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Effects of probiotic fermented milk on symptoms and intestinal flora in patients with irritable bowel syndrome: a randomized, placebo-controlled trial.
Scand J Gastroenterol 2011; 46(6):663-72SJ

Abstract

OBJECTIVE

The effect of probiotics on IBS symptoms has been mixed, but remains an intriguing treatment option with appeal to the patient.

MATERIAL AND METHODS

Patients fulfilling the Rome II criteria were randomized double-blind to a daily intake of 500 ml of fermented milk containing at least 5 × 10(7) CFU/ml of Lactobacillus paracasei ssp paracasei F19, Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 or an equal volume of acidified milk for 8 weeks. Symptoms were assessed at baseline and weekly using a disease-specific validated symptom rating scale (IBS-SSI). The predefined primary outcome measure was patient reported adequate symptom relief. Adherence to study protocol were assessed by performing stool samples at the of the treatment period.

RESULTS

Eight-one patients were screened. Sixty-four patients were randomized; 18 patients did not complete the study due to protocol violations or withdrew due to lack of effect. Fifty-two patients (13 males) completed the study as per protocol; mean age was 51.3 years (range 29-67). The proportion of patients reporting adequate symptom relief increased in both patient groups, but there was not any statistical difference between the groups. IBS-SSI scores did not differ statistically between the groups at the end of the treatment period, but improved during the study period in both groups.

CONCLUSIONS

During this 8-week trial gastrointestinal symptoms improved. However, there was no difference between treatment with fermented milk containing probiotics or acidified milk. The effect of probiotics on IBS symptoms remains uncertain and further studies are warranted.

Authors+Show Affiliations

Department of Medicine, Glostrup University Hospital, Glostrup, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21443416

Citation

Søndergaard, Bo, et al. "Effects of Probiotic Fermented Milk On Symptoms and Intestinal Flora in Patients With Irritable Bowel Syndrome: a Randomized, Placebo-controlled Trial." Scandinavian Journal of Gastroenterology, vol. 46, no. 6, 2011, pp. 663-72.
Søndergaard B, Olsson J, Ohlson K, et al. Effects of probiotic fermented milk on symptoms and intestinal flora in patients with irritable bowel syndrome: a randomized, placebo-controlled trial. Scand J Gastroenterol. 2011;46(6):663-72.
Søndergaard, B., Olsson, J., Ohlson, K., Svensson, U., Bytzer, P., & Ekesbo, R. (2011). Effects of probiotic fermented milk on symptoms and intestinal flora in patients with irritable bowel syndrome: a randomized, placebo-controlled trial. Scandinavian Journal of Gastroenterology, 46(6), pp. 663-72. doi:10.3109/00365521.2011.565066.
Søndergaard B, et al. Effects of Probiotic Fermented Milk On Symptoms and Intestinal Flora in Patients With Irritable Bowel Syndrome: a Randomized, Placebo-controlled Trial. Scand J Gastroenterol. 2011;46(6):663-72. PubMed PMID: 21443416.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of probiotic fermented milk on symptoms and intestinal flora in patients with irritable bowel syndrome: a randomized, placebo-controlled trial. AU - Søndergaard,Bo, AU - Olsson,Johan, AU - Ohlson,Kajsa, AU - Svensson,Ulla, AU - Bytzer,Peter, AU - Ekesbo,Rickard, Y1 - 2011/03/28/ PY - 2011/3/30/entrez PY - 2011/3/30/pubmed PY - 2011/9/7/medline SP - 663 EP - 72 JF - Scandinavian journal of gastroenterology JO - Scand. J. Gastroenterol. VL - 46 IS - 6 N2 - OBJECTIVE: The effect of probiotics on IBS symptoms has been mixed, but remains an intriguing treatment option with appeal to the patient. MATERIAL AND METHODS: Patients fulfilling the Rome II criteria were randomized double-blind to a daily intake of 500 ml of fermented milk containing at least 5 × 10(7) CFU/ml of Lactobacillus paracasei ssp paracasei F19, Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 or an equal volume of acidified milk for 8 weeks. Symptoms were assessed at baseline and weekly using a disease-specific validated symptom rating scale (IBS-SSI). The predefined primary outcome measure was patient reported adequate symptom relief. Adherence to study protocol were assessed by performing stool samples at the of the treatment period. RESULTS: Eight-one patients were screened. Sixty-four patients were randomized; 18 patients did not complete the study due to protocol violations or withdrew due to lack of effect. Fifty-two patients (13 males) completed the study as per protocol; mean age was 51.3 years (range 29-67). The proportion of patients reporting adequate symptom relief increased in both patient groups, but there was not any statistical difference between the groups. IBS-SSI scores did not differ statistically between the groups at the end of the treatment period, but improved during the study period in both groups. CONCLUSIONS: During this 8-week trial gastrointestinal symptoms improved. However, there was no difference between treatment with fermented milk containing probiotics or acidified milk. The effect of probiotics on IBS symptoms remains uncertain and further studies are warranted. SN - 1502-7708 UR - https://www.unboundmedicine.com/medline/citation/21443416/Effects_of_probiotic_fermented_milk_on_symptoms_and_intestinal_flora_in_patients_with_irritable_bowel_syndrome:_a_randomized_placebo_controlled_trial_ L2 - http://www.tandfonline.com/doi/full/10.3109/00365521.2011.565066 DB - PRIME DP - Unbound Medicine ER -