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Developments in administration of growth hormone treatment: focus on Norditropin® Flexpro®.
Patient Prefer Adherence 2011; 5:117-24PP

Abstract

Recombinant human growth hormone is used for the treatment of growth failure in children and metabolic dysfunction in adults with growth hormone deficiency. However, conventional growth hormone therapy requires daily subcutaneous injections that may affect treatment adherence, and subsequently efficacy outcomes. To enhance potential treatment adherence, improved ease of use of growth hormone delivery devices and long-acting growth hormone formulations are now being developed. Flexpro(®), approved by the US Food and Drug Administration in March 2010, is the most recent pen device developed by Novo Nordisk A/S to deliver Norditropin(®). It is a multidose, premixed, preloaded, disposable pen device that requires relatively less force to inject and does not require refrigeration after initial use. Dose adjustments can be optimized by small dose increments of the pen delivery device at 0.025 mg, 0.05 mg and 0.1 mg. In addition, for patients with needle anxiety, NovoFine(®) needles, some of the shortest and thinnest available, and Autocover(®), which hides the needle during injections, can be used with the Flexpro pen device. This article reviews the Norditropin Flexpro pen device in the context of other growth hormone delivery devices, sustained-release growth hormone formulations in development, and future prospects.

Authors+Show Affiliations

Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine, Oregon Health and Science University, Portland, Oregon, USA. yuenk@ohsu.eduNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21448295

Citation

Yuen, Kevin C J., and Rakesh Amin. "Developments in Administration of Growth Hormone Treatment: Focus On Norditropin® Flexpro®." Patient Preference and Adherence, vol. 5, 2011, pp. 117-24.
Yuen KC, Amin R. Developments in administration of growth hormone treatment: focus on Norditropin® Flexpro®. Patient Prefer Adherence. 2011;5:117-24.
Yuen, K. C., & Amin, R. (2011). Developments in administration of growth hormone treatment: focus on Norditropin® Flexpro®. Patient Preference and Adherence, 5, pp. 117-24. doi:10.2147/PPA.S10985.
Yuen KC, Amin R. Developments in Administration of Growth Hormone Treatment: Focus On Norditropin® Flexpro®. Patient Prefer Adherence. 2011 Mar 10;5:117-24. PubMed PMID: 21448295.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Developments in administration of growth hormone treatment: focus on Norditropin® Flexpro®. AU - Yuen,Kevin C J, AU - Amin,Rakesh, Y1 - 2011/03/10/ PY - 2011/03/09/received PY - 2011/3/31/entrez PY - 2011/3/31/pubmed PY - 2011/3/31/medline KW - adherence KW - administration KW - device KW - growth hormone KW - pen KW - treatment SP - 117 EP - 24 JF - Patient preference and adherence JO - Patient Prefer Adherence VL - 5 N2 - Recombinant human growth hormone is used for the treatment of growth failure in children and metabolic dysfunction in adults with growth hormone deficiency. However, conventional growth hormone therapy requires daily subcutaneous injections that may affect treatment adherence, and subsequently efficacy outcomes. To enhance potential treatment adherence, improved ease of use of growth hormone delivery devices and long-acting growth hormone formulations are now being developed. Flexpro(®), approved by the US Food and Drug Administration in March 2010, is the most recent pen device developed by Novo Nordisk A/S to deliver Norditropin(®). It is a multidose, premixed, preloaded, disposable pen device that requires relatively less force to inject and does not require refrigeration after initial use. Dose adjustments can be optimized by small dose increments of the pen delivery device at 0.025 mg, 0.05 mg and 0.1 mg. In addition, for patients with needle anxiety, NovoFine(®) needles, some of the shortest and thinnest available, and Autocover(®), which hides the needle during injections, can be used with the Flexpro pen device. This article reviews the Norditropin Flexpro pen device in the context of other growth hormone delivery devices, sustained-release growth hormone formulations in development, and future prospects. SN - 1177-889X UR - https://www.unboundmedicine.com/medline/citation/21448295/Developments_in_administration_of_growth_hormone_treatment:_focus_on_Norditropin®_Flexpro® L2 - https://dx.doi.org/10.2147/PPA.S10985 DB - PRIME DP - Unbound Medicine ER -