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The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-α-1,3-galactose.

Abstract

BACKGROUND

In 2009, we reported a novel form of delayed anaphylaxis to red meat that is related to serum IgE antibodies to the oligosaccharide galactose-α-1,3-galactose (alpha-gal). Most of these patients had tolerated meat for many years previously. The implication is that some exposure in adult life had stimulated the production of these IgE antibodies.

OBJECTIVES

We sought to investigate possible causes of this IgE antibody response, focusing on evidence related to tick bites, which are common in the region where these reactions occur.

METHODS

Serum assays were carried out with biotinylated proteins and extracts bound to a streptavidin ImmunoCAP.

RESULTS

Prospective studies on IgE antibodies in 3 subjects after tick bites showed an increase in levels of IgE to alpha-gal of 20-fold or greater. Other evidence included (1) a strong correlation between histories of tick bites and levels of IgE to alpha-gal (χ(2) = 26.8, P < .001), (2) evidence that these IgE antibodies are common in areas where the tick Amblyomma americanum is common, and (3) a significant correlation between IgE antibodies to alpha-gal and IgE antibodies to proteins derived from A americanum (r(s) = 0.75, P < .001).

CONCLUSION

The results presented here provide evidence that tick bites are a cause, possibly the only cause, of IgE specific for alpha-gal in this area of the United States. Both the number of subjects becoming sensitized and the titer of IgE antibodies to alpha-gal are striking. Here we report the first example of a response to an ectoparasite giving rise to an important form of food allergy.

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  • Authors+Show Affiliations

    ,

    Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, VA, USA.

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    Source

    MeSH

    Allergens
    Anaphylaxis
    Animals
    Disaccharides
    Food Hypersensitivity
    Humans
    Hypersensitivity, Delayed
    Immunoglobulin E
    Insect Bites and Stings
    Prevalence
    Ticks

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21453959

    Citation

    Commins, Scott P., et al. "The Relevance of Tick Bites to the Production of IgE Antibodies to the Mammalian Oligosaccharide Galactose-α-1,3-galactose." The Journal of Allergy and Clinical Immunology, vol. 127, no. 5, 2011, pp. 1286-93.e6.
    Commins SP, James HR, Kelly LA, et al. The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-α-1,3-galactose. J Allergy Clin Immunol. 2011;127(5):1286-93.e6.
    Commins, S. P., James, H. R., Kelly, L. A., Pochan, S. L., Workman, L. J., Perzanowski, M. S., ... Platts-Mills, T. A. (2011). The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-α-1,3-galactose. The Journal of Allergy and Clinical Immunology, 127(5), pp. 1286-93.e6. doi:10.1016/j.jaci.2011.02.019.
    Commins SP, et al. The Relevance of Tick Bites to the Production of IgE Antibodies to the Mammalian Oligosaccharide Galactose-α-1,3-galactose. J Allergy Clin Immunol. 2011;127(5):1286-93.e6. PubMed PMID: 21453959.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-α-1,3-galactose. AU - Commins,Scott P, AU - James,Hayley R, AU - Kelly,Libby A, AU - Pochan,Shawna L, AU - Workman,Lisa J, AU - Perzanowski,Matthew S, AU - Kocan,Katherine M, AU - Fahy,John V, AU - Nganga,Lucy W, AU - Ronmark,Eva, AU - Cooper,Philip J, AU - Platts-Mills,Thomas A E, Y1 - 2011/03/31/ PY - 2010/11/23/received PY - 2011/01/21/revised PY - 2011/02/04/accepted PY - 2011/4/2/entrez PY - 2011/4/2/pubmed PY - 2011/7/21/medline SP - 1286 EP - 93.e6 JF - The Journal of allergy and clinical immunology JO - J. Allergy Clin. Immunol. VL - 127 IS - 5 N2 - BACKGROUND: In 2009, we reported a novel form of delayed anaphylaxis to red meat that is related to serum IgE antibodies to the oligosaccharide galactose-α-1,3-galactose (alpha-gal). Most of these patients had tolerated meat for many years previously. The implication is that some exposure in adult life had stimulated the production of these IgE antibodies. OBJECTIVES: We sought to investigate possible causes of this IgE antibody response, focusing on evidence related to tick bites, which are common in the region where these reactions occur. METHODS: Serum assays were carried out with biotinylated proteins and extracts bound to a streptavidin ImmunoCAP. RESULTS: Prospective studies on IgE antibodies in 3 subjects after tick bites showed an increase in levels of IgE to alpha-gal of 20-fold or greater. Other evidence included (1) a strong correlation between histories of tick bites and levels of IgE to alpha-gal (χ(2) = 26.8, P < .001), (2) evidence that these IgE antibodies are common in areas where the tick Amblyomma americanum is common, and (3) a significant correlation between IgE antibodies to alpha-gal and IgE antibodies to proteins derived from A americanum (r(s) = 0.75, P < .001). CONCLUSION: The results presented here provide evidence that tick bites are a cause, possibly the only cause, of IgE specific for alpha-gal in this area of the United States. Both the number of subjects becoming sensitized and the titer of IgE antibodies to alpha-gal are striking. Here we report the first example of a response to an ectoparasite giving rise to an important form of food allergy. SN - 1097-6825 UR - https://www.unboundmedicine.com/medline/citation/21453959/The_relevance_of_tick_bites_to_the_production_of_IgE_antibodies_to_the_mammalian_oligosaccharide_galactose_α_13_galactose_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(11)00344-7 DB - PRIME DP - Unbound Medicine ER -