078-1439(11)00047-0 DB - PRIME DP - Unbound Medicine ER -