Tags

Type your tag names separated by a space and hit enter

Maternal smoking during pregnancy and offspring attention-deficit/hyperactivity disorder: a case-control study in Japan.
Atten Defic Hyperact Disord. 2009 Dec; 1(2):223-31.AD

Abstract

Although maternal smoking during pregnancy has been shown to be associated with an increased risk of offspring attention-deficit/hyperactivity disorder (ADHD) in Western countries, there is no empirical evidence in non-Caucasian. Purpose of the present study is to examine the relationship between maternal smoking during pregnancy and offspring ADHD in Japanese population. A case-control study design was adopted. A total of 90 pairs of children with ADHD and mothers as well as 270 corresponding control pairs were recruited throughout the study period. A psychiatrist interviewed all the mothers of children with ADHD and control children and elicited information regarding their lifestyles during pregnancy, including active and passive smoking or drinking habits, as well as psychosocial and perinatal factors. Diagnosis of ADHD was made by each physician in charge according to DSM-IV diagnostic criteria. Logistic regression analysis was used to calculate odds ratios (OR) and 95% confidence intervals (CI) with adjustments for other possible confounding factors. Maternal active smoking during pregnancy was associated with an approximately twofold increased risk of offspring ADHD, even after adjusting for socioeconomic and perinatal confounding factors (OR 1.8 95% CI 0.9-3.6). However, the association was obviously attenuated when factors regarding parental psychopathological vulnerability were controlled (OR 1.3 95% CI 0.6-2.9). On the other hand, maternal passive smoking during pregnancy failed to show any material association with ADHD. These results suggested that a significant part of the association between maternal smoking during pregnancy, and ADHD might be explained by genetic factors including parental psychopathological vulnerability.

Authors+Show Affiliations

Department of Hygiene, School of Medicine, Wakayama Medical University, 8-1-1 Kimiidera, Wakayama 641-0012, Japan. kyoshi@wakayama-med.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21432585

Citation

Yoshimasu, Kouichi, et al. "Maternal Smoking During Pregnancy and Offspring Attention-deficit/hyperactivity Disorder: a Case-control Study in Japan." Attention Deficit and Hyperactivity Disorders, vol. 1, no. 2, 2009, pp. 223-31.
Yoshimasu K, Kiyohara C, Minami T, et al. Maternal smoking during pregnancy and offspring attention-deficit/hyperactivity disorder: a case-control study in Japan. Atten Defic Hyperact Disord. 2009;1(2):223-31.
Yoshimasu, K., Kiyohara, C., Minami, T., Yoshikawa, N., Kihira, S., Toyonaga, K., Yamamoto, A., Shinosaki, K., Yamashita, H., & Miyashita, K. (2009). Maternal smoking during pregnancy and offspring attention-deficit/hyperactivity disorder: a case-control study in Japan. Attention Deficit and Hyperactivity Disorders, 1(2), 223-31. https://doi.org/10.1007/s12402-009-0015-1
Yoshimasu K, et al. Maternal Smoking During Pregnancy and Offspring Attention-deficit/hyperactivity Disorder: a Case-control Study in Japan. Atten Defic Hyperact Disord. 2009;1(2):223-31. PubMed PMID: 21432585.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal smoking during pregnancy and offspring attention-deficit/hyperactivity disorder: a case-control study in Japan. AU - Yoshimasu,Kouichi, AU - Kiyohara,Chikako, AU - Minami,Takaomi, AU - Yoshikawa,Norishige, AU - Kihira,Shogo, AU - Toyonaga,Koji, AU - Yamamoto,Akira, AU - Shinosaki,Kazuhiro, AU - Yamashita,Hiroshi, AU - Miyashita,Kazuhisa, AU - ,, Y1 - 2009/11/12/ PY - 2009/09/25/received PY - 2009/10/22/accepted PY - 2011/3/25/entrez PY - 2009/12/1/pubmed PY - 2011/7/27/medline SP - 223 EP - 31 JF - Attention deficit and hyperactivity disorders JO - Atten Defic Hyperact Disord VL - 1 IS - 2 N2 - Although maternal smoking during pregnancy has been shown to be associated with an increased risk of offspring attention-deficit/hyperactivity disorder (ADHD) in Western countries, there is no empirical evidence in non-Caucasian. Purpose of the present study is to examine the relationship between maternal smoking during pregnancy and offspring ADHD in Japanese population. A case-control study design was adopted. A total of 90 pairs of children with ADHD and mothers as well as 270 corresponding control pairs were recruited throughout the study period. A psychiatrist interviewed all the mothers of children with ADHD and control children and elicited information regarding their lifestyles during pregnancy, including active and passive smoking or drinking habits, as well as psychosocial and perinatal factors. Diagnosis of ADHD was made by each physician in charge according to DSM-IV diagnostic criteria. Logistic regression analysis was used to calculate odds ratios (OR) and 95% confidence intervals (CI) with adjustments for other possible confounding factors. Maternal active smoking during pregnancy was associated with an approximately twofold increased risk of offspring ADHD, even after adjusting for socioeconomic and perinatal confounding factors (OR 1.8 95% CI 0.9-3.6). However, the association was obviously attenuated when factors regarding parental psychopathological vulnerability were controlled (OR 1.3 95% CI 0.6-2.9). On the other hand, maternal passive smoking during pregnancy failed to show any material association with ADHD. These results suggested that a significant part of the association between maternal smoking during pregnancy, and ADHD might be explained by genetic factors including parental psychopathological vulnerability. SN - 1866-6647 UR - https://www.unboundmedicine.com/medline/citation/21432585/Maternal_smoking_during_pregnancy_and_offspring_attention_deficit/hyperactivity_disorder:_a_case_control_study_in_Japan_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=21432585.ui DB - PRIME DP - Unbound Medicine ER -