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Racial/ethnic differences in receipt of pelvic lymph node dissection among men with localized/regional prostate cancer.
Cancer 2011; 117(20):4651-8C

Abstract

BACKGROUND

Black and Hispanic men have a lower prostate cancer (PCa) survival rate than white men. This racial/ethnic survival gap has been explained in part by differences in tumor characteristics, stage at diagnosis, and disparities in receipt of definitive treatment. Another potential contributing factor is racial/ethnic differences in the timely and accurate detection of lymph node metastases. The current study was conducted to examine the association between race/ethnicity and the receipt of pelvic lymph node dissection (PLND) among men with localized/regional PCa.

METHODS

Logistic regression was used to estimate the adjusted odds of undergoing PLND among men who were diagnosed during 2000 to 2002 with PCa, who underwent radical prostatectomy or PLND without radical prostatectomy, and who were diagnosed in regions covered by the Surveillance, Epidemiology, and End Results database (n = 40,848).

RESULTS

Black men were less likely to undergo PLND than white men (odds ratio [OR], 0.91; 95% confidence interval [CI], 0.84-0.98). When the analysis was stratified by PCa grade, black men with well differentiated PCa (OR, 0.48; 95% CI, 0.27-0.84) and poorly differentiated PCa (OR, 0.73; 95% CI, 0.60-0.89) were less likely to undergo PLND than their white counterparts, but racial differences were not observed among men with moderately differentiated PCa (OR, 0.96; 95% CI, 0.88-1.05).

CONCLUSIONS

Among men with poorly differentiated PCa, failure to undergo PLND was associated with worse survival. Racial disparities in the receipt of PLND, especially among men with poorly differentiated PCa, may contribute to racial differences in prostate cancer survival.

Authors+Show Affiliations

Department of Urology, Roswell Park Cancer Institute, Buffalo, New York, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

21456009

Citation

Hayn, Matthew H., et al. "Racial/ethnic Differences in Receipt of Pelvic Lymph Node Dissection Among Men With Localized/regional Prostate Cancer." Cancer, vol. 117, no. 20, 2011, pp. 4651-8.
Hayn MH, Orom H, Shavers VL, et al. Racial/ethnic differences in receipt of pelvic lymph node dissection among men with localized/regional prostate cancer. Cancer. 2011;117(20):4651-8.
Hayn, M. H., Orom, H., Shavers, V. L., Sanda, M. G., Glasgow, M., Mohler, J. L., & Underwood, W. (2011). Racial/ethnic differences in receipt of pelvic lymph node dissection among men with localized/regional prostate cancer. Cancer, 117(20), pp. 4651-8. doi:10.1002/cncr.26103.
Hayn MH, et al. Racial/ethnic Differences in Receipt of Pelvic Lymph Node Dissection Among Men With Localized/regional Prostate Cancer. Cancer. 2011 Oct 15;117(20):4651-8. PubMed PMID: 21456009.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Racial/ethnic differences in receipt of pelvic lymph node dissection among men with localized/regional prostate cancer. AU - Hayn,Matthew H, AU - Orom,Heather, AU - Shavers,Vickie L, AU - Sanda,Martin G, AU - Glasgow,Mark, AU - Mohler,James L, AU - Underwood,Willie,3rd Y1 - 2011/03/31/ PY - 2010/10/13/received PY - 2011/01/31/revised PY - 2011/02/04/accepted PY - 2011/4/2/entrez PY - 2011/4/2/pubmed PY - 2012/12/12/medline SP - 4651 EP - 8 JF - Cancer JO - Cancer VL - 117 IS - 20 N2 - BACKGROUND: Black and Hispanic men have a lower prostate cancer (PCa) survival rate than white men. This racial/ethnic survival gap has been explained in part by differences in tumor characteristics, stage at diagnosis, and disparities in receipt of definitive treatment. Another potential contributing factor is racial/ethnic differences in the timely and accurate detection of lymph node metastases. The current study was conducted to examine the association between race/ethnicity and the receipt of pelvic lymph node dissection (PLND) among men with localized/regional PCa. METHODS: Logistic regression was used to estimate the adjusted odds of undergoing PLND among men who were diagnosed during 2000 to 2002 with PCa, who underwent radical prostatectomy or PLND without radical prostatectomy, and who were diagnosed in regions covered by the Surveillance, Epidemiology, and End Results database (n = 40,848). RESULTS: Black men were less likely to undergo PLND than white men (odds ratio [OR], 0.91; 95% confidence interval [CI], 0.84-0.98). When the analysis was stratified by PCa grade, black men with well differentiated PCa (OR, 0.48; 95% CI, 0.27-0.84) and poorly differentiated PCa (OR, 0.73; 95% CI, 0.60-0.89) were less likely to undergo PLND than their white counterparts, but racial differences were not observed among men with moderately differentiated PCa (OR, 0.96; 95% CI, 0.88-1.05). CONCLUSIONS: Among men with poorly differentiated PCa, failure to undergo PLND was associated with worse survival. Racial disparities in the receipt of PLND, especially among men with poorly differentiated PCa, may contribute to racial differences in prostate cancer survival. SN - 1097-0142 UR - https://www.unboundmedicine.com/medline/citation/21456009/Racial/ethnic_differences_in_receipt_of_pelvic_lymph_node_dissection_among_men_with_localized/regional_prostate_cancer_ L2 - https://doi.org/10.1002/cncr.26103 DB - PRIME DP - Unbound Medicine ER -