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Small intestinal bacterial overgrowth (SIBO) in irritable bowel syndrome: frequency and predictors.
J Gastroenterol Hepatol. 2011 Apr; 26 Suppl 3:135-8.JG

Abstract

OBJECTIVE AND BACKGROUND

Small intestinal bacterial overgrowth (SIBO) has been implicated in pathogenesis of IBS. We aimed to study frequency and predictors of SIBO in patients with IBS.

METHODOLOGY

We included 59 consecutive patients of IBS & 37 healthy controls (HC). Evaluation for SIBO was done by glucose breath test (GBT) using 100 gm of glucose after an overnight fast. Breath hydrogen & methane concentration were noted at baseline & every 15 min after administration of glucose for a total of 3 h. Persistent rise in breath hydrogen or methane > 12 ppm above basal was considered diagnostic of SIBO.

RESULTS

Of 59 patients, 27 were diarrhoea predominant (D-IBS), 11 were constipation predominant (C-IBS) and 21 were mixed type (M-IBS). Median age of patients (34 [18-47] years) were comparable to controls (35 [20-48] years) (P = 0.21). Patient group was similar to HC in gender distribution (male 41/59 [69.5%]vs 25/37 [67.6%], P = 0.36). SIBO was more frequent in patients with IBS than HC (14/59 [23.7%]vs 1/37 [2.7%], P = 0.008). Patients with D-IBS more often had SIBO as compared to non-D-IBS (10/27 [37%]vs 4/32 [12.5%], P = 0.02). C-IBS had lowest frequency of SIBO (1/11 [9%]) among all IBS subgroups. Patients with history of bloating more often had SIBO as compared to those without this symptom (11/23 [47.8%]vs 3/36 [8.3%], P = 0.002). Among IBS patients, females more often had SIBO as compared to males (8/18 [44.4%]vs 6/41 [14.6%], P = 0.01).

CONCLUSIONS

SIBO was more frequent in patients with IBS as compared to healthy controls. D-IBS subtype, female gender & bloating were predictors of SIBO in patients with IBS.

Authors+Show Affiliations

Department of Gastroenterology, GB Pant Hospital, New Delhi, India. sanjeevgastro@rediffmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21443727

Citation

Sachdeva, Sanjeev, et al. "Small Intestinal Bacterial Overgrowth (SIBO) in Irritable Bowel Syndrome: Frequency and Predictors." Journal of Gastroenterology and Hepatology, vol. 26 Suppl 3, 2011, pp. 135-8.
Sachdeva S, Rawat AK, Reddy RS, et al. Small intestinal bacterial overgrowth (SIBO) in irritable bowel syndrome: frequency and predictors. J Gastroenterol Hepatol. 2011;26 Suppl 3:135-8.
Sachdeva, S., Rawat, A. K., Reddy, R. S., & Puri, A. S. (2011). Small intestinal bacterial overgrowth (SIBO) in irritable bowel syndrome: frequency and predictors. Journal of Gastroenterology and Hepatology, 26 Suppl 3, 135-8. https://doi.org/10.1111/j.1440-1746.2011.06654.x
Sachdeva S, et al. Small Intestinal Bacterial Overgrowth (SIBO) in Irritable Bowel Syndrome: Frequency and Predictors. J Gastroenterol Hepatol. 2011;26 Suppl 3:135-8. PubMed PMID: 21443727.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Small intestinal bacterial overgrowth (SIBO) in irritable bowel syndrome: frequency and predictors. AU - Sachdeva,Sanjeev, AU - Rawat,Ajit Kumar, AU - Reddy,Ravi Sankar, AU - Puri,Amarender Singh, PY - 2011/3/30/entrez PY - 2011/4/2/pubmed PY - 2011/7/14/medline SP - 135 EP - 8 JF - Journal of gastroenterology and hepatology JO - J Gastroenterol Hepatol VL - 26 Suppl 3 N2 - OBJECTIVE AND BACKGROUND: Small intestinal bacterial overgrowth (SIBO) has been implicated in pathogenesis of IBS. We aimed to study frequency and predictors of SIBO in patients with IBS. METHODOLOGY: We included 59 consecutive patients of IBS & 37 healthy controls (HC). Evaluation for SIBO was done by glucose breath test (GBT) using 100 gm of glucose after an overnight fast. Breath hydrogen & methane concentration were noted at baseline & every 15 min after administration of glucose for a total of 3 h. Persistent rise in breath hydrogen or methane > 12 ppm above basal was considered diagnostic of SIBO. RESULTS: Of 59 patients, 27 were diarrhoea predominant (D-IBS), 11 were constipation predominant (C-IBS) and 21 were mixed type (M-IBS). Median age of patients (34 [18-47] years) were comparable to controls (35 [20-48] years) (P = 0.21). Patient group was similar to HC in gender distribution (male 41/59 [69.5%]vs 25/37 [67.6%], P = 0.36). SIBO was more frequent in patients with IBS than HC (14/59 [23.7%]vs 1/37 [2.7%], P = 0.008). Patients with D-IBS more often had SIBO as compared to non-D-IBS (10/27 [37%]vs 4/32 [12.5%], P = 0.02). C-IBS had lowest frequency of SIBO (1/11 [9%]) among all IBS subgroups. Patients with history of bloating more often had SIBO as compared to those without this symptom (11/23 [47.8%]vs 3/36 [8.3%], P = 0.002). Among IBS patients, females more often had SIBO as compared to males (8/18 [44.4%]vs 6/41 [14.6%], P = 0.01). CONCLUSIONS: SIBO was more frequent in patients with IBS as compared to healthy controls. D-IBS subtype, female gender & bloating were predictors of SIBO in patients with IBS. SN - 1440-1746 UR - https://www.unboundmedicine.com/medline/citation/21443727/Small_intestinal_bacterial_overgrowth__SIBO__in_irritable_bowel_syndrome:_frequency_and_predictors_ L2 - https://doi.org/10.1111/j.1440-1746.2011.06654.x DB - PRIME DP - Unbound Medicine ER -