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A comparative study of tea-tree oil versus benzoylperoxide in the treatment of acne.
Med J Aust. 1990 Oct 15; 153(8):455-8.MJ

Abstract

Tea-tree oil (an essential oil of the Australian native tree Melaleuca alternifolia) has long been regarded as a useful topical antiseptic agent in Australia and has been shown to have a variety of antimicrobial activities; however, only anecdotal evidence exists for its efficacy in the treatment of various skin conditions. We have performed a single-blind, randomised clinical trial on 124 patients to evaluate the efficacy and skin tolerance of 5% tea-tree oil gel in the treatment of mild to moderate acne when compared with 5% benzoyl peroxide lotion. The results of this study showed that both 5% tea-tree oil and 5% benzoyl peroxide had a significant effect in ameliorating the patients' acne by reducing the number of inflamed and non-inflamed lesions (open and closed comedones), although the onset of action in the case of tea-tree oil was slower. Encouragingly, fewer side effects were experienced by patients treated with tea-tree oil.

Authors+Show Affiliations

Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, NSW.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

2145499

Citation

Bassett, I B., et al. "A Comparative Study of Tea-tree Oil Versus Benzoylperoxide in the Treatment of Acne." The Medical Journal of Australia, vol. 153, no. 8, 1990, pp. 455-8.
Bassett IB, Pannowitz DL, Barnetson RS. A comparative study of tea-tree oil versus benzoylperoxide in the treatment of acne. Med J Aust. 1990;153(8):455-8.
Bassett, I. B., Pannowitz, D. L., & Barnetson, R. S. (1990). A comparative study of tea-tree oil versus benzoylperoxide in the treatment of acne. The Medical Journal of Australia, 153(8), 455-8.
Bassett IB, Pannowitz DL, Barnetson RS. A Comparative Study of Tea-tree Oil Versus Benzoylperoxide in the Treatment of Acne. Med J Aust. 1990 Oct 15;153(8):455-8. PubMed PMID: 2145499.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparative study of tea-tree oil versus benzoylperoxide in the treatment of acne. AU - Bassett,I B, AU - Pannowitz,D L, AU - Barnetson,R S, PY - 1990/10/15/pubmed PY - 1990/10/15/medline PY - 1990/10/15/entrez SP - 455 EP - 8 JF - The Medical journal of Australia JO - Med. J. Aust. VL - 153 IS - 8 N2 - Tea-tree oil (an essential oil of the Australian native tree Melaleuca alternifolia) has long been regarded as a useful topical antiseptic agent in Australia and has been shown to have a variety of antimicrobial activities; however, only anecdotal evidence exists for its efficacy in the treatment of various skin conditions. We have performed a single-blind, randomised clinical trial on 124 patients to evaluate the efficacy and skin tolerance of 5% tea-tree oil gel in the treatment of mild to moderate acne when compared with 5% benzoyl peroxide lotion. The results of this study showed that both 5% tea-tree oil and 5% benzoyl peroxide had a significant effect in ameliorating the patients' acne by reducing the number of inflamed and non-inflamed lesions (open and closed comedones), although the onset of action in the case of tea-tree oil was slower. Encouragingly, fewer side effects were experienced by patients treated with tea-tree oil. SN - 0025-729X UR - https://www.unboundmedicine.com/medline/citation/2145499/A_comparative_study_of_tea_tree_oil_versus_benzoylperoxide_in_the_treatment_of_acne_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0025-729X&date=1990&volume=153&issue=8&spage=455 DB - PRIME DP - Unbound Medicine ER -