TY - JOUR T1 - Leukotriene receptor antagonists in monotherapy or in combination with antihistamines in the treatment of chronic urticaria: a systematic review. AU - Di Lorenzo,Gabriele, AU - D'Alcamo,Alberto, AU - Rizzo,Manfredi, AU - Leto-Barone,Maria Stefania, AU - Bianco,Claudia Lo, AU - Ditta,Vito, AU - Politi,Donatella, AU - Castello,Francesco, AU - Pepe,Ilenia, AU - Di Fede,Gaetana, AU - Rini,Giovambattista, Y1 - 2008/12/09/ PY - 2011/3/26/entrez PY - 2008/1/1/pubmed PY - 2008/1/1/medline KW - antihistamine KW - chronic idiopathic urticaria KW - leukotriene receptor antagonists KW - montelukast KW - zafirlukast SP - 9 EP - 16 JF - Journal of asthma and allergy JO - J Asthma Allergy VL - 2 N2 - In vitro and in vivo clinical and experimental data have suggested that leukotrienes play a key role in inflammatory reactions of the skin. Antileukotriene drugs, ie, leukotriene receptor antagonists and synthesis inhibitors, are a class of anti-inflammatory drugs that have shown clinical efficacy in the management of asthma and in rhinitis with asthma. We searched MEDLINE database and carried out a manual search on journals specializing in allergy and dermatology for the use of antileukotriene drugs in urticaria. Montelukast might be effective in chronic urticaria associated with aspirin (ASA) or food additive hypersensitivity or with autoreactivity to intradermal serum injection (ASST) when taken with an antihistamine but not in mild or moderate chronic idiopathic urticaria [urticaria without any possible secondary causes (ie, food additive or ASA and other NSAID hypersensitivity, or ASST)]. Evidence for the effectiveness of zafirlukast and the 5-lipoxygenase inhibitor, zileuton, in chronic urticaria is mainly anecdotal. In addition, there is anecdotal evidence of effectiveness of antileukotrienes in primary cold urticaria, delayed pressure urticaria and dermographism. No evidence exists for other physical urticarias, including cholinergic, solar and aquagenic urticarias, vibratory angioedema, and exercise-induced anaphylaxis. SN - 1178-6965 UR - https://www.unboundmedicine.com/medline/citation/21437139/Leukotriene_receptor_antagonists_in_monotherapy_or_in_combination_with_antihistamines_in_the_treatment_of_chronic_urticaria:_a_systematic_review_ L2 - https://dx.doi.org/10.2147/jaa.s3236 DB - PRIME DP - Unbound Medicine ER -