Tags

Type your tag names separated by a space and hit enter

A novel three-layered tablet for extended release with various layer formulations and in vitro release profiles.
Drug Dev Ind Pharm. 2011 Jun; 37(6):664-72.DD

Abstract

A novel three-layered tablet consisting of a water-soluble mid-layer and two barrier layers with swellable polymers was investigated to develop a preferable once-a-day formulation containing terazosin HCl as a hydrophilic model drug. When the tablet was exposed to a release medium, the medium quickly permeated to the mid-layer and the two barrier layers swelled surrounding the mid-layer rapidly. It facilitated the tablet to absorb a lot of water compared with monolithic matrix. Moreover, formation of a lot of pores in the tablet during dissolution could be observed, suggesting significant water absorption in the inner matrix and swollen polymers of the tablet. Barrier layers influenced drug release profiles significantly, potentially due to differences in viscosity after swelling that produce different diffusion coefficients and mechanical strength. The drug in the mid-layer showed the sigmoid type of release pattern because a period of time might be needed to release the drug from the mid-layer through the barrier layers, but the drug in barrier layers showed the typical release pattern of monolithic matrix. As the amount of water-soluble excipient in the mid-layer increased, the degree of swelling also increased, suggesting that its amount in the layer may affect the overall swelling properties of the tablet. It was also shown that more hydrophilic mid-layer caused faster erosion rate, which was related to the results of swelling property. The three-layered tablets showed more consistent release kinetics than the matrix tablets. These results can give good information for the development of sustained drug delivery systems, especially once-a-day administration.

Authors+Show Affiliations

GL PharmTech Corp., Seongnam, Gyeonggi, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21449708

Citation

Park, Jun Sang, et al. "A Novel Three-layered Tablet for Extended Release With Various Layer Formulations and in Vitro Release Profiles." Drug Development and Industrial Pharmacy, vol. 37, no. 6, 2011, pp. 664-72.
Park JS, Shim JY, Park JS, et al. A novel three-layered tablet for extended release with various layer formulations and in vitro release profiles. Drug Dev Ind Pharm. 2011;37(6):664-72.
Park, J. S., Shim, J. Y., Park, J. S., Choi, Y. W., & Jeong, S. H. (2011). A novel three-layered tablet for extended release with various layer formulations and in vitro release profiles. Drug Development and Industrial Pharmacy, 37(6), 664-72. https://doi.org/10.3109/03639045.2010.535211
Park JS, et al. A Novel Three-layered Tablet for Extended Release With Various Layer Formulations and in Vitro Release Profiles. Drug Dev Ind Pharm. 2011;37(6):664-72. PubMed PMID: 21449708.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A novel three-layered tablet for extended release with various layer formulations and in vitro release profiles. AU - Park,Jun Sang, AU - Shim,Ji Yeon, AU - Park,Jung Soo, AU - Choi,Young Wook, AU - Jeong,Seong Hoon, Y1 - 2011/03/30/ PY - 2011/4/1/entrez PY - 2011/4/1/pubmed PY - 2011/9/7/medline SP - 664 EP - 72 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 37 IS - 6 N2 - A novel three-layered tablet consisting of a water-soluble mid-layer and two barrier layers with swellable polymers was investigated to develop a preferable once-a-day formulation containing terazosin HCl as a hydrophilic model drug. When the tablet was exposed to a release medium, the medium quickly permeated to the mid-layer and the two barrier layers swelled surrounding the mid-layer rapidly. It facilitated the tablet to absorb a lot of water compared with monolithic matrix. Moreover, formation of a lot of pores in the tablet during dissolution could be observed, suggesting significant water absorption in the inner matrix and swollen polymers of the tablet. Barrier layers influenced drug release profiles significantly, potentially due to differences in viscosity after swelling that produce different diffusion coefficients and mechanical strength. The drug in the mid-layer showed the sigmoid type of release pattern because a period of time might be needed to release the drug from the mid-layer through the barrier layers, but the drug in barrier layers showed the typical release pattern of monolithic matrix. As the amount of water-soluble excipient in the mid-layer increased, the degree of swelling also increased, suggesting that its amount in the layer may affect the overall swelling properties of the tablet. It was also shown that more hydrophilic mid-layer caused faster erosion rate, which was related to the results of swelling property. The three-layered tablets showed more consistent release kinetics than the matrix tablets. These results can give good information for the development of sustained drug delivery systems, especially once-a-day administration. SN - 1520-5762 UR - https://www.unboundmedicine.com/medline/citation/21449708/A_novel_three_layered_tablet_for_extended_release_with_various_layer_formulations_and_in_vitro_release_profiles_ DB - PRIME DP - Unbound Medicine ER -