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High-risk human papillomavirus and cervical lymph node metastasis in patients with oropharyngeal cancer.
Head Neck. 2012 Jan; 34(1):10-4.HN

Abstract

BACKGROUND

The purpose of this study was to determine the role of high-risk human papillomavirus (HPV) in lymph node metastasis and the depth of invasion in oropharyngeal cancer.

METHODS

The study included patients with 90 oral carcinomas and 66 oropharyngeal carcinomas. High-risk HPV in situ hybridization was performed to detect HPV infection.

RESULTS

The positive rate of high-risk HPV in situ hybridization was 15.4% (24 of 156). There was a significant difference in the fraction of positive high-risk HPV between oral (6.7%) and oropharyngeal (27.3%) cancers (p < .000). Significant correlations were found between positive high-risk HPV and cervical lymph node metastasis, tumor depth of invasion in patients with oropharyngeal cancer (p = .002, p = .016, respectively). There was a statistically significant association between high-risk HPV positivity and the disease-specific survival in patients with oropharyngeal cancer (p = .035).

CONCLUSION

High-risk HPV infection was significantly related to cervical lymph node metastasis and depth of invasion in patients with oropharyngeal cancer. © 2011 Wiley Periodicals, Inc. Head Neck, 2012.

Authors+Show Affiliations

Department of Otolaryngology-Head and Neck Surgery, College of Medicine, St. Mary's Hospital, The Catholic University of Korea, Seoul.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21438064

Citation

Joo, Young-Hoon, et al. "High-risk Human Papillomavirus and Cervical Lymph Node Metastasis in Patients With Oropharyngeal Cancer." Head & Neck, vol. 34, no. 1, 2012, pp. 10-4.
Joo YH, Jung CK, Sun DI, et al. High-risk human papillomavirus and cervical lymph node metastasis in patients with oropharyngeal cancer. Head Neck. 2012;34(1):10-4.
Joo, Y. H., Jung, C. K., Sun, D. I., Park, J. O., Cho, K. J., & Kim, M. S. (2012). High-risk human papillomavirus and cervical lymph node metastasis in patients with oropharyngeal cancer. Head & Neck, 34(1), 10-4. https://doi.org/10.1002/hed.21697
Joo YH, et al. High-risk Human Papillomavirus and Cervical Lymph Node Metastasis in Patients With Oropharyngeal Cancer. Head Neck. 2012;34(1):10-4. PubMed PMID: 21438064.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-risk human papillomavirus and cervical lymph node metastasis in patients with oropharyngeal cancer. AU - Joo,Young-Hoon, AU - Jung,Chan-Kwon, AU - Sun,Dong-Il, AU - Park,Jun-Ook, AU - Cho,Kwang-Jae, AU - Kim,Min-Sik, Y1 - 2011/03/24/ PY - 2010/10/22/accepted PY - 2011/3/26/entrez PY - 2011/3/26/pubmed PY - 2012/10/24/medline SP - 10 EP - 4 JF - Head & neck JO - Head Neck VL - 34 IS - 1 N2 - BACKGROUND: The purpose of this study was to determine the role of high-risk human papillomavirus (HPV) in lymph node metastasis and the depth of invasion in oropharyngeal cancer. METHODS: The study included patients with 90 oral carcinomas and 66 oropharyngeal carcinomas. High-risk HPV in situ hybridization was performed to detect HPV infection. RESULTS: The positive rate of high-risk HPV in situ hybridization was 15.4% (24 of 156). There was a significant difference in the fraction of positive high-risk HPV between oral (6.7%) and oropharyngeal (27.3%) cancers (p < .000). Significant correlations were found between positive high-risk HPV and cervical lymph node metastasis, tumor depth of invasion in patients with oropharyngeal cancer (p = .002, p = .016, respectively). There was a statistically significant association between high-risk HPV positivity and the disease-specific survival in patients with oropharyngeal cancer (p = .035). CONCLUSION: High-risk HPV infection was significantly related to cervical lymph node metastasis and depth of invasion in patients with oropharyngeal cancer. © 2011 Wiley Periodicals, Inc. Head Neck, 2012. SN - 1097-0347 UR - https://www.unboundmedicine.com/medline/citation/21438064/High_risk_human_papillomavirus_and_cervical_lymph_node_metastasis_in_patients_with_oropharyngeal_cancer_ L2 - https://doi.org/10.1002/hed.21697 DB - PRIME DP - Unbound Medicine ER -