TY - JOUR T1 - Metabolic syndrome and all-cause mortality, cardiac events, and cardiovascular events: a follow-up study in 25,471 young- and middle-aged Japanese men. AU - Kondo,Takahisa, AU - Osugi,Shigeki, AU - Shimokata,Keiko, AU - Honjo,Haruo, AU - Morita,Yasuhiro, AU - Yamashita,Kentaro, AU - Maeda,Kengo, AU - Muramatsu,Takashi, AU - Shintani,Satoshi, AU - Matsushita,Kunihiro, AU - Murohara,Toyoaki, Y1 - 2011/02/14/ PY - 2011/4/1/entrez PY - 2011/4/1/pubmed PY - 2012/2/7/medline SP - 574 EP - 80 JF - European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology JO - Eur J Cardiovasc Prev Rehabil VL - 18 IS - 4 N2 - AIM: The association between subjects with metabolic syndrome (MS) who were considered not to require medication by their attending physicians and all-cause mortality, ischemic heart disease (IHD) and cardiovascular disease (CVD) remains unknown and should be clarified. METHODS AND RESULTS: This is an observational longitudinal cohort study with a median follow-up of 7.5 years performed for 25,471 Japanese men aged 20-61 years who were not on medication. We used a modified definition of MS from the Japanese Society of Internal Medicine and the NCEP ATPIII, both of which employed body mass index instead of waist circumference. MS was associated with increased rates of all-cause death (adjusted hazard ratio (HR): 4.88 [95% confidence interval, 2.96-7.66]), IHD (3.17 [1.06-7.65]), and CVD (2.63 [1.32-4.72]). In contrast, overweight subjects with no component or one component had similar rates to subjects of normal weight. Any combination of the three MS components was associated with significantly greater rates of all-cause mortality (HR: 3.18-11.2) and IHD (HR: 3.17-8.24), whereas blood pressure elevation plus dyslipidaemia was associated with a significantly higher rate of CVD (HR: 3.27). In any endpoint, MS defined by Japanese criteria had higher HRs than defined by NCEP ATP III criteria. CONCLUSION: Young and middle-aged Japanese men with MS who had been viewed as not needing medication already showed increased rates of all-cause mortality, IHD and CVD. Additionally, the event rate depended on the specific combination of metabolic syndrome components. SN - 1741-8275 UR - https://www.unboundmedicine.com/medline/citation/21450628/Metabolic_syndrome_and_all_cause_mortality_cardiac_events_and_cardiovascular_events:_a_follow_up_study_in_25471_young__and_middle_aged_Japanese_men_ L2 - http://www.diseaseinfosearch.org/result/7590 DB - PRIME DP - Unbound Medicine ER -