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Recent progress in capillary electrophoretic analysis of amino acid enantiomers.
J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Nov 01; 879(29):3078-95.JC

Abstract

This review highlights recent progresses in capillary electrophoresis (CE) analysis of amino acid enantiomers in the last decade. Various chiral selectors including cyclodextrins (CDs), bile salts, crown ethers, cinchona alkaloids, metal-chiral amino acid complexes, macrocyclic antibiotics and proteins have been employed to separate amino acid enantiomers. In the CE analysis of amino acids, the selection of the separation mode is one of the most important issues to obtain good resolution of target enantiomers. Among several separation modes, CD-modified capillary zone electrophoresis (CD-CZE), CD electrokinetic chromatography (CDEKC), micellar EKC (MEKC), CD-modified micellar electrokinetic chromatography (CD-MEKC), capillary electrochromatography (CEC), ligand-exchange CE (LE-CE), and nonaqueous CE (NACE) have been employed to the chiral analysis of amino acids. More than 160 published research articles collected from SciFinder Scholar databases from the year 2001 described the enantioseparations of amino acids by capillary-based electrophoresis. This review provides a comprehensive table listing the CE analysis of amino acid enantiomers with categorizing by the separation modes.

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Authors+Show Affiliations

Kitagawa F
Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Kyoto 615-8510, Japan. fkitagawa@anchem.mc.kyoto-u.ac.jp
Otsuka K
No affiliation info available

MeSH

Amino AcidsAnimalsChromatography, Micellar Electrokinetic CapillaryElectrophoresis, CapillaryHumansPharmaceutical PreparationsStereoisomerism

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

21450540

Citation

Kitagawa, Fumihiko, and Koji Otsuka. "Recent Progress in Capillary Electrophoretic Analysis of Amino Acid Enantiomers." Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, vol. 879, no. 29, 2011, pp. 3078-95.
Kitagawa F, Otsuka K. Recent progress in capillary electrophoretic analysis of amino acid enantiomers. J Chromatogr B Analyt Technol Biomed Life Sci. 2011;879(29):3078-95.
Kitagawa, F., & Otsuka, K. (2011). Recent progress in capillary electrophoretic analysis of amino acid enantiomers. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 879(29), 3078-95. https://doi.org/10.1016/j.jchromb.2011.03.016
Kitagawa F, Otsuka K. Recent Progress in Capillary Electrophoretic Analysis of Amino Acid Enantiomers. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Nov 1;879(29):3078-95. PubMed PMID: 21450540.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recent progress in capillary electrophoretic analysis of amino acid enantiomers. AU - Kitagawa,Fumihiko, AU - Otsuka,Koji, Y1 - 2011/03/12/ PY - 2011/01/15/received PY - 2011/03/02/revised PY - 2011/03/06/accepted PY - 2011/4/1/entrez PY - 2011/4/1/pubmed PY - 2012/3/13/medline SP - 3078 EP - 95 JF - Journal of chromatography. B, Analytical technologies in the biomedical and life sciences JO - J Chromatogr B Analyt Technol Biomed Life Sci VL - 879 IS - 29 N2 - This review highlights recent progresses in capillary electrophoresis (CE) analysis of amino acid enantiomers in the last decade. Various chiral selectors including cyclodextrins (CDs), bile salts, crown ethers, cinchona alkaloids, metal-chiral amino acid complexes, macrocyclic antibiotics and proteins have been employed to separate amino acid enantiomers. In the CE analysis of amino acids, the selection of the separation mode is one of the most important issues to obtain good resolution of target enantiomers. Among several separation modes, CD-modified capillary zone electrophoresis (CD-CZE), CD electrokinetic chromatography (CDEKC), micellar EKC (MEKC), CD-modified micellar electrokinetic chromatography (CD-MEKC), capillary electrochromatography (CEC), ligand-exchange CE (LE-CE), and nonaqueous CE (NACE) have been employed to the chiral analysis of amino acids. More than 160 published research articles collected from SciFinder Scholar databases from the year 2001 described the enantioseparations of amino acids by capillary-based electrophoresis. This review provides a comprehensive table listing the CE analysis of amino acid enantiomers with categorizing by the separation modes. SN - 1873-376X UR - https://www.unboundmedicine.com/medline/citation/21450540/Recent_progress_in_capillary_electrophoretic_analysis_of_amino_acid_enantiomers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1570-0232(11)00163-2 DB - PRIME DP - Unbound Medicine ER -