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Prognostic value of coronary computed tomographic angiography in patients with arterial hypertension.
Int J Cardiovasc Imaging. 2012 Mar; 28(3):641-50.IJ

Abstract

Patients with arterial hypertension have a high risk of developing coronary artery disease (CAD), but noninvasive diagnosis of CAD remains difficult. We assessed the ability of coronary CT angiography (CCTA) to detect CAD and to predict subsequent cardiac events in hypertensive patients. We compared 906 hypertensive patients without known CAD undergoing CCTA with 906 matched normotensive patients. Besides calcium score and the degree of the most severe stenosis, the number of coronary segments with atherosclerotic changes was recorded. The primary endpoint was the occurrence of hard cardiac events defined as all cause death, nonfatal myocardial infarction or unstable angina requiring hospitalization. During a median follow-up of 29 months, there were 17 hard cardiac events in the hypertensive group and 13 events in the control group. The best predictor of events in hypertensive patients was the degree of the most severe stenosis (C-index 0.705, P < 0.001, both corrected for clinical risk). The annual event rate was 0.3% for patients without obstructive CAD and 1.5% for patients with obstructive CAD. In hypertensive patients without known CAD, coronary CT angiography allows for the identification of patients at high risk for incident cardiac events.

Authors+Show Affiliations

Klinik für Herz- und Kreislauferkrankungen, Deutsches Herzzentrum München, Technische Universität München, Lazarettstrasse 36, 80636 München, Germany. mhy@dhm.mhn.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21442263

Citation

Hadamitzky, Martin, et al. "Prognostic Value of Coronary Computed Tomographic Angiography in Patients With Arterial Hypertension." The International Journal of Cardiovascular Imaging, vol. 28, no. 3, 2012, pp. 641-50.
Hadamitzky M, Meyer T, Hein F, et al. Prognostic value of coronary computed tomographic angiography in patients with arterial hypertension. Int J Cardiovasc Imaging. 2012;28(3):641-50.
Hadamitzky, M., Meyer, T., Hein, F., Bischoff, B., Byrne, R. A., Martinoff, S., Schömig, A., & Hausleiter, J. (2012). Prognostic value of coronary computed tomographic angiography in patients with arterial hypertension. The International Journal of Cardiovascular Imaging, 28(3), 641-50. https://doi.org/10.1007/s10554-011-9851-0
Hadamitzky M, et al. Prognostic Value of Coronary Computed Tomographic Angiography in Patients With Arterial Hypertension. Int J Cardiovasc Imaging. 2012;28(3):641-50. PubMed PMID: 21442263.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prognostic value of coronary computed tomographic angiography in patients with arterial hypertension. AU - Hadamitzky,Martin, AU - Meyer,Tanja, AU - Hein,Franziska, AU - Bischoff,Bernhard, AU - Byrne,Robert A, AU - Martinoff,Stefan, AU - Schömig,Albert, AU - Hausleiter,Jörg, Y1 - 2011/03/26/ PY - 2010/12/22/received PY - 2011/03/11/accepted PY - 2011/3/29/entrez PY - 2011/3/29/pubmed PY - 2012/9/7/medline SP - 641 EP - 50 JF - The international journal of cardiovascular imaging JO - Int J Cardiovasc Imaging VL - 28 IS - 3 N2 - Patients with arterial hypertension have a high risk of developing coronary artery disease (CAD), but noninvasive diagnosis of CAD remains difficult. We assessed the ability of coronary CT angiography (CCTA) to detect CAD and to predict subsequent cardiac events in hypertensive patients. We compared 906 hypertensive patients without known CAD undergoing CCTA with 906 matched normotensive patients. Besides calcium score and the degree of the most severe stenosis, the number of coronary segments with atherosclerotic changes was recorded. The primary endpoint was the occurrence of hard cardiac events defined as all cause death, nonfatal myocardial infarction or unstable angina requiring hospitalization. During a median follow-up of 29 months, there were 17 hard cardiac events in the hypertensive group and 13 events in the control group. The best predictor of events in hypertensive patients was the degree of the most severe stenosis (C-index 0.705, P < 0.001, both corrected for clinical risk). The annual event rate was 0.3% for patients without obstructive CAD and 1.5% for patients with obstructive CAD. In hypertensive patients without known CAD, coronary CT angiography allows for the identification of patients at high risk for incident cardiac events. SN - 1875-8312 UR - https://www.unboundmedicine.com/medline/citation/21442263/Prognostic_value_of_coronary_computed_tomographic_angiography_in_patients_with_arterial_hypertension_ L2 - https://doi.org/10.1007/s10554-011-9851-0 DB - PRIME DP - Unbound Medicine ER -