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Molecular findings in childhood leukemia in Brazil: high frequency of MLL-ENL Fusion/t(11;19) in infant leukemia.
J Pediatr Hematol Oncol. 2011 Aug; 33(6):470-4.JP

Abstract

Translocations involving chromosome 11q23 are frequently found in pediatric leukemia, especially in infants. The mixed lineage leukemia (MLL)-AF4 fusion/t(4;11) is mostly found in acute lymphoblastic leukemia (ALL) and MLL-AF9 fusion/t(9;11) in acute myeloid leukemia (AML). We study 441 consecutive new cases of childhood leukemia diagnosed in Brazil. Chromosomal translocation was determined solely by conventional polymerase chain reaction (PCR) in 72 out of 265 ALL and in 43 out of 103 AML. MLL-AF4 fusion/t(4;11) was detected in 3 out of 265 ALL and MLL-AF9 fusion/t(9;11) in 4 out of 103 of AML. MLL-rearrangements were presented in 7 out of 23 infant leukemia, whose 5 were MLL-ENL fusion/t(11;19). No fusion MLL-AF4 fusion/t(4;11) was found. Other translocation frequencies differed from that reported for an American population suggesting interethnic differences on chromosomal translocations frequencies in acute leukemia.

Authors+Show Affiliations

Pediatric Oncology Service/IMIP Hospital, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21436736

Citation

Marques, Ester Augusta Lima Vinhas, et al. "Molecular Findings in Childhood Leukemia in Brazil: High Frequency of MLL-ENL Fusion/t(11;19) in Infant Leukemia." Journal of Pediatric Hematology/oncology, vol. 33, no. 6, 2011, pp. 470-4.
Marques EA, Neves L, Fonseca TC, et al. Molecular findings in childhood leukemia in Brazil: high frequency of MLL-ENL Fusion/t(11;19) in infant leukemia. J Pediatr Hematol Oncol. 2011;33(6):470-4.
Marques, E. A., Neves, L., Fonseca, T. C., Lins, M. M., Pedrosa, F., & Lucena-Silva, N. (2011). Molecular findings in childhood leukemia in Brazil: high frequency of MLL-ENL Fusion/t(11;19) in infant leukemia. Journal of Pediatric Hematology/oncology, 33(6), 470-4. https://doi.org/10.1097/MPH.0b013e3181fb8f61
Marques EA, et al. Molecular Findings in Childhood Leukemia in Brazil: High Frequency of MLL-ENL Fusion/t(11;19) in Infant Leukemia. J Pediatr Hematol Oncol. 2011;33(6):470-4. PubMed PMID: 21436736.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular findings in childhood leukemia in Brazil: high frequency of MLL-ENL Fusion/t(11;19) in infant leukemia. AU - Marques,Ester Augusta Lima Vinhas, AU - Neves,Lidia, AU - Fonseca,Tereza Cristina, AU - Lins,Mecneide Mendes, AU - Pedrosa,Francisco, AU - Lucena-Silva,Norma, PY - 2011/3/26/entrez PY - 2011/3/26/pubmed PY - 2011/9/29/medline SP - 470 EP - 4 JF - Journal of pediatric hematology/oncology JO - J Pediatr Hematol Oncol VL - 33 IS - 6 N2 - Translocations involving chromosome 11q23 are frequently found in pediatric leukemia, especially in infants. The mixed lineage leukemia (MLL)-AF4 fusion/t(4;11) is mostly found in acute lymphoblastic leukemia (ALL) and MLL-AF9 fusion/t(9;11) in acute myeloid leukemia (AML). We study 441 consecutive new cases of childhood leukemia diagnosed in Brazil. Chromosomal translocation was determined solely by conventional polymerase chain reaction (PCR) in 72 out of 265 ALL and in 43 out of 103 AML. MLL-AF4 fusion/t(4;11) was detected in 3 out of 265 ALL and MLL-AF9 fusion/t(9;11) in 4 out of 103 of AML. MLL-rearrangements were presented in 7 out of 23 infant leukemia, whose 5 were MLL-ENL fusion/t(11;19). No fusion MLL-AF4 fusion/t(4;11) was found. Other translocation frequencies differed from that reported for an American population suggesting interethnic differences on chromosomal translocations frequencies in acute leukemia. SN - 1536-3678 UR - https://www.unboundmedicine.com/medline/citation/21436736/Molecular_findings_in_childhood_leukemia_in_Brazil:_high_frequency_of_MLL_ENL_Fusion/t_11 L2 - https://doi.org/10.1097/MPH.0b013e3181fb8f61 DB - PRIME DP - Unbound Medicine ER -