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Anaesthesia for a patient with paraneoplastic limbic encephalitis with ovarian teratoma: relationship to anti-N-methyl-D-aspartate receptor antibodies.
Anaesthesia. 2011 Jun; 66(6):515-8.A

Abstract

Paraneoplastic limbic encephalitis associated with ovarian teratoma has recently been related to the development of antibodies to specific heteromers of the N-methyl-d-aspartate receptor and exhibits various manifestations including psychiatric symptoms, hypoventilation, seizures and derangement of autonomic nervous system function. Although recovery can sometimes occur spontaneously, early tumour resection with immunotherapy facilitates earlier recovery. Herein, we describe anaesthetic management of a 20-year-old woman who developed general convulsions and decreased level of consciousness, whom we suspected of having paraneoplastic limbic encephalitis and was scheduled for left ovarian tumour resection. Anaesthetic management was successful with no complications but the case acts as focus of discussion for the potential interaction of N-methyl-D-aspartate receptors and anaesthetic sensitivity.

Authors+Show Affiliations

Department of Anesthesiology and Clinical Research, National Hospital Organization Zentsuji Hospital, Zentsuji, Japan. hirkawa@jun.ncvc.go.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

21457154

Citation

Kawano, H, et al. "Anaesthesia for a Patient With Paraneoplastic Limbic Encephalitis With Ovarian Teratoma: Relationship to anti-N-methyl-D-aspartate Receptor Antibodies." Anaesthesia, vol. 66, no. 6, 2011, pp. 515-8.
Kawano H, Hamaguchi E, Kawahito S, et al. Anaesthesia for a patient with paraneoplastic limbic encephalitis with ovarian teratoma: relationship to anti-N-methyl-D-aspartate receptor antibodies. Anaesthesia. 2011;66(6):515-8.
Kawano, H., Hamaguchi, E., Kawahito, S., Tsutsumi, Y. M., Tanaka, K., Kitahata, H., & Oshita, S. (2011). Anaesthesia for a patient with paraneoplastic limbic encephalitis with ovarian teratoma: relationship to anti-N-methyl-D-aspartate receptor antibodies. Anaesthesia, 66(6), 515-8. https://doi.org/10.1111/j.1365-2044.2011.06707.x
Kawano H, et al. Anaesthesia for a Patient With Paraneoplastic Limbic Encephalitis With Ovarian Teratoma: Relationship to anti-N-methyl-D-aspartate Receptor Antibodies. Anaesthesia. 2011;66(6):515-8. PubMed PMID: 21457154.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anaesthesia for a patient with paraneoplastic limbic encephalitis with ovarian teratoma: relationship to anti-N-methyl-D-aspartate receptor antibodies. AU - Kawano,H, AU - Hamaguchi,E, AU - Kawahito,S, AU - Tsutsumi,Y M, AU - Tanaka,K, AU - Kitahata,H, AU - Oshita,S, Y1 - 2011/04/04/ PY - 2011/4/5/entrez PY - 2011/4/5/pubmed PY - 2011/7/12/medline SP - 515 EP - 8 JF - Anaesthesia JO - Anaesthesia VL - 66 IS - 6 N2 - Paraneoplastic limbic encephalitis associated with ovarian teratoma has recently been related to the development of antibodies to specific heteromers of the N-methyl-d-aspartate receptor and exhibits various manifestations including psychiatric symptoms, hypoventilation, seizures and derangement of autonomic nervous system function. Although recovery can sometimes occur spontaneously, early tumour resection with immunotherapy facilitates earlier recovery. Herein, we describe anaesthetic management of a 20-year-old woman who developed general convulsions and decreased level of consciousness, whom we suspected of having paraneoplastic limbic encephalitis and was scheduled for left ovarian tumour resection. Anaesthetic management was successful with no complications but the case acts as focus of discussion for the potential interaction of N-methyl-D-aspartate receptors and anaesthetic sensitivity. SN - 1365-2044 UR - https://www.unboundmedicine.com/medline/citation/21457154/Anaesthesia_for_a_patient_with_paraneoplastic_limbic_encephalitis_with_ovarian_teratoma:_relationship_to_anti_N_methyl_D_aspartate_receptor_antibodies_ L2 - https://doi.org/10.1111/j.1365-2044.2011.06707.x DB - PRIME DP - Unbound Medicine ER -