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Chronic intrathecal infusion of gabapentin prevents nerve ligation-induced pain in rats.
Br J Anaesth. 2011 May; 106(5):699-705.BJ

Abstract

BACKGROUND

Gabapentin is an anticonvulsant and adjuvant analgesic. It is effective in several pain studies. Neuropathic pain is the most difficult type of pain to treat. In this study, we examined if intrathecal gabapentin could prevent nerve injury-induced pain.

METHODS

Under isoflurane anaesthesia, male Sprague-Dawley rats (200-250 g) underwent right L5/6 spinal nerve ligation and placement of an intrathecal catheter connected to an infusion pump. After surgery, intrathecal saline or gabapentin (20 µg h(-1)) was given for 7 days (n=8 per group). The right hind paw withdrawal threshold to von Frey filament stimuli and withdrawal latency to radiant heat were determined before (baseline) and once daily for 7 days after surgery. Haematoxylin and eosin and toluidine blue staining were used to evaluate the neurotoxicity of gabapentin (40 µg h(-1)).

RESULTS

Seven days after nerve ligation, the affected paw withdrawal threshold and latency of saline-treated rats decreased from the baseline 11.7 (11.7-22.2) [median (inter-quartile range)] to 1.6 (0.9-3.2) g and 10.8 (10.5-11.2) to 4.3 (4.2-7) s, respectively. Rats receiving gabapentin (20 µg h(-1)) had higher withdrawal threshold [9.9 (9.9-19.3) g] and latency [11.5 (9.7-11.9) s] on day 7 after ligation. No obvious histopathological change or growth retardation was detected after intrathecal gabapentin (40 µg h(-1)) infusion.

CONCLUSIONS

We showed a preventative effect of intrathecal gabapentin on the development of nerve injury-induced mechanical allodynia and thermal hyperalgesia. Our data suggest that continuous intrathecal gabapentin may be considered as an alternative for the prevention of nerve injury-induced pain.

Authors+Show Affiliations

Department of Anaesthesiology, Mackay Memorial Hospital, Taipei 25160, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21441243

Citation

Chu, L-C, et al. "Chronic Intrathecal Infusion of Gabapentin Prevents Nerve Ligation-induced Pain in Rats." British Journal of Anaesthesia, vol. 106, no. 5, 2011, pp. 699-705.
Chu LC, Tsaur ML, Lin CS, et al. Chronic intrathecal infusion of gabapentin prevents nerve ligation-induced pain in rats. Br J Anaesth. 2011;106(5):699-705.
Chu, L. C., Tsaur, M. L., Lin, C. S., Hung, Y. C., Wang, T. Y., Chen, C. C., & Cheng, J. K. (2011). Chronic intrathecal infusion of gabapentin prevents nerve ligation-induced pain in rats. British Journal of Anaesthesia, 106(5), 699-705. https://doi.org/10.1093/bja/aer063
Chu LC, et al. Chronic Intrathecal Infusion of Gabapentin Prevents Nerve Ligation-induced Pain in Rats. Br J Anaesth. 2011;106(5):699-705. PubMed PMID: 21441243.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic intrathecal infusion of gabapentin prevents nerve ligation-induced pain in rats. AU - Chu,L-C, AU - Tsaur,M-L, AU - Lin,C-S, AU - Hung,Y-C, AU - Wang,T-Y, AU - Chen,C-C, AU - Cheng,J-K, Y1 - 2011/03/25/ PY - 2011/3/29/entrez PY - 2011/3/29/pubmed PY - 2011/6/24/medline SP - 699 EP - 705 JF - British journal of anaesthesia JO - Br J Anaesth VL - 106 IS - 5 N2 - BACKGROUND: Gabapentin is an anticonvulsant and adjuvant analgesic. It is effective in several pain studies. Neuropathic pain is the most difficult type of pain to treat. In this study, we examined if intrathecal gabapentin could prevent nerve injury-induced pain. METHODS: Under isoflurane anaesthesia, male Sprague-Dawley rats (200-250 g) underwent right L5/6 spinal nerve ligation and placement of an intrathecal catheter connected to an infusion pump. After surgery, intrathecal saline or gabapentin (20 µg h(-1)) was given for 7 days (n=8 per group). The right hind paw withdrawal threshold to von Frey filament stimuli and withdrawal latency to radiant heat were determined before (baseline) and once daily for 7 days after surgery. Haematoxylin and eosin and toluidine blue staining were used to evaluate the neurotoxicity of gabapentin (40 µg h(-1)). RESULTS: Seven days after nerve ligation, the affected paw withdrawal threshold and latency of saline-treated rats decreased from the baseline 11.7 (11.7-22.2) [median (inter-quartile range)] to 1.6 (0.9-3.2) g and 10.8 (10.5-11.2) to 4.3 (4.2-7) s, respectively. Rats receiving gabapentin (20 µg h(-1)) had higher withdrawal threshold [9.9 (9.9-19.3) g] and latency [11.5 (9.7-11.9) s] on day 7 after ligation. No obvious histopathological change or growth retardation was detected after intrathecal gabapentin (40 µg h(-1)) infusion. CONCLUSIONS: We showed a preventative effect of intrathecal gabapentin on the development of nerve injury-induced mechanical allodynia and thermal hyperalgesia. Our data suggest that continuous intrathecal gabapentin may be considered as an alternative for the prevention of nerve injury-induced pain. SN - 1471-6771 UR - https://www.unboundmedicine.com/medline/citation/21441243/Chronic_intrathecal_infusion_of_gabapentin_prevents_nerve_ligation_induced_pain_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0007-0912(17)33220-8 DB - PRIME DP - Unbound Medicine ER -