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Oropharyngeal squamous cell carcinoma and human papillomavirus-associated cancers in women: epidemiologic evaluation of association.
J Otolaryngol Head Neck Surg. 2011 Feb; 40 Suppl 1:S65-9.JO

Abstract

OBJECTIVE

Human papillomavirus (HPV) is a well-established etiologic factor in oropharyngeal squamous cell carcinoma (OPSCC). The objective of this study was to evaluate the association between OPSCC and HPV-related cancerous lesions of the cervix.

METHODS

Demographic, survival, and pathologic data on all female patients diagnosed with OPSCC in Alberta between 1998 and 2008 were collected. A review of pathology reports in these patients was undertaken to identify HPV-related cancerous lesions of the cervix. Standardized incidence ratios (SIRs) of cervical cancer in oropharyngeal cancer patients were calculated using control data obtained from provincial cancer surveillance. Overall and disease-specific survival of patients with OPSCC only versus patients with OPSCC and cervical cancer was calculated using Kaplan-Meier and Cox regression models.

RESULTS

Our results show a significantly elevated overall incidence of cervical cancer in women with OPSCC in comparison to the control population (SIR 29.4, 95% CI 12.05-74.98). Patients with OPSCC and cervical cancer also had a significantly improved disease-specific survival in comparison to patients with no history of cervical cancer.

CONCLUSIONS

Women with OPSCC have a significantly elevated risk of developing HPV-related genital cancers, which suggests frequent HPV coinfection of oropharyngeal and genital tissues in this patient population. Women with OPSCC with cervical cancer also have an improved disease-specific survival, as previously shown with HPV-associated OPSCC.

Authors+Show Affiliations

Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Alberta, Edmonton, AB.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

21453664

Citation

Biron, Vincent L., et al. "Oropharyngeal Squamous Cell Carcinoma and Human Papillomavirus-associated Cancers in Women: Epidemiologic Evaluation of Association." Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale, vol. 40 Suppl 1, 2011, pp. S65-9.
Biron VL, Côté DW, Seikaly H. Oropharyngeal squamous cell carcinoma and human papillomavirus-associated cancers in women: epidemiologic evaluation of association. J Otolaryngol Head Neck Surg. 2011;40 Suppl 1:S65-9.
Biron, V. L., Côté, D. W., & Seikaly, H. (2011). Oropharyngeal squamous cell carcinoma and human papillomavirus-associated cancers in women: epidemiologic evaluation of association. Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale, 40 Suppl 1, S65-9.
Biron VL, Côté DW, Seikaly H. Oropharyngeal Squamous Cell Carcinoma and Human Papillomavirus-associated Cancers in Women: Epidemiologic Evaluation of Association. J Otolaryngol Head Neck Surg. 2011;40 Suppl 1:S65-9. PubMed PMID: 21453664.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oropharyngeal squamous cell carcinoma and human papillomavirus-associated cancers in women: epidemiologic evaluation of association. AU - Biron,Vincent L, AU - Côté,David W J, AU - Seikaly,Hadi, PY - 2011/4/2/entrez PY - 2011/4/6/pubmed PY - 2011/7/13/medline SP - S65 EP - 9 JF - Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale JO - J Otolaryngol Head Neck Surg VL - 40 Suppl 1 N2 - OBJECTIVE: Human papillomavirus (HPV) is a well-established etiologic factor in oropharyngeal squamous cell carcinoma (OPSCC). The objective of this study was to evaluate the association between OPSCC and HPV-related cancerous lesions of the cervix. METHODS: Demographic, survival, and pathologic data on all female patients diagnosed with OPSCC in Alberta between 1998 and 2008 were collected. A review of pathology reports in these patients was undertaken to identify HPV-related cancerous lesions of the cervix. Standardized incidence ratios (SIRs) of cervical cancer in oropharyngeal cancer patients were calculated using control data obtained from provincial cancer surveillance. Overall and disease-specific survival of patients with OPSCC only versus patients with OPSCC and cervical cancer was calculated using Kaplan-Meier and Cox regression models. RESULTS: Our results show a significantly elevated overall incidence of cervical cancer in women with OPSCC in comparison to the control population (SIR 29.4, 95% CI 12.05-74.98). Patients with OPSCC and cervical cancer also had a significantly improved disease-specific survival in comparison to patients with no history of cervical cancer. CONCLUSIONS: Women with OPSCC have a significantly elevated risk of developing HPV-related genital cancers, which suggests frequent HPV coinfection of oropharyngeal and genital tissues in this patient population. Women with OPSCC with cervical cancer also have an improved disease-specific survival, as previously shown with HPV-associated OPSCC. SN - 1916-0216 UR - https://www.unboundmedicine.com/medline/citation/21453664/Oropharyngeal_squamous_cell_carcinoma_and_human_papillomavirus_associated_cancers_in_women:_epidemiologic_evaluation_of_association_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=21453664.ui DB - PRIME DP - Unbound Medicine ER -