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Doxycycline for malaria chemoprophylaxis and treatment: report from the CDC expert meeting on malaria chemoprophylaxis.
Am J Trop Med Hyg. 2011 Apr; 84(4):517-31.AJ

Abstract

Doxycycline, a synthetically derived tetracycline, is a partially efficacious causal prophylactic (liver stage of Plasmodium) drug and a slow acting blood schizontocidal agent highly effective for the prevention of malaria. When used in conjunction with a fast acting schizontocidal agent, it is also highly effective for malaria treatment. Doxycycline is especially useful as a prophylaxis in areas with chloroquine and multidrug-resistant Plasmodium falciparum malaria. Although not recommended for pregnant women and children < 8 years of age, severe adverse events are rarely reported for doxycycline. This report examines the evidence behind current recommendations for the use of doxycycline for malaria and summarizes the available literature on its safety and tolerability.

Authors+Show Affiliations

Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, 4770 Buford Hwy., Atlanta, GA 30341, USA. ktan@cdc.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Practice Guideline

Language

eng

PubMed ID

21460003

Citation

Tan, Kathrine R., et al. "Doxycycline for Malaria Chemoprophylaxis and Treatment: Report From the CDC Expert Meeting On Malaria Chemoprophylaxis." The American Journal of Tropical Medicine and Hygiene, vol. 84, no. 4, 2011, pp. 517-31.
Tan KR, Magill AJ, Parise ME, et al. Doxycycline for malaria chemoprophylaxis and treatment: report from the CDC expert meeting on malaria chemoprophylaxis. Am J Trop Med Hyg. 2011;84(4):517-31.
Tan, K. R., Magill, A. J., Parise, M. E., & Arguin, P. M. (2011). Doxycycline for malaria chemoprophylaxis and treatment: report from the CDC expert meeting on malaria chemoprophylaxis. The American Journal of Tropical Medicine and Hygiene, 84(4), 517-31. https://doi.org/10.4269/ajtmh.2011.10-0285
Tan KR, et al. Doxycycline for Malaria Chemoprophylaxis and Treatment: Report From the CDC Expert Meeting On Malaria Chemoprophylaxis. Am J Trop Med Hyg. 2011;84(4):517-31. PubMed PMID: 21460003.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Doxycycline for malaria chemoprophylaxis and treatment: report from the CDC expert meeting on malaria chemoprophylaxis. AU - Tan,Kathrine R, AU - Magill,Alan J, AU - Parise,Monica E, AU - Arguin,Paul M, AU - ,, PY - 2011/4/5/entrez PY - 2011/4/5/pubmed PY - 2011/6/8/medline SP - 517 EP - 31 JF - The American journal of tropical medicine and hygiene JO - Am. J. Trop. Med. Hyg. VL - 84 IS - 4 N2 - Doxycycline, a synthetically derived tetracycline, is a partially efficacious causal prophylactic (liver stage of Plasmodium) drug and a slow acting blood schizontocidal agent highly effective for the prevention of malaria. When used in conjunction with a fast acting schizontocidal agent, it is also highly effective for malaria treatment. Doxycycline is especially useful as a prophylaxis in areas with chloroquine and multidrug-resistant Plasmodium falciparum malaria. Although not recommended for pregnant women and children < 8 years of age, severe adverse events are rarely reported for doxycycline. This report examines the evidence behind current recommendations for the use of doxycycline for malaria and summarizes the available literature on its safety and tolerability. SN - 1476-1645 UR - https://www.unboundmedicine.com/medline/citation/21460003/full_citation L2 - http://www.ajtmh.org/content/journals/10.4269/ajtmh.2011.10-0285?crawler=true&amp;mimetype=application/pdf DB - PRIME DP - Unbound Medicine ER -