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Dual-energy, standard and low-kVp contrast-enhanced CT-cholangiography: a comparative analysis of image quality and radiation exposure.
Eur J Radiol. 2012 Jul; 81(7):1405-12.EJ

Abstract

OBJECTIVE

Quantitative image quality assessment in terms of image noise (IN), contrast-to-noise ratio (CNR), and signal-to-noise ratio (SNR) in relation to required radiation dose (RD) for dual-energy (DE), standard and low-kVp contrast-enhanced computed-tomography (CT) cholangiography.

MATERIALS AND METHODS

For each of 22 DECT-cholangiography examinations, 3 image datasets were analyzed as independent single-source CT-acquisitions at different tube potential, i.e. 80 kVp, 120 kVp-equivalent (linear blended dataset M0.3: 30% 80 kVp, 70% 140 kVp), and 140 kVp. Analysis comprised determination of IN, CNR and SNR in regions of interest (ROI) placed in liver parenchyma and contrasted bile ducts. IN was evaluated as mean standard deviation of 3 ROI placed within liver parenchyma (segments 6/7, 5/8, 2/3); CNR was assessed as bile duct-to-liver parenchyma ratio, and SNR as bile duct-to-image noise ratio. RD in terms of CT dose index (CTDI(vol)), dose-length product (DLP) and effective dose (ED) has been determined for each of the datasets, and compared to console prediction and scan summary values. Using phantom measurements of CTDI(vol), a method for separating comprehensive RD values of DE-acquisitions into the original RD contribution of each tube (80 kVp/140 kVp) has been developed, enabling comparison of all 3 datasets as if independently acquired using single-source "single-energy" technique.

RESULTS

Highest IN was detected for 80 kVp- (38.6 ± 5.1HU), lowest for 120 kVp-equivalent linear blended M0.3-datasets (23.1 ± 3.4HU) with significant differences between all datasets (P<0.001). Highest SNR and CNR were measured for M0.3- (SNR: 14.8 ± 4.1; CNR: 11.6 ± 3.8) and 80 kVp-datasets (SNR: 13.8 ± 4.8; CNR: 11.2 ± 4.5); lowest for 140 kVp-datasets (SNR: 9.5 ± 2.5; CNR: 7.1 ± 2.3) with significant differences between M0.3- and 140 kVp-datasets as well as between 80 kVp- and 140 kVp-datasets (both P<0.001 for both CNR, SNR). CTDI(vol), DLP and ED were reduced by 50% for low-kilovoltage acquisitions (CTDI(vol): 5.5 ± 1.4 mGy; DLP: 127.8 ± 40.1 mGy cm; ED: 1.9 ± 0.6 mSv) compared to comprehensive DE-acquisitions (CTDI(vol): 11.0 ± 2.3 mGy; DLP: 253.8 ± 67.5 mGy cm; ED: 3.8 ± 1.0 mSv, tube contribution: 80 kVp: 44.5%; 140 kVp: 55.5%), and by 20% compared to conventional acquisitions at 120 kVp (CTDI(vol): 6.71 mGy; DLP: 153.5 ± 16.9 mGy cm; ED: 2.3 ± 0.3 mSv).

CONCLUSIONS

Despite higher IN, low-kilovoltage CT-cholangiography reveals no significant difference with respect to CNR and SNR when compared to linear blended images yielded by DECT. Compared to DECT or conventional CT at 120 kVp, contrast-enhanced low-kVp CT cholangiography potentially allows reduction of patient dose by up to 50% or 20%, respectively. Therefore, CT-cholangiography at 80 kVp should be considered as an alternative to DECT-cholangiography whenever DECT is unavailable, or if increased image quality of DECT regarding quantitative bile duct evaluation is not needed for diagnosis.

Authors+Show Affiliations

Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany. wolfram.stiller@med.uni-heidelberg.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21458939

