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Complement 3 and factor h in human cerebrospinal fluid in Parkinson's disease, Alzheimer's disease, and multiple-system atrophy.

Abstract

Complement activation, a key component of neuroinflammation, has been reported in both Parkinson's disease (PD) and Alzheimer's disease (AD). However, it is unclear whether complement activation and neuroinflammation in general are distinctly different from each another in major neurodegenerative disorders. In the present study, cerebrospinal fluid complement 3 (C3) and factor H (FH) were measured and evaluated together with amyloid-β(42) (Aβ(42)), which in recent investigations was decreased in patients with PD, in particular those with cognitive impairment. The study included 345 participants: 126 patients with PD at various stages with or without cognitive impairment, 50 with AD, and 32 with multiple-system atrophy, and 137 healthy control individuals. In addition to changes in Aβ(42) concentrations, there were clear differences in the patterns of complement profiles among neurodegenerative disorders. The C3/FH ratio demonstrated high sensitivity and specificity in differentiating patients with multiple-system atrophy from those with AD or PD and control individuals. In addition, the C3/Aβ(42) and FH/Aβ(42) ratios not only correlated with PD severity approximated using the Unified Parkinson's Disease Rating Scale but also with the presence of cognitive impairment or dementia in PD. Both C3 and FH correlated with the severity of impairment in AD as indicated using Mini-Mental State Examination scores.

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    Source

    The American journal of pathology 178:4 2011 Apr pg 1509-16

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Alzheimer Disease
    Amyloid beta-Peptides
    Case-Control Studies
    Cohort Studies
    Complement C3
    Complement Factor H
    Female
    Humans
    Inflammation
    Male
    Middle Aged
    Multiple System Atrophy
    Parkinson Disease
    Peptide Fragments
    Quality Control
    Regression Analysis

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    21435440