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Dietary fiber is associated with circulating concentrations of C-reactive protein in breast cancer survivors: the HEAL study.
Breast Cancer Res Treat. 2011 Sep; 129(2):485-94.BC

Abstract

Inflammation is a suspected risk factor for breast cancer and its subsequent prognosis. The extent to which dietary and lifestyle factors might influence inflammation is important to examine. Specifically, dietary fiber may reduce systemic inflammation, but this relationship has not been examined among breast cancer survivors. We examined associations between dietary fiber and serum concentrations of C-reactive protein (CRP) and serum amyloid A (SAA), among 698 female breast cancer survivors from the Health, Eating, Activity, and Lifestyle (HEAL) Study. Data are from interviews and clinical visits conducted 24-months post-study enrollment. Multivariate-adjusted linear regression estimated associations of total, soluble, and insoluble fiber with serum concentrations of CRP and SAA. Logistic regression estimated the odds of elevated CRP (defined as >3.0 mg/l) across tertiles of dietary fiber intake. Mean total dietary fiber intake was 13.9 ± 6.4 g/day. Mean CRP and SAA were 3.32 ± 3.66 and 7.73 ± 10.23 mg/l, respectively. We observed a multivariate-adjusted inverse association between total dietary fiber intake and CRP concentrations (β, -0.029; 95% CI, -0.049, -0.008). Results for insoluble fiber were similar (β, -0.039; 95% CI, -0.064, -0.013). Among survivors who consumed >15.5 g/day of insoluble dietary fiber, a 49% reduction in the likelihood of having elevated CRP concentrations (OR, 0.51; 95% CI, 0.27, 0.95) was observed compared to those who consumed <5.4 g/day (P = 0.053). Our results suggest that diets high in fiber may benefit breast cancer survivors via reductions in systemic inflammation; elevated inflammation may be prognostic for reduced survival.

Authors+Show Affiliations

Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M3-B232, Seattle, WA, 98109-1024, USA. avillase@fhcrc.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21455669

Citation

Villaseñor, Adriana, et al. "Dietary Fiber Is Associated With Circulating Concentrations of C-reactive Protein in Breast Cancer Survivors: the HEAL Study." Breast Cancer Research and Treatment, vol. 129, no. 2, 2011, pp. 485-94.
Villaseñor A, Ambs A, Ballard-Barbash R, et al. Dietary fiber is associated with circulating concentrations of C-reactive protein in breast cancer survivors: the HEAL study. Breast Cancer Res Treat. 2011;129(2):485-94.
Villaseñor, A., Ambs, A., Ballard-Barbash, R., Baumgartner, K. B., McTiernan, A., Ulrich, C. M., & Neuhouser, M. L. (2011). Dietary fiber is associated with circulating concentrations of C-reactive protein in breast cancer survivors: the HEAL study. Breast Cancer Research and Treatment, 129(2), 485-94. https://doi.org/10.1007/s10549-011-1474-6
Villaseñor A, et al. Dietary Fiber Is Associated With Circulating Concentrations of C-reactive Protein in Breast Cancer Survivors: the HEAL Study. Breast Cancer Res Treat. 2011;129(2):485-94. PubMed PMID: 21455669.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fiber is associated with circulating concentrations of C-reactive protein in breast cancer survivors: the HEAL study. AU - Villaseñor,Adriana, AU - Ambs,Anita, AU - Ballard-Barbash,Rachel, AU - Baumgartner,Kathy B, AU - McTiernan,Anne, AU - Ulrich,Cornelia M, AU - Neuhouser,Marian L, Y1 - 2011/04/01/ PY - 2010/09/22/received PY - 2011/03/19/accepted PY - 2011/4/2/entrez PY - 2011/4/2/pubmed PY - 2012/9/15/medline SP - 485 EP - 94 JF - Breast cancer research and treatment JO - Breast Cancer Res Treat VL - 129 IS - 2 N2 - Inflammation is a suspected risk factor for breast cancer and its subsequent prognosis. The extent to which dietary and lifestyle factors might influence inflammation is important to examine. Specifically, dietary fiber may reduce systemic inflammation, but this relationship has not been examined among breast cancer survivors. We examined associations between dietary fiber and serum concentrations of C-reactive protein (CRP) and serum amyloid A (SAA), among 698 female breast cancer survivors from the Health, Eating, Activity, and Lifestyle (HEAL) Study. Data are from interviews and clinical visits conducted 24-months post-study enrollment. Multivariate-adjusted linear regression estimated associations of total, soluble, and insoluble fiber with serum concentrations of CRP and SAA. Logistic regression estimated the odds of elevated CRP (defined as >3.0 mg/l) across tertiles of dietary fiber intake. Mean total dietary fiber intake was 13.9 ± 6.4 g/day. Mean CRP and SAA were 3.32 ± 3.66 and 7.73 ± 10.23 mg/l, respectively. We observed a multivariate-adjusted inverse association between total dietary fiber intake and CRP concentrations (β, -0.029; 95% CI, -0.049, -0.008). Results for insoluble fiber were similar (β, -0.039; 95% CI, -0.064, -0.013). Among survivors who consumed >15.5 g/day of insoluble dietary fiber, a 49% reduction in the likelihood of having elevated CRP concentrations (OR, 0.51; 95% CI, 0.27, 0.95) was observed compared to those who consumed <5.4 g/day (P = 0.053). Our results suggest that diets high in fiber may benefit breast cancer survivors via reductions in systemic inflammation; elevated inflammation may be prognostic for reduced survival. SN - 1573-7217 UR - https://www.unboundmedicine.com/medline/citation/21455669/Dietary_fiber_is_associated_with_circulating_concentrations_of_C_reactive_protein_in_breast_cancer_survivors:_the_HEAL_study_ L2 - https://doi.org/10.1007/s10549-011-1474-6 DB - PRIME DP - Unbound Medicine ER -