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MRI study of the changes in crystalline lens shape with accommodation and aging in humans.
J Vis 2011; 11(3)JV

Abstract

Magnetic Resonance Imaging was used to study changes in the crystalline lens and ciliary body with accommodation and aging. Monocular images were obtained in 15 young (19-29 years) and 15 older (60-70 years) emmetropes when viewing at far (6 m) and at individual near points (14.5 to 20.9 cm) in the younger group. With accommodation, lens thickness increased (mean ± 95% CI: 0.33 ± 0.06 mm) by a similar magnitude to the decrease in anterior chamber depth (0.31 ± 0.07 mm) and equatorial diameter (0.32 ± 0.04 mm) with a decrease in the radius of curvature of the posterior lens surface (0.58 ± 0.30 mm). Anterior lens surface shape could not be determined due to the overlapping region with the iris. Ciliary ring diameter decreased (0.44 ± 0.17 mm) with no decrease in circumlental space or forward ciliary body movement. With aging, lens thickness increased (mean ± 95% CI: 0.97 ± 0.24 mm) similar in magnitude to the sum of the decrease in anterior chamber depth (0.45 ± 0.21 mm) and increase in anterior segment depth (0.52 ± 0.23 mm). Equatorial lens diameter increased (0.28 ± 0.23 mm) with no change in the posterior lens surface radius of curvature. Ciliary ring diameter decreased (0.57 ± 0.41 mm) with reduced circumlental space (0.43 ± 0.15 mm) and no forward ciliary body movement. Accommodative changes support the Helmholtz theory of accommodation including an increase in posterior lens surface curvature. Certain aspects of aging changes mimic accommodation.

Authors+Show Affiliations

Abbott Medical Optics, Milpitas, CA, USA. sanjeev.k@amo.abbott.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21441300

Citation

Kasthurirangan, Sanjeev, et al. "MRI Study of the Changes in Crystalline Lens Shape With Accommodation and Aging in Humans." Journal of Vision, vol. 11, no. 3, 2011.
Kasthurirangan S, Markwell EL, Atchison DA, et al. MRI study of the changes in crystalline lens shape with accommodation and aging in humans. J Vis. 2011;11(3).
Kasthurirangan, S., Markwell, E. L., Atchison, D. A., & Pope, J. M. (2011). MRI study of the changes in crystalline lens shape with accommodation and aging in humans. Journal of Vision, 11(3), doi:10.1167/11.3.19.
Kasthurirangan S, et al. MRI Study of the Changes in Crystalline Lens Shape With Accommodation and Aging in Humans. J Vis. 2011 Mar 25;11(3) PubMed PMID: 21441300.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MRI study of the changes in crystalline lens shape with accommodation and aging in humans. AU - Kasthurirangan,Sanjeev, AU - Markwell,Emma L, AU - Atchison,David A, AU - Pope,James M, Y1 - 2011/03/25/ PY - 2011/3/29/entrez PY - 2011/3/29/pubmed PY - 2011/7/19/medline JF - Journal of vision JO - J Vis VL - 11 IS - 3 N2 - Magnetic Resonance Imaging was used to study changes in the crystalline lens and ciliary body with accommodation and aging. Monocular images were obtained in 15 young (19-29 years) and 15 older (60-70 years) emmetropes when viewing at far (6 m) and at individual near points (14.5 to 20.9 cm) in the younger group. With accommodation, lens thickness increased (mean ± 95% CI: 0.33 ± 0.06 mm) by a similar magnitude to the decrease in anterior chamber depth (0.31 ± 0.07 mm) and equatorial diameter (0.32 ± 0.04 mm) with a decrease in the radius of curvature of the posterior lens surface (0.58 ± 0.30 mm). Anterior lens surface shape could not be determined due to the overlapping region with the iris. Ciliary ring diameter decreased (0.44 ± 0.17 mm) with no decrease in circumlental space or forward ciliary body movement. With aging, lens thickness increased (mean ± 95% CI: 0.97 ± 0.24 mm) similar in magnitude to the sum of the decrease in anterior chamber depth (0.45 ± 0.21 mm) and increase in anterior segment depth (0.52 ± 0.23 mm). Equatorial lens diameter increased (0.28 ± 0.23 mm) with no change in the posterior lens surface radius of curvature. Ciliary ring diameter decreased (0.57 ± 0.41 mm) with reduced circumlental space (0.43 ± 0.15 mm) and no forward ciliary body movement. Accommodative changes support the Helmholtz theory of accommodation including an increase in posterior lens surface curvature. Certain aspects of aging changes mimic accommodation. SN - 1534-7362 UR - https://www.unboundmedicine.com/medline/citation/21441300/MRI_study_of_the_changes_in_crystalline_lens_shape_with_accommodation_and_aging_in_humans L2 - http://jov.arvojournals.org/article.aspx?doi=10.1167/11.3.19 DB - PRIME DP - Unbound Medicine ER -