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Toward a better understanding of ADHD: LPHN3 gene variants and the susceptibility to develop ADHD.
Atten Defic Hyperact Disord 2010; 2(3):139-47AD

Abstract

During the past 15 years, an impressive amount of genetic information has become available in the research field of psychiatry, particularly as it relates to attention-deficit/hyperactivity disorder (ADHD). However, the classical clinical approach to ADHD has minimally affected and not significantly been improved by this genetic revolution. It is difficult to predict how long it will take for genetic findings to alter the way clinicians treat patients with ADHD. New medications or treatment protocols may take years to become routine clinical practice. However, when taken together, recent successes in genomics, pharmacogenomics, and genetic epidemiology have the potential (1) to prevent comorbid consequences of ADHD, (2) to individualize therapies for patients with ADHD, and (3) to define new epidemiological policies to aid with the impact of ADHD on society. Here, we present an overview of how genetic research may affect and improve the quality of life of patients with ADHD: as an example, we use the discovery of LPHN3, a new gene in which variants have recently been shown to be associated with ADHD.

Authors+Show Affiliations

National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural
Review

Language

eng

PubMed ID

21432600

Citation

Arcos-Burgos, Mauricio, and Maximilian Muenke. "Toward a Better Understanding of ADHD: LPHN3 Gene Variants and the Susceptibility to Develop ADHD." Attention Deficit and Hyperactivity Disorders, vol. 2, no. 3, 2010, pp. 139-47.
Arcos-Burgos M, Muenke M. Toward a better understanding of ADHD: LPHN3 gene variants and the susceptibility to develop ADHD. Atten Defic Hyperact Disord. 2010;2(3):139-47.
Arcos-Burgos, M., & Muenke, M. (2010). Toward a better understanding of ADHD: LPHN3 gene variants and the susceptibility to develop ADHD. Attention Deficit and Hyperactivity Disorders, 2(3), pp. 139-47. doi:10.1007/s12402-010-0030-2.
Arcos-Burgos M, Muenke M. Toward a Better Understanding of ADHD: LPHN3 Gene Variants and the Susceptibility to Develop ADHD. Atten Defic Hyperact Disord. 2010;2(3):139-47. PubMed PMID: 21432600.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Toward a better understanding of ADHD: LPHN3 gene variants and the susceptibility to develop ADHD. AU - Arcos-Burgos,Mauricio, AU - Muenke,Maximilian, Y1 - 2010/10/16/ PY - 2010/04/07/received PY - 2010/07/29/accepted PY - 2011/3/25/entrez PY - 2011/3/25/pubmed PY - 2011/7/27/medline SP - 139 EP - 47 JF - Attention deficit and hyperactivity disorders JO - Atten Defic Hyperact Disord VL - 2 IS - 3 N2 - During the past 15 years, an impressive amount of genetic information has become available in the research field of psychiatry, particularly as it relates to attention-deficit/hyperactivity disorder (ADHD). However, the classical clinical approach to ADHD has minimally affected and not significantly been improved by this genetic revolution. It is difficult to predict how long it will take for genetic findings to alter the way clinicians treat patients with ADHD. New medications or treatment protocols may take years to become routine clinical practice. However, when taken together, recent successes in genomics, pharmacogenomics, and genetic epidemiology have the potential (1) to prevent comorbid consequences of ADHD, (2) to individualize therapies for patients with ADHD, and (3) to define new epidemiological policies to aid with the impact of ADHD on society. Here, we present an overview of how genetic research may affect and improve the quality of life of patients with ADHD: as an example, we use the discovery of LPHN3, a new gene in which variants have recently been shown to be associated with ADHD. SN - 1866-6647 UR - https://www.unboundmedicine.com/medline/citation/21432600/Toward_a_better_understanding_of_ADHD:_LPHN3_gene_variants_and_the_susceptibility_to_develop_ADHD_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=21432600.ui DB - PRIME DP - Unbound Medicine ER -