Citation

Stiller, W, et al. "Dual-energy, Standard and low-kVp Contrast-enhanced CT-cholangiography: a Comparative Analysis of Image Quality and Radiation Exposure." European Journal of Radiology, vol. 81, no. 7, 2012, pp. 1405-12.
Stiller W, Schwarzwaelder CB, Sommer CM, et al. Dual-energy, standard and low-kVp contrast-enhanced CT-cholangiography: a comparative analysis of image quality and radiation exposure. Eur J Radiol. 2012;81(7):1405-12.
Stiller, W., Schwarzwaelder, C. B., Sommer, C. M., Veloza, S., Radeleff, B. A., & Kauczor, H. U. (2012). Dual-energy, standard and low-kVp contrast-enhanced CT-cholangiography: a comparative analysis of image quality and radiation exposure. European Journal of Radiology, 81(7), 1405-12. https://doi.org/10.1016/j.ejrad.2011.03.030
Stiller W, et al. Dual-energy, Standard and low-kVp Contrast-enhanced CT-cholangiography: a Comparative Analysis of Image Quality and Radiation Exposure. Eur J Radiol. 2012;81(7):1405-12. PubMed PMID: 21458939.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dual-energy, standard and low-kVp contrast-enhanced CT-cholangiography: a comparative analysis of image quality and radiation exposure. AU - Stiller,W, AU - Schwarzwaelder,C B, AU - Sommer,C M, AU - Veloza,S, AU - Radeleff,B A, AU - Kauczor,H U, Y1 - 2011/04/02/ PY - 2010/11/11/received PY - 2011/02/28/revised PY - 2011/03/03/accepted PY - 2011/4/5/entrez PY - 2011/4/5/pubmed PY - 2012/10/25/medline SP - 1405 EP - 12 JF - European journal of radiology JO - Eur J Radiol VL - 81 IS - 7 N2 - OBJECTIVE: Quantitative image quality assessment in terms of image noise (IN), contrast-to-noise ratio (CNR), and signal-to-noise ratio (SNR) in relation to required radiation dose (RD) for dual-energy (DE), standard and low-kVp contrast-enhanced computed-tomography (CT) cholangiography. MATERIALS AND METHODS: For each of 22 DECT-cholangiography examinations, 3 image datasets were analyzed as independent single-source CT-acquisitions at different tube potential, i.e. 80 kVp, 120 kVp-equivalent (linear blended dataset M0.3: 30% 80 kVp, 70% 140 kVp), and 140 kVp. Analysis comprised determination of IN, CNR and SNR in regions of interest (ROI) placed in liver parenchyma and contrasted bile ducts. IN was evaluated as mean standard deviation of 3 ROI placed within liver parenchyma (segments 6/7, 5/8, 2/3); CNR was assessed as bile duct-to-liver parenchyma ratio, and SNR as bile duct-to-image noise ratio. RD in terms of CT dose index (CTDI(vol)), dose-length product (DLP) and effective dose (ED) has been determined for each of the datasets, and compared to console prediction and scan summary values. Using phantom measurements of CTDI(vol), a method for separating comprehensive RD values of DE-acquisitions into the original RD contribution of each tube (80 kVp/140 kVp) has been developed, enabling comparison of all 3 datasets as if independently acquired using single-source "single-energy" technique. RESULTS: Highest IN was detected for 80 kVp- (38.6 ± 5.1HU), lowest for 120 kVp-equivalent linear blended M0.3-datasets (23.1 ± 3.4HU) with significant differences between all datasets (P<0.001). Highest SNR and CNR were measured for M0.3- (SNR: 14.8 ± 4.1; CNR: 11.6 ± 3.8) and 80 kVp-datasets (SNR: 13.8 ± 4.8; CNR: 11.2 ± 4.5); lowest for 140 kVp-datasets (SNR: 9.5 ± 2.5; CNR: 7.1 ± 2.3) with significant differences between M0.3- and 140 kVp-datasets as well as between 80 kVp- and 140 kVp-datasets (both P<0.001 for both CNR, SNR). CTDI(vol), DLP and ED were reduced by 50% for low-kilovoltage acquisitions (CTDI(vol): 5.5 ± 1.4 mGy; DLP: 127.8 ± 40.1 mGy cm; ED: 1.9 ± 0.6 mSv) compared to comprehensive DE-acquisitions (CTDI(vol): 11.0 ± 2.3 mGy; DLP: 253.8 ± 67.5 mGy cm; ED: 3.8 ± 1.0 mSv, tube contribution: 80 kVp: 44.5%; 140 kVp: 55.5%), and by 20% compared to conventional acquisitions at 120 kVp (CTDI(vol): 6.71 mGy; DLP: 153.5 ± 16.9 mGy cm; ED: 2.3 ± 0.3 mSv). CONCLUSIONS: Despite higher IN, low-kilovoltage CT-cholangiography reveals no significant difference with respect to CNR and SNR when compared to linear blended images yielded by DECT. Compared to DECT or conventional CT at 120 kVp, contrast-enhanced low-kVp CT cholangiography potentially allows reduction of patient dose by up to 50% or 20%, respectively. Therefore, CT-cholangiography at 80 kVp should be considered as an alternative to DECT-cholangiography whenever DECT is unavailable, or if increased image quality of DECT regarding quantitative bile duct evaluation is not needed for diagnosis. SN - 1872-7727 UR - https://www.unboundmedicine.com/medline/citation/21458939/Dual_energy_standard_and_low_kVp_contrast_enhanced_CT_cholangiography:_a_comparative_analysis_of_image_quality_and_radiation_exposure_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0720-048X(11)00300-7 DB - PRIME DP - Unbound Medicine ER -